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Biomedical subjects

J Dequeker

Publications and source records attributed to J Dequeker.

At least 289 records · Page 16Linked to original sources
PubMed1978

Familial occurrence of severe ulnar aplasia and lobster claw feet: a new syndrome.

In this paper we describe a previously unreported association of ulnar defect and lobster-claw deformity of the feet, occurring in four males belonging to two generations of the same family. Minor expression of the same ulnar reduction defect in female relatives suggests X-linked recessive inheritance, but an autosomal dominant with irregular expression cannot be excluded.

Abnormalities, Multiple↗
PubMed1978

The effect of long-term oestrogen treatment on the development of osteoarthrosis at the small hand joints.

The effect of long-term oestrogen treatment of at least 5 yr on the development of osteoarthrosis was studied in 48 postmenopausal women. Osteoarthrosis at the hand joints was graded according to Kellgren's criteria, using hand X-rays. Data obtained in a normal population of 155 women served as controls as well as data obtained in 24 postmenopausal women who didnot receive oestrogen replacement therapy. No significant difference in osteoarthrosis between the treated and non-treated groups was found. The development of osteoarthrosis at the hand joints seems to be independent of the hormonal status in postmenopausal women.

Aged↗
PubMed1978

Evaluation of sacro-iliitis: comparison of radiological and radionuclide techniques.

A 99mTc count profile of the sacro-iliac region was performed in 14 control subjects and in 50 patients with inflammatory pain of the sacro-iliac joints. In addition, 85mSr count profiles were recorded in 14 control subjects. The sacro-iliac/sacral uptake ratio was calculated. There was no significant difference between Sr and Tc count profiles. The uptake in patients with sacro-iliitis was not above the range for controls. The mean uptake ratio was significantly below that for controls, and was lower in cases with radiologically advanced changes than in those with few or no signs. This method was not useful for early diagnosis of sacro-iliitis.

Adolescent↗
PubMed1978

Double-blind trial comparing bufexamac infiltrations with triamcinolone acetonide infiltrations in patients with periarthritis of the shoulder.

A double-blind trial was carried out in 40 patients with an acute episode of periarthritis of the shoulder to compare the effectiveness and toleration of local infiltrations of bufexamac and triamcinolone acetonide. Patients received 1 or 2 local infiltrations with either 20 mg bufexamac or 40 mg triamcinolone acetonide. The results were evaluated by objective and subjective assessments of pain, loss of function, mobility, and by doctors' and patients' opinions of relief. There was a significant, comparable reduction in pain and discomfort in both groups after the first injection. Fourteen patients in each group required a second injection, with slightly more improvement in those receiving bufexamac. Local intolerance of the injections was noted in approximately 25% to 30% of the patients.

Adult↗
PubMed1978

Oxaprozin versus aspirin in rheumatoid arthritis: a double-blind trial.

A parallel double-blind trial was carried out over a 3-month period in 40 patients suffering from active rheumatoid arthritis to compare the anti-inflammatory effectiveness and side-effects of treatment with oxaprozin and aspirin. The results showed that 1200 mg oxaprozin daily had similar anti-inflammatory properties to those of 3.9 g aspirin daily in rheumatoid arthritis. Better results were produced with 1200 mg oxaproxin daily than with a 600 mg dosage level, suggesting that there is a close dose-response relationship. The incidence of side-effects was similar with both drugs. Gastrointestinal intolerance was more frequent and severe in the aspirin group, whereas rash and headache were noted more often in patients receiving oxaprozin.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1978

A systematic survey of the HLA B27 prevalence in inflammatory rheumatic diseases.

HLA B27 has been tested systematically in 246 patients attending a rheumatology clinic for chronic inflammatory arthritis or spondylitis. Patients were allocated to nine groups: typical ankylosing spondylitis, ankylosing spondylitis with moderate involvement without peripheral arthritis, ankylosing spondylitis with moderate involvement and with peripheral arthritis, juvenile chronic arthritis, Reiter's syndrome, Yersinia arthritis, arthropathies of inflammatory bowel disease, psoriatic arthritis, seronegative and seropositive rheumatoid arthritis. Except for seropositive rheumatoid arthritis, a significant association with HLA B27 antigen was found in all groups. In the seronegative rheumatoid arthritis group HLA B27 was present in 40% of the cases in contrast to 5.6% of the seropositive rheumatoid arthritis cases. These data confirm that a wide range of the so called "seronegative arthropathies" are associated with HLA B27 and suggest that sex and HLA B27 antigen are important factors in the manifestation of rheumatic disease. Women had less severe spondylitic changes but more peripheral arthritis of the small joints. Ankylosing spondylitis in its various forms had a comparable sex distribution despite relatively mild disease in females. The mean age of onset in the HLA B27 associated diseases was found to be significantly lower than in the seropositive rheumatoid arthritis group.

Arthritis, Juvenile↗
PubMed1977

Comparison of technetium uptake in small joints with other indices of inflammation in rheumatoid arthritis.

The uptake of 99mTc in the small joints of the hand has been compared to various other mesures of inflammation in 22 patients with rheumatoid arthritis. The 99mTc uptake in the finger joints can reflect both disease activity at a given time and change in activity over a period of time. The place of Tc uptake amongst other measures of inflammation, from the point of view of the 'relative efficiency' of the assessment method, is rather inferior. In evaluating the effect of antiphlogistic drugs on local inflammation, techneticum uptake may, however, prove more discriminating than grip-strength or the number of painful joints, since the latter measures depend largely on the degree of destruction.

Adult↗
PubMed1977

Arthritis in Flemish paintings (1400-1700).

