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Biomedical subjects

J Descotes

Publications and source records attributed to J Descotes.

At least 181 records · Page 10Linked to original sources
PubMed1978

[Mechanism of biosynthesis of glycoconjugates at the level of the arterial walls after contact with alloplastic materials (author's transl)].

The object of this work was to show that here exists after contact with foreign substances, a construction of protein, glycoprotein and mucopolysaccharide macromolecules at the level of the intima of the great vessels. Woven Dacron prostheses have been implanted in the arterial circulation of dogs (on the subrenal abdominal aorta). After removal of vascular segments, we carried out a subcellular fractioning, controlled and studied in an acellular system in vitro the activity of the glycosyltransferases implied in the construction of glycan chains of glyccproteins. The results are discussed in relation to the duration of implantation of the prosthesis. The modifications observed differ according to the position of the sugars in the glycan chains, in particular as far as sialic acid is concerned, and lead to an interpretation of the mechanism of endovascular reactions when faced with foreign material.

Animals↗
PubMed1978

Mechanism of glycoconjugates biosynthesis in the vascular wall with external circular constraint.

Extrinsic local constraints, realised on dogs aorta are responsible for parietal lesions in the form of thickening of the arterial wall. Histological changes in the intima and media are characteristic of processes of degeneration destruction and cellular regeneration, superposed on sub-endothelial proliferation accompained by partial or total destruction of endothelial cells in the intimal layer. In addition to histological changes, there were perturbation in enzymatic activities of glycosyltransferases responsible for macromolecular constructions in the intima. Microsomic enzymes studied were: N-acetyl-glucosaminyl-transferase, sialyl-transferase and N-acetyl-galactosaminyl-transferase, and two glycosyl-transferases located in the soluble cytoplasmic phase: fucosyl and xylosyl-transferase. The changes observed were different according to the position of the sugars in the glycoprotein chains. For example the variation of fucosyl-transferase activity is significant: it disappears in group where the sialyl-transferase activity is enhanced. The transfer of xylose is decreased. Finally, changes observed in hexosaminyl-transferase activities were parallel.

Animals↗