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Biomedical subjects

J De Boever

Publications and source records attributed to J De Boever.

At least 55 records · Page 3Linked to original sources
PubMed1980

Successful pregnancy in an abortion-prone woman: prostaglandin and hormone levels during implantation, gestation and lactation.

Serum progesterone, human chorionic gonadotropin, prostaglandin E2, F2 alpha and 13,14-dihydro-15-keto-PGF2 alpha and urinary immunoractive prostaglandins E2 and F2 alpha were measured throughout gestation in a woman who previously had experienced three abortions, an immature birth of a twin and a term single pregnancy. Prostaglandin-mediated symptoms such as uterine sensitivity and contractions, backache, spotting, vomiting and diarrhea were carefully registered and have been correlated with the variations in prostaglandin levels. The effect of therapy with a prostaglandin synthetase inhibitor and a beta-adrenergic drug on prostaglandin levels was also studied. The rise of prostaglandin E2 level observed during implantation is discussed.

Abortion, Spontaneous↗
PubMed1979

Replenishment and nuclear retention of oestradiol-17 beta receptors in rat uteri during postnatal development.

1. Uteri of 6--10-day-old rats do not show a late growth response to oestrogen (increase in rate of DNA synthesis and cell division) exhibited by fully competent (20 days or older) uteri. We posed the question whether the lack of the late growth response is due to an inability to replenish the cytoplasmic pool of oestrogen receptors or to curtailed retention of oestrogen binding in the nucleus. Uterine nuclear and cytoplasmic receptors were measured by a [3H]oestradiol-17 beta exchange assay, at 1, 3, 6, 14 and 24 h after oestrogen injection. 2. The replenishment of cytoplasmic oestrogen receptors showed a similar pattern in the uteri of 6 and 10-day-old (partially responsive) and in 20-day-old (fully responsive) rats. 3. Oestrogen was retained longer in uterine nuclei obtained from 5 and 10-day-old rats than in uterine nuclei of 20 and 25-day-old rats. 4. Oestrogen receptors resistant to 0.4 M KCl extraction (residual receptors) were found in uterine nuclei of 6 and 25-day-old rats after oestrogen injection at all the times tested. The concentration of these residual receptors during the late period (6--24 h after injection) was not significantly different in uterine nuclei of 6-day-old and 25-day-old rats. 5. We conclude that neither lack of oestrogen receptor replenishment nor curtailed retention of oestrogen binding in the nucleus is the factor which limits the complete responsiveness to oestrogen in uteri of rats during postnatal development.

Aging↗