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Biomedical subjects

J Dumbach

Publications and source records attributed to J Dumbach.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Edema prevention with aprotinin in elective interventions in the area of the jaw and face (preliminary results)].

The effect of aprotinin on oedema prevention and pain following different maxillo-facial surgical interventions has been recorded in an open, non-comparative pilot study with 87 patients. After high dosage application of the proteinase inhibitor aprotinin only few cases exhibited a fully developed oedema and tension pain in the postoperative period. Postoperative wound-healing appeared also remarkably convenient. Incidence and severity of the postoperative swelling were altogether distinctly reduced in comparison to what would have been expected as the usual postoperative clinical condition of such patients.

Adolescent↗
PubMed1986

[Surgical therapy of regional lymph nodes in cancers of the lower lip].

Based on a retrospective follow-up study of patients with lower-lip carcinoma from 1968 to 1980, the incidence of metastases of such lesions was broken down according to tumor classification, and the survival rates for these patients were computed. In the total group of 89 patients with primary surgical treatment of the tumor and lymph nodes, 17 (19.1%) were found to have metastases. Among these tumors, 5 were classified as T1, 10 as T2, and 2 as T3. Analysis of the survival rate yielded the following results. To date, there has been no recurrence in any of the patients who underwent suprahyoid lymph-node removal with no histological evidence of lymph-node metastases. Of the 17 patients in whom histological lymph-node metastases were identified in the submandibular region following primary suprahyoid neck dissection, 64.7% showed no evidence of disease for 5 years on average, and all are still alive. In contrast, 90% of the patients died in whom the primary tumor was just treated locally and who did not undergo radical removal of the suprahyoid lymph-node until secondary metastases had occurred. In the light of our experience, suprahyoid lymph-node removal appears to be indicated as part of the primary treatment of lower-lip carcinoma, independent of the prevailing tumor stage. This may not apply to tumors that are clearly less than 1 cm in size.

Humans↗
PubMed1979

On the genetics of the human serum paraoxonase (EC 3.1.1.2).

Incubation of the sera of 799 nonrelated persons with paraoxon led to varying degrees of inhibition of the serum cholinesterase (EC 3.1.1.8) with residual activity between 0% and 67.4% of the initial activity. This is the result of a differing paraoxonase (EC 3.1.1.2) activity. The residual activities show a trimodal distribution. The results of studies of 99 families with children show that an autosomal dominant herdity factor is most likely. Consideration of the constellations of the activity values within the families can thus yield a stochastic external criterion. This, together with the shape of the distribution of the individual values, gives good statistical estimates for the distributions and frequencies of the three groups obtained by an iteration technique. Tests of association that take account of group membership show that residual activity does not depend on the blood groups A, B, O, and Rh, or on age. A conclusive argument for our assumption of three activity groups is that the resulting group frequencies are consistent with the Hardy-Weinberg rule.

ABO Blood-Group System↗