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Biomedical subjects

J Devillers

Publications and source records attributed to J Devillers.

38 records · Page 3Linked to original sources
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Comparative toxicity and hazards of pesticides to Apis and non-Apis bees. A chemometrical study.

The adverse effects of 158 pesticides to the Honey bee (Apis mellifera), the alfalfa leafcutting bee (Megachile rotundata) and the alkali bee (Nomia melanderi) were compared by means of various linear and non-linear multivariate analyses. A comparison exercise including the bumble bee (Bombus spp.) was also performed from a more restricted set of 32 pesticides. While no difference of sensitivity was found between A. mellifera and Bombus spp., M. rotundata appeared the most susceptible to pesticides followed by N. melanderi.

Animals↗
PubMedDate not supplied

Prediction of mammalian toxicity of organophosphorus pesticides from QSTR modeling.

Quantitative structure-toxicity relationship (QSTR) models were derived for estimating the acute oral toxicity of organophosphorus pesticides to male and female rats. The 51 chemicals of the training set and the nine compounds of the external testing set were described by means of autocorrelation vectors encoding lipophilicity, molar refractivity, H-bonding acceptor ability (HBA) and H-bonding donor ability (HBD) of the molecules. A feature selection was employed for selecting the most relevant autocorrelation descriptors. A PLS regression analysis and an artificial neural network (ANN) were used for deriving models accounting for the sex of the organisms in the estimation of the toxicity of pesticides. The best results were obtained with an 8/4/1 ANN model trained with theback-propagation and conjugate gradient descent algorithms. The root mean square residual (RMSR) values for the training set and the external testing set equaled 0.29 and 0.26, respectively.

Animals↗