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Biomedical subjects

J Dobroschke

Publications and source records attributed to J Dobroschke.

35 records · Page 2Linked to original sources
PubMed1980

[Complications following thoracic surgery (author's transl)].

From 1968--1977 a total of 2,670 patients with thoracic injury or disease were treated in the Department of General and Thoracic Surgery at the University of Giessen. Of these, 1,185 patients were operated on: 701 lung resections, 371 thoracotomies, and 113 operations on the diaphragm and thoracic wall. Postoperative complications were observed in 16% and 8% died. Frequency and severity of the complications were dependent on the type of surgery and the underlying disease.

Adolescent↗
PubMed1980

Islet transplantation in experimental diabetes of the rat. VII. Cryopreservation of rat and human islets. Preliminary results.

Islet transplantation in human diabetes at present is confronted with two major obstacles: isolation of a sufficient number of islets and islet graft rejection. "Tissue banking" would enable islet pooling from various donors and offers furthermore the advantage of in vitro manipulations in order to reduce islet immunogenicity. Recently we have reported successful cryopreservation and subsequent transplantation of porcine islets (Bretzel, Beule, Schäfer, Schneider, Pfeiffer and Federlin 1979). These preliminary data deal with cryopreservation and transplantation of isolated rat islets and cryopreservation of isolated human islets.

Animals↗
PubMed1980

[Somatostatin in small intestine fistulas].

Somatostatin (GIF) was administered to a patient with persisting intestinal fistulas. Somatostatin reduced the tryptical activity of the secretions which subsequently subsided.

Adult↗
PubMed1980

[Surgical treatment of lung abnormalities].

Four cases of lung malformations are presented. In this cases symptoms, diagnostic procedures, indications for operation and surgical treatment are discussed. Agenesis and aplasia of lungs do not require surgical treatment. Hypoplasia of the lung, an accessory lung and sequestrations leading to purulent-recurrent infections can be treated by resections.

Adolescent↗
PubMed1980

[Advantages of a new thoracic drainage unit with double sealing].

The paper deals with the application of a new 'Four-Compartment Drainage System' with double-sealing in 20 patients having lung parenchyma resections, explorative thoracotomies, and pneumothorax. This drainage system has an advantage over conventional intercostal drainage in as much as it prevents tension pneumothorax in leakage of the lung and suction failure. The closed system avoids bacterial contamination of the pleural space.

Drainage↗
PubMed1979

[Autotransplantation of Langerhans' islets in a case of total duodenopancreatectomy (author's transl)].

A 36-year-old man suffering from chronic pancreatitis involving the whole organ had total duodenopancreatectomy. The Langerhans' islets were isolated from the extirpated organ and transplanted into the liver via portal artery. Insulin substitution could be lowered from 50 I.U. to 12 I.U. by the 5th post operative day. Repeatedly, raised insulin levels could be verified in response to high blood sugar loads. C-peptide and glucagon were also found. 7 months after transplantation the islets still seem to be functioning.

Adult↗
PubMed1978

[Autotransplantion of Langerhans islets after total duodeno-pancreatectomy in a patient with chronic pancreatitis (author's transl)].

Total duodenopancreatectomy was performed in a 36-year-old man because of global chronic pancreatitis. Islets cells were isolated by collagenase digestion from the resected pancreas and re-implanted into the liver via the portal vein. Until the sixth postoperative day the amount of insulin required fell from 54 IU initially to 10 IU per day. Serial insulin determination demonstrated secretion by the implanted cells.

Adult↗
PubMed1978

[Results of treatment in early carcinoma of the stomach].

From 1961 to 1975, 53 patients were operated on for early carcinoma of the stomach, 24 or the total of 57 cancer sites being limited to the mucosa, 33 having already infiltrated into the submucosa. Macroscopically, most of them were ulcerative carcinoma, while histologically the intestinal type predominated. The cumulative five-year survival rate (excluding hospital deaths) was 86.5%, while after "typical" carcinoma resection by the Billroth II procedure with removal of the greater and lesser omentum it was 100% for mucosal and 93% for submucosal carcinoma.

Adult↗
PubMed1976

[Results of surgical treatment of early carcinoma of the stomach (author's transl)].

From 1961 to 1975, 53 patients were operated on for early carcinoma of the stomach, 24 of the total of 57 cancer sites being limited to the mucosa, 33 having already infiltrated into the submucosa. Macroscopically, most of them were ulcerative carcinoma, while histologically the intestinal type predominated. The cumulative five-year survival rate (excluding hospital deaths) was 86.5%, while after "typical" carcinoma resection by the Billroth II procedure with removal of the greater and lesser omentum it was 100% for mucosal and 93% for submucosal carcinoma.

Adult↗
PubMed1975

[Results of palliative operations concerning the gastrointestinal tract].

At the Surgical Clinic of the University Erlanten-Nürnber 61 per cent of the carcinoma of the oesophagus, 57 per cent of malignant tumors of the stomach and 28 per cent of all tumors of the large bowel and the rectum could not be operated radically. If there are no metastases in other organs or a wide-spread peritoneal dissemination a palliative procedure is advisable. Resection of the tumor itself has been the most effectful prodedure in cases of palliative treatment. Gastrostomies, bypass-anastomoses and protheses have been comparatively less successful. Radiation is indicated only in cases of squamoun cell-carcinoma of the oesophagus. In cases of the carcinoma of the rectum located in the middle and lower part causing a severe stenosis coagulation is an effective treatment.

Aged↗