Biomedical subjects
Publications and source records attributed to J Dittrich.
Human colonic adenylate cyclase has been shown to be sensitive to vasoactive intestinal polypeptide (VIP) and prostaglandins of the E- and F-type. Maximal activation of enzyme activity averaged 200% for VIP and 300-350% for the E-prostaglandins. Both classes of hormones had an additive effect on enzyme activity indicating the existence of two distinct hormone-sensitive adenylate cyclases in human colonic mucosa.
RMI 12330 A, a compound of the lactamamide series, is a potent inhibitor of vasoactive intestinal polypeptide(VIP)- and prostaglandin (PG)-stimulated colonic secretion in the rat. This substance was tested on the adenylate cyclase system in human colonic mucosa. RMI 12330 A inhibited PGE2-, 16,16-dimethyl-PGE2- as well as VIP-sensitive adenylate cyclases in a dose-related manner. Half-maximal inhibition of hormone-stimulated enzyme activities occurred at a lactamimide concentration of about 0.15 mM. Lactamimide inhibition was non-competitive. Our results are compatible with the concept of RMI 12330 A acting as an inhibitor of colonic secretion via inhibition of hormone-sensitive adenylate cyclase. Since basal, NaF- and guanylyl-imidodiphosphate-stimulated enzyme activities were also affected by this compound, we may conclude that RMI 12330 A is a non-specific inhibitor of the human colonic adenylate cyclase system.
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Among the acquired defects of ventricular septum the rupture of the septum are known to occur as a rare complication following penetrating and non-penetrating injuries of the chest and more common as sequel of myocardial infarction. A left to right shunt usually follows the acute rupture of the interventricular septum, and is usually lethal. Only a few patients survive for several months under conventional therapy. Early diagnostic procedures using heart catheterization are crucial to determine whether surgical maneuvers are necessary. We present patients who experienced acute rupture of the ventricular septum. We discuss their pathological and clinical findings as well as the problems related to prognosis and therapy.
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Modern longterm electrocardiography (telemetry, tape recorder) permits the simultaneous recording of heart rate and arrhythmias and analysis of the QRS complex and ST-T sections. "Paroxysmal tachycardia" in different stress situations and the telemetric electrocardiograph tracing must be interpreted taking into consideration additional findings of clinical cardiological examinations. Of 82 subjects, 30 with the symptom "tachycardia" with familial and/or occupational stress could be subdivided into three disease groups: Group A: autonomic lability of healthy hearts; Group B: patients with pre-excitation syndrome; Group C: organic heart disease patients.
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