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J Dubousset

Publications and source records attributed to J Dubousset.

At least 37 records · Page 2Linked to original sources
PubMed2001

The AP diameter of the pelvis: a new criterion for continence in the exstrophy complex?

OBJECTIVE: Reconstructive surgery of bladder exstrophy remains a challenge. By using CT of the pelvis, we suggest a new pre- and post-operative investigative procedure to define the AP diameter (APD) as a predictive criterion for continence in this anomaly. PATIENTS AND METHODS: Three axial CT slices were selected in nine children with exstrophy who had undergone neonatal reconstructive surgery. The three levels selected were the first sacral plate, the mid acetabular plane and the superior pubic spine. We used combined slices to measure: APD = distance between the first sacral vertebra and the pubic symphysis. Pubic diastasis (PD). Three angles defined on the transverse plane of the first sacral vertebra--iliac wing angle, sacropubic angle and acetabular version. RESULTS: In exstrophy, the angles demonstrate opening of the iliac wings and the pubic ramus, and acetabular retroversion compared to controls. Comparisons between controls, continent and incontinent patients reveal that in continent patients, APD increases with growth and seems to be a predictive criterion for continence, independent of diastasis of the pubic symphysis. CONCLUSIONS: We believe that CT of the pelvis with measurements of the APD should be performed in all neonates with bladder exstrophy before reconstructive surgery and for better understanding of the malformation. The APD seems to be predictive and may be a major criterion for continence, independent of PD.

Bladder Exstrophy↗
PubMed2001

[Possible role of the pineal gland in the pathogenesis of idiopathic scoliosis. Experimental and clinical studies].

The unexpected finding in 1959 by Marie-Jeanne Thillard that pinealectomy in young chickens gives way to spinal deformities was confirmed by the authors. In another experiment they found that injected melatonine to the chick at adequate dose and at the same time as surgery, lessen or even totally prevents the occurrence of deformities. On the other hand, at too low dose or delayed after pinealectomy melatonine injection, may not prevent the deformity which will be persisting or even increasing. In a subsequent series of experiments on the rat, pinealectomy results in decreasing the plasmatic amount of melatonine as well as giving way to spinal deformities. The nature of these deformities observed here is dependent on the stature between of the animal. The normal quadrupede rat develops after pinealectomy a standard scoliosis. Inversely the scoliotic deformity occurs when the animal has been forced to a bipede condition, which may be achieved by removing its forelimbs when baby, then forcing it to stand and remain in erect posture by high enough feeding. Melatonine depressing and erect position are in two conditions, when associated, likely to give way to experimental scoliosis. In human, a low nycthemeral level of plasmatic melatonine is correlated with progressive scoliosis. The level of platelets calmoduline, when is normally modulated by melatonine, has been proved by Kindsfater to be increased in progressive scoliosis. Then raises the hypothesis that human idiopathic scoliosis may be due to an inherited disorder of neuro-transmitters from neuro-hormonal origin, associated with bipedal condition, where an horizontal localized neuro-muscular imbalance starts and produces the scoliotic deformity of the fibro-elastic and bony structures axial spinal pilar.

Animals↗
PubMed2000

Progressive rotational dislocation in kyphoscoliotic deformities: presentation and treatment.

