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Biomedical subjects

J Dry

Publications and source records attributed to J Dry.

At least 271 records · Page 15Linked to original sources
PubMedDate not supplied

[Hormonal stimulation after injection of thyrotrophin releasing factor (TRF) and 1-24 ACTH in patients following chronic treatment with neuroleptics (author's transl)].

Fifteen patients with neuroleptic treatment (haloperidol 4 to 6 mg a day or phenothiazines) and eleven control patients were given TRH 250 microgram i.v. and 1-24 ACTH, i.m. different times, TSH, T3, T4, FT4, Prolactin (PRL) cortisol were measured. Before TRH injection, at baseline, TSH is higher (p less than 0,01) and T3 lower (p less than 0,05) in the neuroleptics treated group than in the control group. These results suggest the occurrence of a biological hypothyroidism in the group with neuroleptics; moreover PRL is significantly increased. After TRH injection the response is not significantly different between the two groups. Cortisol level is lower at baseline and after 1-24 ACTH injections in the group with neuroleptics.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Human basophil degranulation test in the diagnosis of anguilluliasis. Preliminary results].

The human basophil degranulation test was applied to the diagnosis of strongyloidiasis. The preliminary results show an excellent response. 33 of the 35 cases give a definite positive result and in the 15 control cases, with no parasitosis or an other helminthiasis, the test was negative. If these results are confirmed by a more important study of sensitivity and specificity, the test would be of interest when the parasitosis is of difficult evidence and especially by patients needing immunodepressive therapy.

Animals↗
PubMedDate not supplied

[2 new cases of Refsum's disease. Course during diet].

The authors report two cases of Refsum's disease treated with a low phytanic acid and low phytol diet for more than 5 years. The clinical, neurological improvement was undoubted in both cases but it was very gradual, appearing after 10 1/2 and 6 months treatment respectively. During these 5 years, no neurological aggravation occurred in the first patient ; but her sister presented in september 1972, 18 months after she started the diet, a mild attack from which she recovered. On the other hand, the sight and hearing disorders remained unchanged in spite of the considerable fall in phytanemia. In spite of the demanding and unagreeable character of the diet, almost constant moderate diarrhoea, the diet was worth following.

Adult↗
PubMedDate not supplied

[Refsum's disease].

Refsum's disease although rare is of great interest for it may benefit at least partially from treatment. Its clinical diagnosis depends on the association of pigmented retinitis, polyneuritis and cerebellar syndrome. It is confirmed beyond doubt by the increased C.S.F. protein and phytanemia. A full family history is necessary for it is possible to detect heterozygous carriers of the defect by enzyme studies on fibroblast cultures.

Adolescent↗
PubMedDate not supplied

[Evaluation of the results of treatment of Graves' disease by synthetic antithyroid drugs].

A study of 43 case records of Grave's disease followed up for at least two years after stopping treatment with synthetic antithyroid drugs, revealed 7 patients who did not relapse, 12 cases of rebound, (less than six months after stopping treatment), and 21 cases of recurrence (more than six months) of 10 cases (23%) had several recurrences. In relation to the 87 patients who formed this series, the cure rate after a single acute attack was only 50%. The good tolerance of antithyroid drugs, their almost complete efficacy, (2 failures out of 87 patients), indicate however that for a first attack they should be given for at least 18 months. Rebounds and recurrences suggest that radical treatment, mainly surgery, still have their place.

Adolescent↗