A close examination of the hands of people depicted in paintings of the Flemish school showed that in five paintings there were figures with hand lesions resembling those of rhematoid arthritis. Although none of the deformities or swellings are indisputable examples of rheumatoid arthritis, they do at least suggest that the painters must have been confronted with rheumatoid-like lesions in their models. In two other paintings there were signs of rheumatic fever and of temporal arteritis. No arthritic lesions were found in the works of painters of the Italian Renaissance, probably because they are less detailed. The finding of rheumatoid deformities in the Flemish paintings does, however, question the general belief that rheumatoid arthritis is a condition that has arisen relatively recently.

Arthritis, Rheumatoid↗
PubMed1976

Relevance of hydroxyproline excretion to bone metastasis in breast cancer.

In 181 consecutive patients with breast cancer, urinary hydroxyproline excretion has been critically evaluated in conjunction with clinical, biochemical, radiological and scintigraphic parameters. The urinary hydroxyproline/creatinine ratio is a sensitive index of the presence of bone metastases. Urinary hydroxyproline excretion is a reliable method of selecting those patients whose elevated serum alkaline phosphatase is secondary to bone disease rather than liver idsease. The estimation of hydroxyproline excretion furthermore gives information on the activity of bone metastasis, and its response to treatment, which cannot be given by radiological or scintigraphic methods. It is doubtful whether urinary hydroxyproline estimation will help to detect bone metastases before they are apparent on scintigrams. When the bone scan is doubtful, as often occurs in older subjects, hydroxyproline excretion has been found to be helpful in classifying the patient. When scintigraphy is not available, an elevation of hydroxyproline excretion, together with an elevation of Ca/cr ratio or alkaline phosphatase activity, may pre-date by several months the radiological demonstration of osseous metastases.

Adult↗
PubMed1976

Quantitative radiology: radiogrammetry of cortical bone.

Based on personal experience and data in the literature, an overview is given of radiogrammetry of cortical bone of the second metacarpal. There is a within- and between-observer error which amounts respectively to 1.2 and 1.5% for the outer diameter and 4.8 and 6.4% for the inner diameter. The systematic + or-- trend between observers indicates that one observer working according to certain defined rules obtains the most reliable results. There is a large variability in amount of bone within one age and sex group which is partly due to skeletal size differences, are insufficient since skeletal size differences still exist. The variability is reduced when the data are divided into strata of skeletal size. Since cortical area shows the best correlation with outer diameter within each age group and since cortical area represents best the ash content of the bones the values of this index are most suited to be grouped according to outer diameter. In differentiating pathological from physiological bone loss this procedure is an improvement on the previously published indices of amount of bone. When comparing different populations this method has advantages since skeletal size differences are eliminated. Comparing seven populations it was found that populations living in the United States of America have more bone for a given skeletal size than populations in Europe or Nigeria. Bone loss with age is a general phenomenon but differences in rate of loss are observed between the sexes and between ethnic different populations. The decrease of bone mass is faster after the age of 50 years in woman than in men. Blacks living in the United States loose less bone with age than whites. Radiogrammetry of cortical bone in groups gives useful information on bond remodelling during ageing and in pathological conditions. At an individual level, however, it is difficult to evaluate changes on a short term basis with radiogrammetry. Radiogrammetry of cortical bone is a simple and reproducible method which measures bone mass indirectly. Changes in cortical width show a high degree of correlation with the changes in mass of cortical bones but trabecular bone is not measured. This is a serious handicap, since most of the metabolic diseases of the skeleton affect trabecular bone to a greater extent than cortical. Nevertheless the measurement of cortical thickness certainly has added to the knowledge of changes in bone mass in ageing and in disease.

Adolescent↗
PubMed1976

Arthritis and heart lesions. A study of 25 cases with pericarditis or valvular lesions associated to inflammatory joint disease.

Clinical and laboratory data of 25 patients with inflammatory joint disease and pericarditis or valvular heart disease are reviewed. The patients were divided in two groups: 11 presented pericarditis and 14 valvular heart disease. The patients studied presented a spectrum of diseases ranging from classical sero-positive rheumatoid arthritis to ankylosing spondylitis. Acute rheumatic fever was in no case the actual joint disease. In contrast to the patients with valvular heart disease nearly all patients with pericarditis were rheumatoid arthritis factor positive and signs of a generalized systemic disease with vasculitis were also more frequent. In the pericarditis group there was no sex difference in contrast to the valvular group where females were more often affected. The heart lesions were usually detected late in the course of the chronic joint disease. Valvular heart disease occurs not only in ankylosing spondylitis but also in rheumatoid arthritis, usually the sero-negative type. In the light of a survey of the literature, the pertinent findings are discussed.

Adult↗
PubMed1976

[Acute polyarthritis in Yersinia enterocolitica infection. 4 cases in Belgium].

Four cases in acute polyarthritis observed in Belgium, secondary to infection with Yersinia enterocolitica are reported. Apart from in Finland, where the frequency of yersinian rheumatism appears to be equal to that of Bouillaud's disease, these published cases are exceptional. This might appear surprising when it is realized that Yersinia is endemic in Western Europe and in other parts of the world and that alimentary manifestations are not rare and are now well known. This polyarthritis presents as an aspecific oligo-arthritis that is often preceded by acute enteritis and resolves itself spontaneously in several months. Determination of specific agglutinins is the basis of diagnosis. Twice the authors noted a temporary gonoreaction associated with an increase in the anti-Yersinia agglutinins. The few cases presented will help in the recognition of this new form of acute polyarthritis, which may be included among the infectious rheumatisms, and which is probably more frequent than it appears from reading the rheumatological literature.

Acute Disease↗