STUDY DESIGN: Progressive rotational dislocation of the spine has been described as the most serious evolutive risk of kyphoscoliosis. A retrospective chart review was conducted on 11 patients with this deformity. OBJECTIVES: To delineate the clinical and radiologic characteristics of this entity to facilitate early diagnosis and treatment. The outcome after treatment was analyzed to point out the rationale for appropriate treatment. METHODS: The characteristic radiologic feature was a short sharp angled kyphosis (average 112) at the junction of two lordoscoliotic curvatures. The etiology of the spinal deformity was neurofibromatosis in four patients and various dysplastic conditions in seven patients. Two patients had congenital vertebral defects. Structural weakness of the bone was therefore a basic feature. Neurologic impairment was identified in three patients (one complete, two incomplete). Four patients had a nonunion after a previous attempt at spinal fusion: two after a combined anterior and posterior fusion with an anterior approach from the convexity and two after a posterior fusion alone. All patients underwent complete circumferential stabilization through anterior strut-grafting and posterior fusion. An anterior approach from the concavity was performed systematically with tibial strut grafts inserted in a palisade fashion. Preoperative correction of the deformity was performed by progressive controlled elongation in a Stagnara elongation cast. Cotrel-Dubousset instrumentation was used in two patients, Harrington instrumentation was used in two patients, and cast immobilization alone was used in seven patients. RESULTS: The average follow-up period was 5 years 5 months. All but one patient achieved successful spinal fusion. Loss of correction at the latest follow-up evaluation was less than 3 degrees in nine patients. The two patients with incomplete neurologic deficits were improved, but the patient with the complete deficit remained unchanged after surgery. CONCLUSIONS: Awareness of the possibility of a progressive rotational dislocation in dystrophic forms of kyphoscoliosis should allow for an early diagnosis and stabilization. The percentage of patients having a neurologic deficit in this series was significantly less important than in the initial report. Early anterior strut grafting from the concavity of the scoliotic curvature and posterior fusion is recommended.

Adolescent↗
PubMed2000

[Segmental instrumentation in idiopathic scoliosis. Role of the upright frontal plate for determination of the area of fusion].

PURPOSE OF THE STUDY: To analyze post operative imbalance after C.D.I. (Cotrel Dubousset Instrumentation) for idiopathic scoliosis according to the fused area, particularly the lower level of fusion. To recall a classification for determination of fusion area based on preoperative standing coronal radiograph. PATIENTS AND METHODS: To be included in this study the patients had to have an adolescent idiopathic scoliosis, at least two years of post operative follow up. 122 patients met the criteria; mean follow up was 3 years, 5 months (minimum 2 years, maximum 9 years). Scoliotic curves were classified as single structural (81), double structural (41). Balance was clinically analyzed by plumbline, radiographically by a plumbline dropped from C7 to the sacrum and measuring deviation from the midpoint of the sacrum in centimeters. A curve with a deviation of 10 mms or less was considered as balanced. RESULTS: Imbalance in single structural curves was 70% when using stable vertebra (King) or "other vertebra" (beyond stable vertebra or one or two levels upper stable vertebra). Using end vertebra (J. Moe), (elected vertebra - C. Salanova) imbalance was 10%. In double structural (41 cas) imbalance was 50% using stable, or "other vertebra" 10% when elected vertebra was fused. DISCUSSION: In this study there was a strong relationship between the lower level of fusion and imbalance.

Adolescent↗
PubMed2000

[Conservative surgical treatment of osteogenic sarcoma of the limb in children and adolescents].

PURPOSE OF THE STUDY: Advances in chemotherapy protocols over the last 20 years have considerably improved the prognosis and functional outcome in patients with osteogenic sarcoma. We report here the results of a cooperative study conducted under the auspices of the French Society of Pediatric Oncology (SFOP). Twenty-nine oncology centers participated in this retrospective national multicentric study. MATERIALS AND METHODS: The study included 153 patients with osteogenic sarcoma of the limb who were treated by the OS87 protocol with conservative surgery between 1987 and 1994. The OS87 protocol consisted in conservative or non-conservative surgery combined with pre- and postoperative chemotherapy. The following inclusion criteria were used: age under 20 years, tumor localization in a limb (pelvis and spine excluded), no metastasis at diagnosis, biopsy proven osteogenic sarcoma. RESULTS: Mean age at diagnosis was 13 years. The knee localization predominated (80 p. 100). 82.5 p. 100 of the patients had grade IIB disease (Enneking classification). For the 187 patients included in the protocol surgery was non-conservative in 20 p. 100 of the cases and conservative in 80 p. 100. The choice of the surgical technique (arthroplasty, allograft, autograft, resection without reconstruction) depended on the patient's age and school situation. Data analyzed here concerned only those patients who had conservative treatment. Mean follow-up was 64 months. The actuarial survival curve plateaued at 71 p. 100 at more than 6 years. Early and late complications were numerous and variable (mechanical, infectious, local recurrence). Secondary amputation was required in 10 p. 100 of the patients. The overall functional outcome of the preserved limbs was nevertheless good with rapid restoration of self-sufficiency despite major surgery and a high number of reoperations (about 65 p. 100 of cases). DISCUSSION: In light of the frequency and the seriousness of the complications, these results are modest. Patients and family should be advised of the risk, particularly the risk of secondary amputation which may be required early due to contaminated excision or at mid term due to major non-cancerological complications. As survival has been improved, functional capacity must be preserved for several years. This orients surgery towards more "biological" reconstruction which can provide greater longevity than arthroplasty.

