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Biomedical subjects

J Donnez

Publications and source records attributed to J Donnez.

At least 163 records · Page 9Linked to original sources
PubMed1982

Peritoneal fluid volume and 17 beta-estradiol and progesterone concentrations in ovulatory, anovulatory, and postmenopausal women.

Data on the volume of peritoneal fluid and the concentrations of estradiol (17 beta-estradiol) and progesterone during the normal menstrual cycle of 158 women are reported and compared with data obtained from women with anovulatory cycles (N = 16), women using hormonal contraceptives (N = 40), and postmenopausal women (N = 6). During the menstrual cycle, the volume of peritoneal fluid increased significantly after ovulation and remained high for at least 10 days, whereas only small quantities were found in women taking oral contraceptives and in women after menopause. During the follicular phase, estradiol and progesterone concentrations in peritoneal fluid were in the same range as the levels in serum. After ovulation (days 14 to 16), the ratios of the hormonal levels in peritoneal fluid and serum, respectively, were 10 for estradiol and 63 for progesterone. The concentrations of estradiol and progesterone in peritoneal fluid were much higher than in serum for at least 1 week after ovulation. The comparison between the different groups suggests that variations in peritoneal fluid during the menstrual cycle are directly related to cyclic ovarian activity. This particular hormonal environment of the ovocyte in vivo has to be considered in future studies on female infertility that focus on maturation and fertilization in vitro.

Anovulation↗
PubMed1981

[Gonadocrinin-like activity of the peritoneal fluid during the menstrual cycle in the normal female].

Peritoneal fluid formation and composition is under the dependence of the ovarian function. Collection of these fluids was performed by laparoscopy in normal cycling women. After absorption of the steroids, they were tested on monolayer pituitary cell cultures in order to study the influence on gonadotrophin release. LH secretion was stimulated through cell the menstrual cycle without any cycling variations. FSH secretion was also increased, excepted in the immediate post-ovulation period. Thus the Peritoneal fluid contains, as follicular fluid, substances with gonadocrinin- and inhibin-like activity. Gonadocrinin activity was not correlated with estradiol and progesterone levels in serum and peritoneal fluid.

Animals↗
PubMed1981

Luteal function after tubal sterilization.

The luteal function in women after tubal sterilization was evaluated and compared with a control group of women of a similar average age. Progesterone measurements and endometrial biopsies were obtained in the midluteal phase (5 to 10 days before the next menstrual period). The group of women who had been sterilized by tubal ligation or electrocoagulation had a significantly lower (P less than or equal to .001) mean midluteal progesterone level (8.5 +/- 6.0 ng/ml) than the group of women who had been sterilized by Hulka-Clemens clips (15.4 +/0 6.3 ng/ml) and the control group (17.2 +/- 4.8 ng/ml). The comparison between these 3 groups on days 19 and 20 and on days 21 and 22 gave the same statistical results. Progesterone levels were lower than 10 ng/ml in 54% of women after tubal ligation or electrocoagulation, whereas such low values were found in only 20% of women after sterilization by Hulka-Clemens clips and in 12% of the women in the control group. A retarded endometrium was observed more frequently in the women who underwent tubal ligation or electrocoagulation than in those who were sterilized by Hulka-Clemens clips. The most likely hypothesis to explain these differences is that sterilization using Hulda-Clemens clips preserves the continuity of the uteroovarian artery.

Body Temperature↗
PubMed1980

[Microscopic study of human fallopian tubes after laparoscopic sterilization (author's transl)].

Histological study was carried out on human fallopian tubes one hour and one month after various methods of laparoscopic sterilization (unipolar electrocoagulation, bipolar electrocoagulation, silicone ring and Hulka-Clemens clip). Microscopic lesions were observed. Ciliated cells were counted. Deciliation is proved at a distance from the site of sterilization. It has been possible to display the substance loss of the tubal tissues which have to be taken into consideration in case of surgical reanastomosis.

Cilia↗
PubMed1980

[Laparoscopic sterilization with the Hulka-Clemens clip. Review of 215 cases (author's transl)].

The application of a modified Hulka-Clemens spring loaded clip to each fallopian tube is a real progress in the fertility control. The operation is quick and easy to perform. The method avoids the dangers of hemorrhage and the complications encountered with other sterilization techniques. The authors give the results by 215 patients. One pregnancy has followed the sterilization procedure. The complications are infrequent in experienced hands.

