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Biomedical subjects

J Domingo

Publications and source records attributed to J Domingo.

50 records · Page 3Linked to original sources
PubMed1984

Quantitative and qualitative changes of plasma membrane glycoproteins in the early period of liver regeneration.

Alterations of cell surface glycoconjugates have been observed in many developing systems and may be important in the physiological control of growth and differentiation. Liver regeneration after partial hepatectomy is a suitable model in which to study the regulatory mechanisms of cell proliferation in vivo. We have isolated the sinusoidal plasma membrane of hepatocytes at different times after partial hepatectomy. The sialic acid content and the SDS-polyacrylamide gel electrophoresis pattern of glycoproteins were determined. A decrease of periodic acid-Schiff-profiles, a change in the binding capacities of 125I-concanavalin A, a reduction of the sialic acid content and the appearance and disappearance of specific components have been observed during the pre-replicative phase of liver regeneration. These findings during this early period are consistent with the active involvement of the plasma membrane glycoproteins in the transition of cells to the proliferative state.

Animals↗
PubMed1984

Wright's stain in rapid diagnosis of Pneumocystis carinii.

The conventional Hematology Wright's stain has been used in touch preparation from open lung biopsies to identify Pneumocystis carinii. A 100% positive correlation has been found using this rapid and readily available technique when compared to the conventional silver stain and permanent histologic sections.

Humans↗
PubMed1984

Enzyme pattern and growth rate of liver preneoplastic clones during carcinogenesis by diethylnitrosamine.

Enzyme biochemical and histochemical assays during chemical carcinogenesis in rat liver have revealed that several adult enzyme activities are lost and some fetal enzyme activities are re-expressed in the hyperplastic foci as well as in the developed hepatomas. How these enzyme alterations are acquired and to what extent these changes are specifically related to the growth alterations leading to neoplastic development are decisive questions. Using a carcinogenesis protocol that combines a single dose of diethylnitrosamine and phenobarbital given continuously as the promoting agent and by assaying serial liver sections for glucose-6-phosphatase, adenosine-5'-triphosphatase and 5'-nucleotidase, we have identified the three-enzyme pattern of 1,746 islands and measured their section areas. We found a clear trend that clones with more deviated enzyme pattern grow faster than less deviated ones.

5'-Nucleotidase↗
PubMed1983

Remission of rapidly growing desmoid tumors after tamoxifen therapy.

A patient is described with Gardner's syndrome manifested initially by an extra-abdominal desmoid which was resected. The case was complicated by metastatic adenocarcinoma of the colon and recurrence of several large painful desmoid lesions. In view of the predilection of desmoids to occur in women in their childbearing years, it was decided to treat these painful lesions with an anti-estrogen, tamoxifen (20 mg orally, four times daily). This therapy led to a complete relief of pain within 1 week and a progressive decrease in the size of the desmoid tumors to less than 50% of their initial volume by the end of the second week. Unfortunately, the patient's metastatic adenocarcinoma progressed and was complicated by sepsis leading to her death. This case suggests that the growth of desmoid tumors is under hormonal influence, a suggestion which deserves further investigation.

Adenocarcinoma↗
PubMed1983

Lymphadenopathy in a heterogeneous population at risk for the acquired immunodeficiency syndrome (AIDS)--a morphologic study.

The acquired immunodeficiency syndrome (AIDS) appears to be expanding both in the population at risk and in its clinical form of presentation. Persistent generalized lymphadenopathy has been reported in homosexual men who have immunologic abnormalities associated with AIDS. We are reporting ten cases of unexplained persistent generalized lymphadenopathy that have occurred in a heterogeneous population group at risk for AIDS (homosexual men, drug addicts, or Haitians). The morphologic findings of reactive follicular hyperplasia, increased interfollicular cellularity including an abundance of plasma cells and immunoblasts, preservation of the sinuses containing a sprinkling of polymorphonuclear leukocytes, and occasional multinucleated lymphoid cells constitute a constellation of features that are consistent enough so that AIDS should be included in the differential diagnosis.

Acquired Immunodeficiency Syndrome↗
PubMed1983

[Enzymatic phenotype of preneoplastic islands induced in the rat liver by diethylnitrosamine].

Diethylnitrosamine was injected to Sprague-Dawley rats after a partial hepatectomy, and enzyme histochemistry analysis was made after 35 weeks in the preneoplastic liver. The areas and volumes of the induced enzyme-deficient islands were calculated for glucose-6-triphosphatase, adenosine triphosphatase, and 5'-nucleotidase. The preneoplastic enzyme-deficient zones showed also an increased incorporation of tritiated thymidine.

5'-Nucleotidase↗
PubMed1982

Cryptococcal osteomyelitis. Report of a case amd a review of the literature.

A case is reported of isolated cryptococcal osteomyelitis in an 11-year-old girl without any detectable underlying disease. The patient was successfully treated for six weeks with intravenous amphotericin B and oral 5-flucytosine. There is only one other case of cryptococcal osteomyelitis reported in the English medical literature in a child. Over 50 per cent of individuals with this infection will have an underlying condition which may have predisposed them to acquiring this disease.

Amphotericin B↗
PubMed1979

Malignant neoplasms associated with nevus sebaceus of Jadassohn.

Nine patients with nevus sebaceus of Jadassohn (NSJ) developed associated morphologically aggressive neoplasms. Four of the tumors were apocrine carcinomas, two of which metastasized to regional lymph nodes, and in one of the two generalized metastases developed. Three tumors were adnexal carcinomas with probable pilar differentiation, but none showed progression of the disease after wide surgical excision. One patient has squamous cell carcinoma and died with generalized metastasis, and one patient had a complex adnexal and squamous cell carcinoma with a large area of anaplastic carcinoma that recurred and invaded the skull.

Adenocarcinoma↗