Blastic transformation associated with 5q- and 12p-.
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
J Dobbin
Publications and source records attributed to J Dobbin.
Seroepidemiologic survey for antibodies to human retroviruses in human and non-human primates in Brazil.
The prevalence of antibodies to HTLV-I and HIV-I in Brazil was determined by testing sera from: (a) 119 members of an isolated Amazonian community of African origin; (b) 100 voluntary blood donors in Rio de Janeiro; (c) 215 patients treated at the Hematology Service, National Cancer Institute, Rio de Janeiro, and (d) 44 Cebus apella New World monkeys, wild-caught in Amazonia. Anti-HTLV-I was detected in 1 (0.84%) of 119 Amazonians, in 8 (3.72%) of the 215 patients and in none of the blood donors or monkeys. The high prevalence found in patients included 4 (5.79%) of 69 with non-Hodgkin lymphoma, 2 (5.88%) of 34 with Hodgkin lymphoma, 1 (16.66%) of 6 patients with diagnosis of anemia and 1 (20%) of 5 with HIV-I infection. Anti-HIV-I was found in 7 (14.89%) of 47 patients and in none of the other groups. The high incidence of HTLV-I infection in the patient group suggests that this retrovirus is endemic in parts of Brazil.
Adult↗
Transient blood-brain barrier permeability following profound temporary global ischaemia: an experimental study using 14C-AIB.
The influence of reperfusion after profound incomplete forebrain ischaemia on blood-brain barrier (BBB) permeability to a small protein tracer was studied in male Sprague-Dawley rats. The mean cortical blood to brain transfer constant (Ki) for 14C-amino isobutyric acid (AIB) was significantly greater at 3 and 6 h of reperfusion, 2.5 times the mean values of controls (p less than 0.05) (2.5 microliter g-1 min-1 and 1.0 microliters g-1 min-1 respectively), but had returned to control values after reperfusion for 24 h. Analysis of distribution of Ki values showed that following 15 min and 30 min of profound ischaemia, there was a significant increase in transfer of AIB across the blood-brain barrier (BBB) after recirculation for up to 6 h, though there was no evidence of protein extravasation as assessed by Evans Blue (EB) dye. After 24 h of reperfusion, the BBB to AIB was restored, and Ki values had returned to control values. It is concluded that following transient global ischaemia, the BBB may recover rapidly.
Aminoisobutyric Acids↗
Massive epistaxis from nasal CPAP therapy.
A 75-year-old man with obstructive sleep apnea and secondary right heart failure was started on nasal CPAP therapy. Shortly thereafter he experienced massive life-threatening epistaxis requiring nasal packing and hospitalization. The epistaxis was thought to be due to the drying effect of nasal CPAP.
Aged↗
19F imaging of cerebral blood oxygenation in experimental middle cerebral artery occlusion: preliminary results.
Fluorine (19F) nuclear magnetic resonance may be used to image cerebral perfusion in cats receiving perfluorocarbon blood substitutes. 19F relaxation times in these blood substitutes are dependent on oxygen tension (PO2) and may be used to calculate and spatially map cerebrovascular PO2 values in vivo. We have applied this noninvasive method to experimental middle cerebral artery (MCA) occlusion. Following MCA occlusion a perfusion defect is evident in the sylvian region, followed by the appearance of collaterals. Signal from the ipsilateral rete mirabilis is increased. Calculated cortical vascular PO2 values indicate a relative reduction in oxygenation in the ischaemic hemisphere. PO2 maps show a perfused hypoxaemic zone adjacent to the perfusion defect. These changes are partly reversed with reperfusion.
Animals↗
Diurnal variations in proliferation and crypt survival suggest a small target cell population in mouse colon.
Explore the source record for details and available documents.
Aging↗
The validity of the labelling index in tumour studies.
The distribution of labelled cells through 5 different mouse tumours was measured after a single injection of [3H]-thymidine [( 3H]-TdR) or [3H]-deoxyuridine [( 3H]-UdR). All the tumours had areas where the percentage of labelled cells (the labelling index, LI) was high and areas where the LI was very low. The total area with a low LI was greater after [3H]-TdR than after [3H]-UdR injection in all 5 tumours. In one of the tumours, carcinoma NT, repeated injections of [3H]-UdR at 2 h intervals caused the areas of high LI to spread, eliminating all areas of low LI in many specimens. When 5-fluorodeoxyuridine (FUdR) was injected, to block de novo DNA synthesis in carcinoma NT, [3H]-TdR was incorporated by many more cells. The LI was increased throughout the tumour and no area had a LI below 20% after FUdR plus [3H]-TdR. After flash-labelling with [3H]-TdR alone, nearly half the tumour had a LI below 20%. We conclude that the labelling seen after FUdR plus [3H]-TdR represented the true distribution of S phase cells in carcinoma NT. Routine flash-labelling with [3H]-TdR or [3H]-UdR left nearly half the S phase cells unlabelled and gave an erroneously low value for the proportion of DNA synthesising cells in the tumour. The results suggest that many tumour cells have very large endogenous nucleotide pools which cannot be flooded by a single injection, even of [3H]-UdR.
Animals↗