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Biomedical subjects

J Dobrowolski

Publications and source records attributed to J Dobrowolski.

78 records · Page 5Linked to original sources
PubMedDate not supplied

Selenium effect on the growth of carcinogenic fungi and cytotoxic action of aflatoxin B1 on lymphocyte culture and on embryonal development of Xenopus laevis.

The authors report the results of investigations on the protective effect of selenium against teratogenic and cytotoxic action of aflatoxin B1 and the inhibitory action of this element on the growth of fungi producing carcinogenic aflatoxins. Sodium selenate inhibited the growth of cultures of such fungi belonging to the class Fungi imperfecti as Aspergillus flavus, Aspergillus fumigatus, Penicillium meleagrinum and Penicillium rougolosum. Added to cell cultures of lymphocytes sodium selenate inhibited the cytotoxic action of aflatoxin B1 evidenced by inhibition of PHA-stimulated blastic transformation of these cells and reduction in the number of mitoses. Sodium selenate added to the medium in the culture of Xenopus laevis larvae poisoned with aflatoxin B1 reduced significantly the early mortality of embryos and counteracted the teratogenic action of aflatoxin B1. This action was observed, however, only in early phase of morulation. The authors discuss the importance of their observations for the studies on the role of bioelements deficiency in the environment for induction of malignant transformation.

Aflatoxins↗
PubMedDate not supplied

[Personal studies of threshold values in planimetric measurements of pulmonary pressure].

Assessment of the pulmonary pressure is of importance in cardiopulmonary diseases, the most exact data are achieved with direct measurements. However, this invasive technique, which is rarely available. Therefore, the authors have elaborated the radiological technique of pulmonary pressure assessment, based on chest X-rays. Eighty patients were examined radiologically, and pulmonary pressure was evaluated planimetrically by measurements of the intermediate artery and both arteries of the anterior upper segments diameters on X-ray. These results were compared with the measurements obtained with microcatheterization technique. The authors recommend planimetric measurements for usual practice and screening of larger number of patients.

Adult↗
PubMedDate not supplied

[Effect of calf thymus extracts on the surface structure and the lysosomal apparatus of lymphocytes in patients with chronic lymphatic leukemia].

In 6 patients with chronic lymphatic leukaemia receiving subcutaneously purified calf thymus extract a greater frequency of the following processes was observed: 1) increase in the number of smooth-surface lymphocytes (T cells) in scanning electron microscopy, 2) increased number of lymphocytes forming rosettes with uncoated sheep erythrocytes, 3) increased number of lymphocytes showing high activity of acid phosphatase in cytochemical investigations.

Acid Phosphatase↗