Adolescent↗
PubMed2000

[Vascularized peroneal reconstruction after bloc resection of tumors or congenital malformations of the upper limb in children].

Limb salvage surgery is the standard care for most malignant tumor affecting the extremities in the child, and a vascularized fibula transfer is probably the most popular microsurgical option to reconstruct long-bone defects. Between 1994 and 1999, nine children with intractable diseases of the upper limb were treated using free vascularized fibula grafts (one patient had resection in 1983 and initially prosthetic reconstruction, then fibula transplant in 1996). There were 6 boys and 3 girls. Mean age was 10 years (between 6 and 16). Eight patients had defects after sarcoma resection, one had an aggressive enchondroma. The reconstructed sites were the humerus (= 6), the radius (n = 3). The length of the bone defect ranged from 8 to 19 cm (mean: 14.4 cm). The fibula head with the cartilage and the growth plate was used in 3 children. One girl, 4.5 years old with congenital pseudoarthrosis of radius and cubitus had a resection and reconstruction with a U shaped fibula transplant. One patient died from lung and brain metastasis, two years after the reconstruction. There were no local recurrences. The complications were numerous but usually benign; fracture of the grafted fibula n = 7, necessity of additional bone grafts (n = 4) malunion (n = 1) needed reoperation, pseudoarthrosis (n = 2) with reoperation, ankle valgus (n = 1) required reoperation, necrosis of the fibula head (n = 1), radial inclination (n = 1). The ten patients had bone union. The mean period required to obtain radiographic bone union was 5 months. The functional results of the remaining patients were evaluated according to the scale of ENNEKING. The results ranged from 21 to 30 points. Our results were satisfactory with regard to pain, emotional acceptance, manual dexterity. The vascularized fibula graft is indicated in children with large bone defects, more than 8 cm in the humerus, radius and ulna.

Adolescent↗
PubMed1999

Pathogenesis of idiopathic scoliosis. Experimental study in rats.

STUDY DESIGN: A radiographic examination of pinealectomized rats to observe the development of scoliosis and halt the condition by administration of melatonin. OBJECTIVES: To discover whether pinealectomy has the same effect in mammals as shown in the chicken, and to determine whether the bipedal condition is important for development of scoliosis. SUMMARY OF BACKGROUND DATA: Pinealectomizing chickens shortly after hatching consistently resulted in scoliosis closely resembling human idiopathic scoliosis. It has not been determined whether this phenomenon is restricted solely to chickens, or if this experimental model is applicable to other animals, especially those more closely related to humans. METHODS: A sham operation in five bipedal rats served as the control in this study. Pinealectomy was performed in 10 quadrupedal rats, pinealectomy in 20 bipedal rats, and pinealectomy with implantation of melatonin pellet in 10 bipedal rats. Spinal radiographs were used to measure the degree of scoliosis at 3 months after surgery. RESULTS: Scoliosis developed only in pinealectomized bipedal rats and not in quadrupedal rats. It developed in none of the sham operation group and in only 1 of 10 pinealectomized bipedal rats with melatonin treatment. CONCLUSIONS: Melatonin deficiency secondary to pinealectomy alone does not produce scoliosis if the quadrupedal condition is maintained. The bipedal condition, such as that in chickens or humans, plays an important role in the development of scoliosis. The findings suggest a critical influence of a postural mechanism for the development of scoliosis.

Animals↗
PubMed1999

Establishment, characterisation and partial cytokine expression profile of a new human osteosarcoma cell line (CAL 72).

