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Biomedical subjects

J Donat

Publications and source records attributed to J Donat.

23 records · Page 2Linked to original sources
PubMed1982

[Epidemiology of leukemia in children in Valencia (author's transl)].

The incidence of leukemia in Valencia in children zero-seven years old, during a period of ten years (1970-1979), is studied. One hundred and fifty five cases of leukemia were diagnosed on five hospitals during this time. This makes an incidence of 3.5 cases per 100,000 children and years. A light predominance of males was observed and the peak age of presentation was between two and five years. Acute lymphoblastic leukemia was the more frequent variety, followed a big distance by acute myeloid. The relation with other factors, as chromosome abnormalities, parents age, socioeconomic level, are also studied.

Age Factors↗
PubMed1982

[Immunity in hypothyroid children (author's transl)].

For a long time investigators have focused attention on the relationship between specific immunity and hormones. In the present paper, authors investigated on 26 children, 9 males and 17 females, from 9 months to 14 and 10/12 years old, with primary hypothyroidism. All patients were in substitutive treatment. The following studies were done to all the patients: serum IgG, IgA, IgM and complement. Blood lymphocyte counts, percentages of B and T lymphocytes, as well as the response of lymphocytes to PHA. Skin tests were also carried out: tuberculin, candidin and streptokinase-streptodornase. All results obtained in both, hypothyroid and control groups fell within the range of normal age-matched values for our laboratory, and by results of statistics studies carried out they were considered of little significance, except the percentage of circulating B lymphocytes that was lower in hypothyroid group (p less than or equal to 0.01).

Adolescent↗
PubMed1976

[Pulmonary disease during mtx therapy in a.l.l. (author's transl)].

Authors describe three cases of pulmonary disease showed in three children with acute lymphoblastic leukemia during maintenance therapy with Methotrexate (MTX) (Dose: 30 mg/sm/W). The initial symptom occurs in the lapse between 40 and 135 days within the first MTX maintenance period and in 35 days in the second maintenance period. Leukopenia with eosinophilia (192-264 eosinophils/mm3) occurs in case 1. The maintenance of the MTX therapy in this case ends with death of the patient. Radiological studies show basal bilateral pulmonary infiltrations, with pleural involvement in one case. Authors insist in the drug (MTX) suppression as main therapy and agree with the opinion of some authors concerning to the 31 cases previously published.

Child↗
PubMedDate not supplied

Charcot-Marie-Tooth disease.

OBJECTIVE: To discuss the similarities and differences in the clinical presentation of Charcot-Marie-Tooth Disease, an inherited peripheral neuropathy, and acquired lumbar spinal stenosis. CLINICAL FEATURES: Patients with lumbar spinal stenosis causing nerve root entrapment often have leg pain and weakness during such activities as walking or standing. Additional symptoms of poor balance, foot deformity and signs of cerebellar and sensory ataxia suggest a diagnosis of peripheral neuropathy rather than nerve root entrapment. INTERVENTION: Electrodiagnostic testing and nerve conduction studies reveal abnormal conduction velocities in cases of peripheral neuropathy such as Charcot-Marie-Tooth Disease. CONCLUSION: Sciatica and leg weakness may be due to a variety of causes, including nerve root entrapment and peripheral neuropathy. A diagnosis of Charcot-Marie-Tooth Disease should be considered in a case of progressive lower limb weakness associated with loss of balance and sensory ataxia. This diagnosis can be confirmed using nerve conduction studies.

Charcot-Marie-Tooth Disease↗