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Biomedical subjects

J Dry

Publications and source records attributed to J Dry.

At least 145 records · Page 8Linked to original sources
PubMed1980

[Obesity and the nociceptive reflex (author's transl)].

Using electrophysiological methods for studying pain in human, the authors have studied comparatively the sensation of pain and the threshold of a nociceptive flexion reflex of the lower limb, both elicited by electrical stimulation of sural nerve in 20 obese women (weight greater than or equal to 30 p. 100 of ideal weight) and 14 normal weighing women as controls. In obeses, the threshold of the nociceptive flexion reflex is very significantly lower (5,4 +/- 2 mA in obesity, 9,7 +/- 1,6 mA in controls p < 0,0001). The authors suggests an hypothesis of insufficiency of endogenous opiate releasing in human obesity.

Adolescent↗
PubMed1980

[Histamine and serotonin levels in exercise induced bronchospasm in asthmatics (author's transl)].

The authors studied variations in histamine and serotonin levels in whole blood, in ten asthmatics with bronchospasm induced by running. A significant elevation of histamine following exercise was noted both in the asthmatics and in the control group and the difference in histamine levels in the two groups is then significant. However no correlation was found between the level of histamine before or after exercise and bronchospasm or the intensity of the drop in FEV1. This is also true of serotonine. The changes in level of these amines thus seem top play a minimal role in the initiation and intensity of exercise induced bronchospasm in asthmatics.

Adolescent↗
PubMed1980

Human basophil degranulation in dermatophagoides allergies: 93 cases.

In tests conducted on 93 subjects human basophil degranulation (HBD) with Dermatophagoides pteronyssinus (DP) and Dermatophagoïdes farinae (DF), often involved in house dust allergy, were studied. The human basophil degranulation technique involves the enrichment of the circulating basophils of the patient allowing readings in the microscope on a fixed and colored slide and a count of at least 100 basophils, the minimum number necessary to give an adequate interpretation of the results. For each allergen dilution ratios of 100 microgram/ml, 10 microgram/ml and I microgram/ml were used. The degranulation was significant (p less than 0.001) for values higher than 35% (HBD positive). Out of 30 subjects with a positive skin test with DP, 27 had a positive HBD; no HBD was obtained in subjects with negative skin test (95% of concordance). With DF, out of 30 subjects the concordance reached the level of 86.6%. Contrary to previous work conducted on grass pollen extracts, no significant correlation was found between the skin test diameter and HBD. This might be due to the variable allergenic potency of the dermatophagoïdes extracts used for the skin tests. The HBD has now been confirmed as a simple and reliable technique for studying reaginic allergies.

Allergens↗
PubMed1979

Study of urinary excretion of butobarbitone in man in relation to the percentage of ideal body weight.

1 Thirty-three patients with no evidence of endocrine disease, hepatic or renal insufficiency or sleep disorders, were classified in groups 1 to 4 in order of increasing of percentage of ideal body weight (IBW) respectively: less than 90% of IBW, 90--120%, 120--180%, and greater than 180% of IBW. After oral administration of 200 mg butobarbitone, concentration of the intact drug was measured by gas liquid chromatographic assay in urine samples collected during 72 h and at three times in blood. 2 A highly significant negative relationship was found between the cumulative excretion of butobarbitone with urine and the logarithm of the percentage of IBW. In contrast for a given weight, excretion of the drug with urine was found to be weakly correlated with the diuresis. 3 The cumulative urinary elimination of butobarbitone was significantly different between the groups studied, except of the difference between the group 2 and 3 of the patients. No significant difference was found between the renal clearances of butobarbitone in the four groups of subjects. 4 We conclude that redistribution of butobarbitone into adipose tissues can explain the obtained results and that obesity modifies the pharmacokinetics of the drug.

Adult↗
PubMed1979

[Acute toxoplasmosis with necrotizing vasculitis (author's transl)].

Acute toxoplasmosis was diagnosed in a Japanese woman aged 31 years after the discovery of a raised lysis titre and agglutinins resistant to 2-ME, as well as early increases in specific IgM followed later by increases in specific IgG. A high fever was present and signs of mainly distal polymyositis. The muscle lesion was confirmed by EMG examination. No increase in muscle enzyme levels was noted at any stage of the disease. Muscle biopsy demonstrated inflammatory lesions in interstitial tissue and perimysium, and, more particularly, segmental necrotizing arteritis in several arterioles. All the arteriolar lesions were at the same stage of development. After prednisolone (60 mg/day) had failed to produce improvement, spiramycin was given and caused apyrexia in 48 hours and definite disappearance of all muscle signs within several days. Recovery was complete and there was no return of symptoms 18 months later. The authors discuss the association of acute toxoplasmosis, polymyositis, and necrotizing vasculitis, and suggest a possible pathogenic role for the immune complexes deposited on the arterial walls.

Acute Disease↗
PubMed1979

[Prolactin adenoma and Wermer's syndrome. A 10-year follow-up of a case with two parathyroid tumors, as adrenal adenoma, and a malignant pancreatic tumor (author's transl)].

A man of 38 years of age was found to have a type I endocrine polyadenomatosis in 1969. He was operated upon for removal of tumor of the islets of Langerhans with lymph gland metastases, and the head of the pancreas was removed. This was followed at a later date by ablation of two parathyroid adenomas. A clinically silent adenoma of the left adrenal was not removed and a silent and enclosed pituitary tumore was discovered. There were no clinical or hormonal signs of progression of the pancreatic tumor ten years later, but hypertension and behavioural disorders had developed. Catecholamine levels were normal. Selective blood aldosterone levels were just within significant values. A massive increase in prolactin secretion (more than 100 times the normal) was noted. This could be reduced by bromocriptine, and the possible role of prolactin in the behavioural disorders present is discussed.

Adenoma↗
PubMed1978

[Eosinophilia and respiratory function in the asthmatic subject (author's transl)].

Total eosinophil count (TEC) was done in 13 normal subjects, in 8 subjects before and 90 mn after a "French" breakfast and in 29 asthmatic patients. The geometric mean is higher (p less than 0,001) in asthmatic than in normal subjects : 304 (231-391) versus 144 (101-197). The breakfast does not interfer with the result of the TEC. In asthmatic subjects, a significant inverse correlation appears (r = 0,57, p less than 0,01) between the logarithm of TEC forced expiratory volume in one second and the quotient : vital capacity. This correlation persists whatever may be the subject's age, the duration of the asthma or age at which he first contracted the illness. Asthma appeared after 40 years in 4 of the subjects : their TEC was higher (p less than 0,01) than in subjects who had become asthmatic before the age of forty. The respiratory function was lowered more in these 4 patients than in others who had been ill for the same time (p less than 0,001). The TEC is not related to results of skin testing with usual inhalant allergens (grass pollen, house dust, cat's or dog's dander) or by result of a provocation test (by inhalation of allergen). Eosinophilia and bronchial obstruction are connected by one (or more) factors that may be inhalant allergens in extrinsec asthma and circulating immune complexes in intrinsec asthma.

Adult↗