Search PubMed⌕ Search

Biomedical subjects

J Dor

Publications and source records attributed to J Dor.

At least 127 records · Page 7Linked to original sources
PubMed1982

Elective cervical suture of twin pregnancies diagnosed ultrasonically in the first trimester following induced ovulation.

The efficiency of elective cervical suture in preventing premature delivery thus reducing neonatal mortality was studied in a group of 50 twin pregnancies. All pregnancies occurred after induction of ovulation and twins were diagnosed early by ultrasound. 25 randomly selected patients underwent elective cervical suture. 22 sutured and 23 non-sutured patients were followed until delivery, while 5 patients aborted in the second trimester. The benefit of suturing on the duration of pregnancy and its outcome were assessed. Of the sutured patients, 10 (45.4%) delivered prematurely and the neonatal death rate was 18.2%. In the non-sutured patients, 11 (47.8%) delivered prematurely and the neonatal death rate was 15.2%. This study demonstrates that elective cervical suture was not effective in prolonging gestation or improving fetal outcome in twin pregnancies following induced ovulation.

Adult↗
PubMed1981

The influence of anti-zona and anti-sperm antibodies on sperm--egg interactions.

Anti-zona antibodies are effective inhibitors of fertilization in vitro and, regardless of whether passive or active immunization techniques are used, in vivo. Antibodies raised against unfractionated zona pellucida antigens are chiefly directed against a group of carbohydrate-rich components localized on the outer surface of the zona. The interaction of anti-zona antibodies with these sites induces the formation of a surface precipitate which occludes the sperm binding sites by a process of steric hindrance, and stabilizes the zona structure against digestion by the proteolytic enzymes of the sperm head. Active immunization studies indicate that the long-term induction of infertility without adverse side effects is feasible in both laboratory rodents and primates when the zona pellucida is used as a target. Anti-sperm antibodies also exhibit a capacity for inhibiting fertilization in vivo and in vitro. To determine the most appropriate detection method to screen patients for anti-sperm antibodies several homologous and heterologous antisera were analysed by 5 different agglutination and immobilization techniques and then compared for their ability to inhibit the fertilizing capacity of human spermatozoa using the zona-free hamster egg penetration test. The results obtained with the Franklin--Dukes tube--slide test exhibited the closest correlation with the anti-fertility activity of a given antiserum; this activity could be amplified by the addition of complement to the medium. It is concluded that antibodies directed against the sperm head are responsible for limiting the fertilizing capacity of human spermatozoa in vitro and that it is these antibodies of which attention should be focused to unravel the role that immunological factors play in the aetiology of infertility in vivo.

Animals↗
PubMed1981

Antisperm antibodies: their effect on the process of fertilization studied in vitro.

The influence of antisperm antibodies on the fertilizing capacity of human sperm was investigated in a zone-free hamster egg system using heterologous and homologous antisera. The ability of these antisera to interfere with the fertilizing capacity of human spermatozoa correlated well with the antibody titers obtained using the Franklin-Dukes tube slide test. However, there was little correlation between the antifertility effects of these antisera and their activities in the gelatin and tray agglutination tests. The addition of complement to the incubation medium amplified the inhibitory activity exhibited by these antisera, although the extent of this inhibitory influence bore no relationship to the antibody titers obtained using the complement-dependent sperm-immobilization technique. The study demonstrates the importance of the hamster egg penetration test in evaluating the antifertility effect of antisperm antibodies.

Animals↗
PubMed1981

Triplet pregnancy in uterus didelphys with delivery interval of 72 days.

A unique case of triplet pregnancy in a woman with uterus didelphys is described, with fetuses A and B in the right uterine horn and fetus C in the left horn. Missed abortion of fetus A was diagnosed in the 22nd week of gestation by real-time ultrasonography, but only in the 27th week of gestation did the right uterine horn contract, resulting in expulsion of fetus A. Fetus B was delivered by cesarean section 2 hours later. Fetus C remained in the left uterine horn until the 37th week of gestation, when a viable 2490-g female infant was delivered by cesarean section. Triplet pregnancy occurs with sufficient frequency to be unremarkable; however, triplet pregnancy in a patient with uterus didelphys and with 72 days' lapse between the delivery of the first 2 fetuses and delivery of the third is a rare occurrence.

Abortion, Missed↗
PubMed1980

Cumulative conception rates following gonadotropin therapy.

During the years 1963 to 1978, 515 patients were treated with HMG. They were divided into two groups depending upon the absence (Group I) or presence (Group II) of distinct endogenous estrogen activity. Group II patients were referred after failure of clomiphene therapy. None of the patients had mechanical or male infertility factors. The cumulative pregnancy rate (life table method) in Group I patients after six cycles of treatment was 91.2%. In 77 patients from Group I, further treatment was given for a second pregnancy after the first gonadotropin conception. In this group, the cumulative conception rate was 93.6% after eight cycles of treatment. In Group II the cumulative conception rate was 50% after 12 cycles of treatment. In both groups, the results were better in patients who were less than 35 years of age than those who were 35 or more when treated.

Adult↗
PubMed1979

Cell mediated and local immunity to spermatozoa in infertility.

The possibility of the immunological factor as an etiological cause of infertility was investigated in 50 infertile couples. Of these, 31 couples were considered as an "unexplained sterility" group, while in the other 19 couples a variety of disorders were diagnosed. In vitro, leucocyte migration inhibition test (LMIT) was used for the detection of female cell-mediated immunity against sperm antigens. Sperm immobilization test (SIT) and sperm toxicity tests (STT) were used for the detection of antisperm antibodies in the cervical mucus. Out of the 31 "unexplained sterility" cases, six revealed a positive LMIT (5.3%). In 26 couples with an abnormal postcoital test (PCT), 10 cases had a positive SIT and STT (38.5%). However, out of the group of 16 couples with a normal PCT only in one case was a positive SIT and STT found (6.2%). The potential role of immunological reactions in infertility will be discussed.

Antibody Formation↗
PubMed1977

An evaluation of etiologic factors and therapy in 665 infertile couples.

Six hundred and sixty-five unselected infertile couples were investigated and treated in a private clinic during a 15-year span. Male infertility factors were involved in 28%, ovulatory disturbances in 31.5%, tubal factors in 16.3%, and undiscovered factors in 17.6% (117 couples). In 50 couples (7.5%) fertility-reducing factors were found in both partners, with a 14% pregnancy rate, compared with a 54.3% pregnancy rate when only a female factor was involved. The chances of successful treatment of females decline steadily with age, correlating with the fact that the longer the exposure time before the start of treatment, the less the chance of pregnancy. Investigation following 1 year of exposure should be advised. Pregnancy rates were 50% in ovulatory disturbances and 30% with tubal factors. Predictably, a progressive increase in the pregnancy rate was noted during the span of this study.

Adult↗
PubMed1977

[Surgical treatment of caustic esophagogastric stenosis in the chronic phase].

The authors report the results of 26 oesophagoplasties carried out using the descending colon for oesophageal stenosis as a result of a caustic lesion. Superior: in 5 cases the anastomosis being made to the pharynx. Inferior: 8 associated gastric lesions being treated either by resection or by short circuit. The remaining oesophagus was removed in two cases. There were two postoperative deaths. In all the remaining patients a satisfactory functional result was obtained.

Caustics↗
PubMed1971

[Thymectomy].

Explore the source record for details and available documents.

Female↗