Permanent human osteosarcoma cell lines are important tools for the study of bone cancer. As representative of an osteoblastic phenotype, they partly reflect their normal osteoblastic counterparts and, thus, may represent appropriate models to investigate the mechanisms involved in bone remodelling and in haematopoietic differentiation. In the present work, we describe a new human cell line, CAL 72, obtained from an osteosarcoma of the knee of a 10-year-old boy. These cells grow in continuous culture, and karyotypic analysis has revealed clonal abnormalities in number and structure, especially loss of chromosome Y. These cells exhibit morphological, immuno-histochemical and molecular characteristics of the osteoblastic lineage. Using RT-PCR, we have shown that the CAL 72 cell line expresses high levels of mRNA coding for several cytokines, such as G-CSF, GM-CSF, IL-1beta and IL-6. In view of this expression profile, the CAL 72 phenotype appears to be closer to normal primary osteoblasts than other reported osteosarcomas. Moreover, these cells express mRNA for both HGF and its receptor c-MET, suggesting that this autocrine loop might contribute to the invasiveness of the tumour from which CAL 72 originated.

Alkaline Phosphatase↗
PubMed1999

Ischio-vertebral dysplasia: a distinct entity.

BACKGROUND: Kyphoscoliosis is a complication of some bone dysplasias, including cleidocranial dysplasia. OBJECTIVES: We report a distinct disorder with defective ossification of the ischial rami, severe kyphoscoliosis and normal clavicles. Early recognition of this syndrome allows prevention of complications. MATERIALS AND METHODS: All patient cases (aged 1 day to 33 years) were selected according to the above criteria, with special attention to radiological findings, family history and follow-up (5-30 years). RESULTS: In all eight patients, we observed the following: (a) Severe thoracic scoliosis of early onset and rapid progression, leading to rotatory dislocation. Spinal cord compression occurred in four cases with respiratory problems related to chest deformity. (b) Bilateral and symmetrical incomplete ossification of the ischial rami. (c) Peculiar facies with retrognathia. (d) Normal clavicles. Three patients were from the same family (grandmother, mother and daughter). CONCLUSION: Ischio-vertebral dysplasia seems to represent a true entity, with radiological and genetic findings that make it distinct from cleidocranial dysostosis. The association of kyphoscoliosis and these pelvic abnormalities is specific for this condition. Neurological and respiratory complications can be avoided if the condition is recognised early and early treatment is instituted.

Abnormalities, Multiple↗
PubMed1999

Prognosis of children with malignant pheochromocytoma. Report of 2 cases and review of the literature.

Malignant pheochromocytomas are rare in childhood and the prognosis of children with this tumor is not well known. We present 2 pediatric observations of malignant pelvic pheochromocytoma. Symptoms in both cases were headache and hypertension. The tumor invaded the sacral bone. Angiogram helped to localize the tumor and metastases, and allowed preoperative embolization of the tumor in 1 case. The first child underwent incomplete surgical resection, (131)I-MIBG therapy and radiotherapy, and is still alive 2 years after diagnosis. The second child died from metastatic invasion a few weeks after discovery of the tumor. We reviewed previous reports of children with malignant pheochromocytomas (30 cases). Primary tumor was extraadrenal in 50% of cases. The 3-year survival rate was 73 +/- 9% (mean +/- SD). Apart from surgical resection, no particular treatment appeared to be more effective than others in reducing mortality.

3-Iodobenzylguanidine↗
PubMed1999

[Idiopathic scoliosis. Definition--pathology--classification--etiology].

Scoliosis is a symptom, it is not a disease. Mechanically, scoliosis is a torsion of the basic elements of the spine developed according to an helicoidal axis. Scoliosis is called idiopathic when no inductive disorder like paralysis, congenital malformation, or metabolic disease, have been established. Idiopathic scoliosis arises during infancy or childhood and gives spontaneously as big deformity as earlier started. The thoracic location gives not only a rib hump, but also respiratory impairment when a severe deformity is obtained. Lumbar location gives mainly imbalance and pain. Etiology is still unknown, but recent research lead to a neuromuscular disorder in relation with the neuro-transmitter involved with the bipedal condition with very often a genetic input. With time degenerative lesions of the discal and ligaments components increase the deformity established during childhood and adolescence, but also these degenerative disorders can create scoliosis deformity only in adulthood arising on normally aligned spines.

Child↗
PubMed1998

Evaluation of a new low-dose digital x-ray device: first dosimetric and clinical results in children.

