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Biomedical subjects

J Dewhurst

Publications and source records attributed to J Dewhurst.

At least 37 records · Page 2Linked to original sources
PubMed1982

Psychophysiological ante-natal predictors of post-natal depressed mood.

Forty-seven women were studied during the course of pregnancy in an attempt to predict which of them would later rate themselves as suffering from depressed mood post-natally. Psychometric and physiology measures were used in the three trimesters of pregnancy and six weeks after birth. The psychometric measures used ante-natally and post-natally comprised the Hostility and Direction of Hostility Questionnaire, and Locus of Control Scale, the DSSI/SAD sub-scale to measure anxiety, and the Zung Self-Rating Scale to measure depression. Psychophysiological measures used water heart-rate and blood pressure. Post-natal ratings of depression were associated with a high ante-natal score on overall hostility. Women with high anxiety and hostility ratings had a more pronounced response to the sound of a baby crying than to noise of similar frequency and intensity. This more pronounced heart response was also related to later post-natal depression ratings. However, by far the most useful predictive measure was the Hostility and Direction of Hostility Questionnaire: its predictive power in the first trimester of pregnancy was almost as good as in the third trimester.

Anxiety↗
PubMed1982

Predictive value of ultrasound measurement in early pregnancy: a randomized controlled trial.

Early fetal biparietal diameter (BPD) measurements were obtained with ultrasound in 1062 women attending for antenatal care; a random half had the results withheld from the obstetricians. Of the 1026 women who were sure of the dates of their last normal menstrual period, 829 (81%) were found to have appropriate biparietal diameter measurements, in 3% the pregnancy was more than 2 weeks further advanced and in 14% more than 2 weeks less than calculated. In 30% of the women whose results were intended to be withheld, the code had to be broken because of clinical concern. There were no differences in fetal outcome (birthweight centile, Apgar score at 1 min and perinatal mortality) in the women whose BPD results were known compared with those whose results were withheld from the obstetrician. But a significantly larger number of labours were induced for suspected growth retardation when the gestational age was known.

Clinical Trials as Topic↗
PubMed1980

Decreased urinary output of conjugated tyramine is associated with lifetime vulnerability to depressive illness.

In a group of normal pregnant women whose psychiatric histories were unknown, those with the lowest output of urinary tyramine (free plus conjugated) after an oral tyramine load had a significantly higher lifetime incidence of depressive illness compared with those with the highest output. as none of the women were suffering from depression at the time of tyramine loading, it seems likely that this decreased excretion of tyramine is associated in some way with vulnerability to depressive illness, whether puerperal or nonpuerperal.

Chronic Disease↗
PubMed1980

Ivalon sponge hysterosacropexy for genital prolapse in patients with bladder extrophy.

Two patients with bladder extrophy are presented. Both had had corrective surgery in childhood and subsequently presented with recurrent procidentia after a previously unsatisfactory repair operation. Both were treated by hysteroscaropexy (a new procedure) which is described in detail and when reviewed 12 months later were symptom-free with good genital tract support.

Adolescent↗
PubMed1980

Plasma prostaglandin concentrations after cerclage in early pregnancy.

A prospective, randomized controlled study was made to measure the circulating levels of 13, 14-dihydro-15-keto-prostaglandin F (PGFM) in two groups of women having cervical cerclage early in the second trimester of pregnancy. One group of patients was given omnopon by intramuscular injection for 24 hours after operation and the other salbutamol by intravenous infusion. A significant rise in circulating PGFM was found in both groups after cervical cerclage and the magnitude of the rise was similar in the two groups; levels of PGFM in both groups had returned to the preoperative levels within 24 hours of operation. The levels of PGFM before and after operation showed no relation to the eventual outcome of the pregnancy, which was successful in 80 percent of patients.

Albuterol↗