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Biomedical subjects

J Doroszewski

Publications and source records attributed to J Doroszewski.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Solving pathophysiological problems.

The aim of this paper was to analyze particular aspects of problem solving in pathophysiology. It is related to various kinds of knowledge presentation (textbook-type descriptions and computer programs) that are important for reasoning.

Artificial Intelligence↗
PubMedDate not supplied

Simple logical structures of medical reasoning and action.

The aim of this study is to delineate the fields of research on medical problem solving and action in which the use of logical methods may be fruitful and to describe the topics related to these fields in a way which would make easier further formal analysis. Four types of reasoning, namely, direct inference, verification of hypotheses, proving and explanation, are distinguished; simple examples of their application in the diagnostic and therapeutic inference-making are presented, and a complex, systemic character of reasoning in actual situations is described. The remarks concerning logical questions connected with the time factor, uncertainty and health values indicate the main sources of difficult problems which appear in a formal analysis. Medical action is represented as a sequence of consecutive, parallel and ramified diagnostic and therapeutic stages; the role of the plan of action and the importance of the cooperation between the doctor and the patient are stressed.

Logic↗
PubMedDate not supplied

Locomotion of granulocytes on an inclined plane.

The paper presents a quantitative study of the trajectories of rat granulocytes (PMNs) migrating on a glass surface inclined at various angles, i.e. under the action of gravitational force component parallel to the plane. The action of the force of the order of 5 X 10(-13) N (component parallel to the plane inclined at 80 degrees) accompanied by the decrease of a gravitational component perpendicular to the surface does not disrupt the adhesion contact of migrating PMNs with the serum coated glass surface. Under the action of the external force parallel to the surface, the PMNs exhibit a tendency to migrate in the direction of the force vector and the angles between elementary segments (steps) of cell trajectories are smaller in comparison with migration on a horizontal plane (0 degrees inclination). It has been found that the mean velocity of motion of PMNs locomoting on a steep slope (70 degrees and 80 degrees) is greater in comparison with the migration velocity on a horizontal surface. The increase of velocity concerns not only cells migrating in the downward direction, but also those which move upwards. Possible mechanisms of the influence of external force on direction and rate of migration of granulocytes are discussed, namely modification of adhesion force, stimulation of cell motile activity, individual variability of cell adhesive and migration properties, shortening of transient locomotory adhesions.

Animals↗