BACKGROUND: A new low-dose digital X-ray device, based on Charpak's Nobel prize-winning multiwire chamber, enables the production of images at very low doses. Objectives. To present the first dosimetric and clinical results. MATERIALS AND METHODS: The analysis was performed on 93 children with scoliosis and 47 undergoing pelvic radiography. The comparative study between conventional X-ray and the new technique focused on three points: (1) the dose delivered by each system (2) the diagnostic information provided by each system and (3) comparison of image quality criteria with European guidelines. RESULTS: The mean ratio of conventional dose to that of the low-dose technique was 13.1 for the spinal examination and 18.8 for the pelvis. There was no significant difference in diagnostic information available from each modality, but there was a slight difference in quality criteria in favour of the conventional technique. CONCLUSION: This new device allows spectacular dose reduction, consistent with adequate clinical information. Improvements of the prototype will lead to extension of potential indications and industrial development.

Child↗
PubMed1997

Role of serotonin for scoliotic deformity in pinealectomized chicken.

STUDY DESIGN: The effect of intraperitoneal injection of 5-hydroxytryptophan (5-HTP) versus control in pinealectomized chickens. OBJECTIVE: To find if the serotonin may have some role in the cause of treatment of idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: One of the causes of idiopathic scoliosis is thought to be the disruption of postural reflex. Serotonin has been proposed to have a crucial role in maintaining normal postural muscle tone or postural equilibrium. METHOD: Forty pinealectomized chickens served as controls, and an additional 40 pinealectomized chickens received daily intraperitoneal injections of 5-hydroxy-tryptophan, a precursor of serotonin, which can pass through the blood-brain barrier. Spine radiographs were examined to measure the scoliotic deformity. RESULTS: Scoliosis developed in all 40 pinealectomized chickens (control), whereas only 28 chickens in the 5-hydroxytryptophan-treated group (6 in severe, 22 in mild) had scoliosis developed. The remaining 12 chickens grew up with normal spines. Most chickens with mild scoliosis did not have curve progression but continued to have wedged vertebrae. CONCLUSION: Serotonin deficit secondary to a defect of melatonin may have disturbed postural muscle tone or postural equilibrium resulting in scoliosis in pinealectomized chicken. Prevention from the development of scoliosis or its progression in chickens treated with 5-hydroxytryptophan suggests that serotonin may have potential therapeutic value.

5-Hydroxytryptophan↗
PubMed1997

Operative treatment of scoliosis with Cotrel-Dubousset-Hopf instrumentation. New anterior spinal device.

STUDY DESIGN: This study analyzes the effects of a new anterior spinal instrumentation system and the results of use in 50 patients with scoliosis. OBJECTIVES: Anterior spine systems are reviewed. The principles of a new anterior spinal instrumentation system allowing for postoperative care without external support are discussed. SUMMARY OF BACKGROUND DATA: Numerous different implants have been presented in the literature for anterior spinal surgery. Nevertheless a primary stable anterior instrumentation was not available for multisegmental procedures until now, and the restoration of lordosis in the lumbar spine was very difficult with the common devices. The development of more stable devices that also allow a restoration of lordosis in combination with derotation and compression is discussed. METHODS: Fifty patients with scoliosis of different etiologies (neuromuscular: n = 33; idiopathic: n = 16; congenital: n = 1) underwent anterior spinal surgery at the thoracic, thoracolumbar, and lumbar spine. During follow-up, no revision operation was necessary after the monosegmental and multisegmental application of this method, and there were no vessel complications. The results were controlled with a mean follow-up of 26.6 (range 12-41) months. RESULTS: Clinical and radiologic follow-up and complications are reported. Statistical data obtained show a different average blood loss and operation time depending on the different etiology of the scoliotic deformity. The mean corrections for the scolioses by etiology are as follows: myelomeningocele (MMC) (mean preoperative angle 89 degrees, mean correction 54%); neuromuscular (81 degrees, 46%); and idiopathic (55 degrees, 69%). The mean lordosis of the lumbar spine was 29.2 degrees (measured between T12-S1) and could be corrected to 45.2 degrees depending on the etiology of the curvature, whereas the angle of the thoracic kyphosis did not show an essential change. The segmental measurement in idiopathic scoliosis did not show a kyphosization in the lumbar spine. Derotation of the apical vertebra in 15 patients in relation to the sagittal plane was 37%. CONCLUSIONS: The study shows the effect of a new anterior device allowing the application of three-dimensional correction forces to the spine. Particularly in scoliosis derotation, compression and restoration of lordosis are possible. Primary stability is obtained by anchoring the implants with a new wedge-locking technique, which makes postoperative external support unnecessary.

