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J Debray

Publications and source records attributed to J Debray.

153 records · Page 9Linked to original sources
PubMedDate not supplied

[Very long survivals of chronic granulocytic leukemia (author's transl)].

Following busulfan induced bone marrow insufficiency, a patient witha chronic granulocytic leukemia (CGL) has had a survival lasting 18.5 years. During remission, chromosome studies on bone marrow have not shown Philadelphia chromosome (Ph 1). There was no correlation between this observation and initial pronostic factors from literature. Analysis of 14 cases (13 from literature) of prolonged survival showed that Ph 1 was absent in 4 cases when only 15% of CGL are initially Ph 1 negative. Therapeuticcaryoconversions were probable. Recently attempts have been made to eradicate the abnormal Ph 1 positive clone. Some hopeful results are reported.

Adult↗
PubMedDate not supplied

[Complications after perhexiline maleate and amiodarone chlorhydrate treatment in a same patient: hypoglycemia, polyneuritis and hyperthyroidism (author's transl)].

The authors report the case of a 65 year old man treated with amiodarone chlorhydrate since 4 years and perhexiline maleate since 15 months, admitted for constitutional symptoms with fever, neurologic troubles particularly polyneuritis and pronounced hypoglycemia. A diagnostic of hyperthyroidism was made and attributed to amiodarone. The hypoglycemia and the polyneuritis were related to perhexiline maleate as other signs presented by the patient. All the symptoms disappeared after discontinuation of the drugs. The complications secondary to maleate perhexiline administration are reviewed.

Aged↗
PubMedDate not supplied

[Extra skeletal Ewing's sarcoma. Report of two cases. Ultrastructural study of one case (author's transl)].

The authors report two cases of extra skeletal Ewing's sarcoma. The first case concerns a 26 years old woman presenting a tumor at the level of the sacrum area, locally recurrent, metastazing to the lungs and the lumbar column, despite of radiotherapy and chemotherapy and leading to death after a course of 18 months. The second one is that of a 30 years old man bearing a tumor of the shoulder area probably already metastazed to bones, rapidly recurrent and metastazing to the lungs and cause of death after 9 months in spite of intensive therapy. About these 2 observations a review of the literature of the cases of extra skeletal Ewing's sarcoma is done. Whatever nosologic discussion it seems that Ewing's sarcoma may present essentially as a tumor of soft tissues. An ultrastructural study has been performed in the second case. The findings are similar to those reported in Ewing's sarcoma.

Adult↗
PubMedDate not supplied

[Meningeal leukemia during acute promyelocytic leukemia (author's transl)].

The authors report the case of a meningeal leukemia occuring during the remission stage of an acute promyelocytic leukemia. The data from literature about the meningeal leukemia of acute granulocytic leukemias, the expected long survival of acute promyelocytic leukemias lead to think that this meningeal complication must be systematically prevented.

Adult↗