Adult↗
PubMed1979

Macroscopic and microscopic studies of fallopian tube after laparoscopic sterilization.

Histological study was carried out on human fallopian tubes one hour and one month after various methods of laparoscopic sterilization. Ciliated cells were counted and histological lesions were observed. Deciliation is proved at a distance from the site of sterilization. Taking into account these two data, it has been possible to display the substance loss provoked by each of the usual sterilization methods (unipolar electro-coagulation, bipolar electrocoagulation, silicone ring and Hulka-Clements clip) which have to be taken into consideration in case of surgical re-anastomosis.

Fallopian Tubes↗
PubMedDate not supplied

Livebirth after orthotopic transplantation of cryopreserved ovarian tissue.

BACKGROUND: The lifesaving treatment endured by cancer patients leads, in many women, to early menopause and subsequent infertility. In clinical situations for which chemotherapy needs to be started, ovarian tissue cryopreservation looks to be a promising option to restore fertility. In 1997, biopsy samples of ovarian cortex were taken from a woman with stage IV Hodgkin's lymphoma and cryopreserved before chemotherapy was initiated. After her cancer treatment, the patient had premature ovarian failure. METHODS: In 2003, after freeze-thawing, orthotopic autotransplantation of ovarian cortical tissue was done by laparoscopy. FINDINGS: 5 months after reimplantation, basal body temperature, menstrual cycles, vaginal ultrasonography, and hormone concentrations indicated recovery of regular ovulatory cycles. Laparoscopy at 5 months confirmed the ultrasonographic data and showed the presence of a follicle at the site of reimplantation, clearly situated outside the ovaries, both of which appeared atrophic. From 5 to 9 months, the patient had menstrual bleeding and development of a follicle or corpus luteum with every cycle. 11 months after reimplantation, human chorionic gonadotrophin concentrations and vaginal echography confirmed a viable intrauterine pregnancy, which has resulted in a livebirth. INTERPRETATION: We have described a livebirth after orthotopic autotransplantation of cryopreserved ovarian tissue. Our findings suggest that cryopreservation of ovarian tissue should be offered to all young women diagnosed with cancer.

Adult↗
PubMedDate not supplied

Indications for cryopreservation of ovarian tissue.

For patients who are planning to have chemotherapy, radiotherapy or to undergo bilateral oophorectomy, loss of ovarian function will result in premature ovarian menopause and loss of fertility. For these women, although there is no successful method for the cryopreservation of human oocytes, ovarian tissue cryobanking is proposed with a view to its autotransplantation at a later date or the isolation and in-vitro maturation of oocytes. Embryo preservation is indeed not an option for single women and even for married women because delaying treatment for at least 2 months of in-vitro fertilization cycles is inappropriate and life-threatening. Following the success of animal experiments, there have been reports of ovarian cryopreservation for women having to receive chemotherapy and/or radiotherapy. We present four case reports of ovarian tissue cryobanking and review the consequences of chemotherapy and radiotherapy on gonadal function, as well as the indications for freezing ovarian tissue.

Adenocarcinoma↗
PubMedDate not supplied

Laparoscopic myolysis.

This review will focus on the different techniques and the long-term effects of the technique called myolysis on myoma growth. Indications for myolysis are essentially pelvic pain, compression symptoms and global uterine volume in order to avoid hysterectomy. In the late 1980s, myolysis was performed laparoscopically with the help of the neodynium: yttrium aluminium garnet (Nd:YAG) laser. Later, bipolar needles were developed as an alternative to the Nd:YAG laser. Diathermy and cryomyolysis were also proposed but series are small in the literature. Very recently, myoma interstitial thermo-therapy (MITT) was performed using the diode laser and a specific optical light diffuser that is designed to transmit laser light in all directions. Laparoscopic myolysis was proved to be effective in provoking myoma shrinkage, with a dramatic decrease in size and a marked devascularization of the myoma and this technique can be proposed as an alternative to myomectomy in selected patients: only those aged >40 years or those not desiring to bear any more children.

Cryosurgery↗
PubMedDate not supplied

First-trimester diagnosis of conjoined twins.

Two cases of conjoined twins were diagnosed during first-trimester endovaginal ultrasound and were confirmed by embryoscopy performed prior to the termination of pregnancy. An early and accurate diagnosis of this anomaly, obtained by the combined use of ultrasound and endoscopy, may enable adequate counselling and an earlier termination of pregnancy associated with minimal maternal risks.

Abnormalities, Multiple↗