Adolescent↗
PubMed1997

Treatment of spondylolysis and spondylolisthesis in children and adolescents.

The treatment of spondylolysis and spondylolisthesis in children depends on the severity of clinical symptoms, pathologic anatomy, and prognosis. Simple spondylolysis can be cured by immobilization alone in selected cases, or by surgery when it remains symptomatic and resistant to nonoperative treatment. The majority of cases are asymptomatic and require no treatment. Spondylolisthesis is classified into 2 types based on the magnitude of the lumbosacral angle: spondylolisthesis with a horizontal sacrum (lumbosacral angle > or = 100 degrees), which seldom requires surgical treatment, usually responds to orthotic management, and generally shows little progression; spondylolisthesis with a vertical sacrum (lumbosacral angle < 100 degrees) which is always progressive, can produce neurologic impairment and cosmetic and functional disability, and requires surgical treatment. In 17 cases the author has reduced the latter deformity by gradual traction in hyperextension followed by cast immobilization, then stabilized the reduction by posterolateral fusion performed through the cast without instrumentation and without opening the spinal canal. When the lumbosacral angle is not improved to 100 degrees or more by hyperextension and traction, an anterior console interbody fusion is added before the posterolateral fusion.

Adolescent↗
PubMed1997

[A protocol of in vivo 3D experimental evaluation of global posture and motion of the spine].

PURPOSE: The aim of his study was to assess 3D global posture and movement of body segments, especially for scoliotic subjects. As scoliosis is a three-dimensional deformity, it needs three-dimensional evaluation and correction, but there is no mean today to get 3D dynamic examination of the whole body. MATERIAL AND METHODS: Using opto-electronic methods, an experimental protocol was established to compare the pre- and post-operative results of treatment. Firstly, the reliability of the protocol was tested in healthy adult subject. Secondly, a reference group of 15 healthy teenagers was analysed Besides, first scoliotic subject in pre- and post-operative situations were followed. The markers fixed on the skin allowed us to calculate the position of the head, the pelvic, the shoulders and the spinal axis, during a static trial and motions. RESULTS: The reliability of the protocol was satisfactory (standard deviation (s) < 5.4 degrees in a flexion movement). The inter-subject variability was greater for the position of the head than for the pelvis, the shoulders or the spinal axis. The scoliotic patient showed a straightening of the whole body in the three anatomic planes. One month after treatment, the range of motion were reduced (+13.8 degrees for the pelvic flexion during a flexion movement), but six months after surgery they were greater than before (+14.7 degrees). CONCLUSION-DISCUSSION: Many systems have been proposed to measure the motion of the trunk, but they were not three-dimensional. The opto-electronic method is a non invasive, external and dynamic system.

Adult↗
PubMed1997

[Free fibula transplant and practical approach in the absence of posterior tibial artery. A report of 2 cases].

The authors report two well documented cases of absent posterior tibial artery in patients undergoing free fibula transplant. The first patient was a 50-year-old woman treated by pelvimandibulectomy for squamous cell carcinoma, leaving a defect of the floor of the mouth. The second case was an 11-year-old child with Ewing sarcoma of the femoral metaphysis, in whom femoral reconstruction was performed by vascularized free fibula transplant. Based on these two cases, the authors describe their diagnostic and therapeutic approach designed to avoid risks associated with this anatomical variant. Absence of the posterior tibial artery can be confirmed by arteriography and duplex ultrasound. The authors propose duplex ultrasound as first-line investigation as this safe, noninvasive examination provides sufficient information in the majority of cases at a lower cost. In parallel, the various anatomical variants affecting the origin of leg arteries from the popliteal artery are classified into seven groups based on a phylogenetic and embryological study.

Bone Neoplasms↗