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J Descotes

Publications and source records attributed to J Descotes.

At least 289 records · Page 16Linked to original sources
PubMedDate not supplied

[The caffeine test].

The inhibition of oxidative drug metabolism is a major cause of clinically significant drug interactions. Among the possible modalities for exploring the enzyme inhibiting potential of drugs, the caffeine test is a valuable addition to the antipyrine test in man. Indeed, microsomal enzymes explored by the caffeine test differ from those attainable by the antipyrine test. After a short overview of caffeine pharmacokinetics, the features of the caffeine test are tentatively described. The results of published studies indicate the usefulness of this simple test for detecting those new drugs endowed with an enzyme inhibiting potential.

Animals↗
PubMedDate not supplied

Time dependent modifications in arterial flow in a transplanted pulmonary lobe.

Study of pulmonary arterial flow in the transplanted lung by means of an implanted ultrasonic flowmeter enables us: 1. To confirm results obtained by other methods (De Bono,8 Strider14 and Strandberg18): without specific treatment, rejection of graft causes increased peripheral resistances and the pulmonary arterial flow decreases progressively. 2. To prove by direct observation the existence in the treated animal of authentic precapillary shunts whose importance can cause the animal's death through functional disorder alone.

Animals↗
PubMedDate not supplied

[Chemotactic response of human polynuclear neutrophils after in vivo administration of spiramycin].

The chemotactic response of polymorphonuclear leukocytes using the agarose method, has been studied in six healthy volunteers, immediately prior and after a 5-day oral administration of spiramycin, 6 million units per day. The influence of spiramycin proved to be small as the directed and spontaneous migration were decreased by 21% and 18% respectively. Despite the fact that spiramycin can penetrate into leukocytes, these results indicate that no clinically relevant alterations of chemotaxis are likely under therapeutic conditions.

Adult↗