Biomedical subjects
J Day
Publications and source records attributed to J Day.
A statistical evaluation of baseline and follow-up carcinoembryonic antigen in patients with resectable colorectal carcinoma.
A long-term CEA follow-up was evaluated statistically for a series of 74 patients with primary colorectal carcinoma who underwent resections for cure. Thirty-three recurrences and 29 deaths were reported among this population after a median follow-up interval of 55 months. Preoperative CEA levels correlated with the Dukes' classification. However, the preoperative level adds significant information to Dukes' classification in the prediction of recurrence. Postoperative CEA assays taken later in the clinical evaluation process carry the most prognostic information for subsequent recurrence. Using matched-pairs techniques, the authors noted that CEA often rose in anticipation of recurrence, sometimes as early as one year before recurrence. The following four follow-up CEA events were evaluated: 1) three consecutive rising CEA's 2) CEA rises 5.0 ng/ml; 3) CEA exceeds 5.0 ng/ml; 4) CEA exceeds 5.0 ng/ml two consecutive times. The follow-up CEA events examined were characterized by false positive rates ranging from 17% to 66% and true positive rates ranging from 43% to 56% in the prediction of recurrence. From follow-up CEA evaluations, further clinical investigation appeared most warranted when CEA exceeds 5.0 ng/ml at two consecutive follow-up evaluations, but the chances of finding any subsequent recurrent disease was near 50%. Among patients experiencing recurrences, although forewarned by CEA elevations, there was no subsequent time when patients were most likely to have recurrence of disease.
Establishment and characterization of a cell line (SS78) from a human renal cell carcinoma.
A new cell line, SS78, was established from a primary renal cell carcinoma of a Caucasian male. The tissue was dispersed with collagenase, and viable cells were separated by flotation on a Ficoll-Hypaque gradient. In culture, the SS78 cells retained a distinct epithelial morphology, and no fibroblast like cells were seen. The cultured cells were aneuploid with a modal chromosome number of 80 and had several marker chromosomes. Inoculation of the cultured cells into athymic nude mice caused tumors at the sites of inoculation.
Hemispheric differences in semantic processing: category matching is not the same as category membership.
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Blood-pressure in urban and tribal Africa.
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Laser Raman spectroscopic study of specifically deuterated phospholipid bilayers.
Raman spectra of 1,2-dimyristoyl-sn-glycero-3-phosphocholines specifically deuterated in the 2 chain at one of positions 3, 4, 6, 10, 12, and 14 have been obtained as a function of temperature. The frequencies of the CD2 vibrational stretching modes depend on the position of the labeled CD2 group, being maximum at position 3 of the acyl chain and then decreasing until they become constant beyond position 6. This frequency dependence is interpreted in terms of the inductive effect of the charge distribution of the acyl chain carboxyl group. In both gel and liquid-crystal phases, the Raman line widths depend on the position of the CD2 group, being minimum at position 6 and increasing toward both ends of the hydrocarbon chain. The width of the CD stretching bands abruptly increases at the phase transition temperature. The magnitude of the increase depends upon the position of the label, increasing almost linearly up to position 10 and then decreasing for positions 12 and 14. The spectra for the CD2 group at position at position 3 and the terminal CD3 group are almost the same in both phases. These results are interpreted in terms of the effects of hydrocarbon chain organization on the vibrational modes.
High-density-lipoprotein cholesterol in the Maasai of East Africa: a cautionary note.
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Visual half-field word recognition as a function of syntactic class and imageability.
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Danazol and the premenstrual syndrome.
Danazol as a powerful antigonadotrophin is a logical mode of treatment for patients with premenstrual symptoms. Its preliminary use in a dose 200-800 mg daily is reported. Two groups of patients were treated and of 12 patients with severe symptoms (Group I) six benefited from treatment. The second group (Group II) presenting as fresh cases were given 400 mg daily as the first or second choice of treatment. This group had a high drop out rate and any benefit from treatment was marred by the side effects. Danazol will continue to be used where the symptoms are resistant to other treatment, especially when breast tenderness is predominant. The dose should be the minimum required for relief of symptoms.
Right-hemisphere language processing in normal right-handers.
Three experiments were conducted to investigate the verbal performance of the right cerebral hemisphere in right-handed individuals with normal intact brains. A manual reaction time (RT) measure was used to assess the relative efficiency of lateral stimulus-response pathways (e.g., left visual field-right hemisphere-left hand) in processing linguistic information. Experiment 1 showed that the right and left hemispheres were equally efficient at recognizing concrete object nouns in a lexical decision task. The RT data also suggested that abstract nouns may be recognized only by the left hemisphere. Experiments 2 and 3 demonstrated the right hemisphere's ability to detect semantic relationships between concrete nouns and their superordinate categories. The findings were discussed in terms of their consistency with data from split-brain research and their implications for models of the functional organization of language skills in the normal brain. It was proposed that the right hemisphere in the intact brain can play a functional role in processing language.
Obstetrical and gynecological survey betamethazone induction of labour.
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Arbovirus infections in Sarawak: the role of the domestic pig.
The possible role of pigs as arbovirus maintenance hosts and their importance as amplifier hosts was studied. Blood samples from 464 pigs of all ages collected in 1962 and 1964 were tested against 10 arboviruses. Antibodies to Japanese encephalitis and Getah viruses were particularly prevalent and their calculated monthly infection rates were 19-5% and 13-3% respectively. In 1969, 447 pigs were bled monthly throughout the year and the infection rates for Japanese encephalitis virus were calculated in pigs during the first year of life. Infection rates were not uniform throughout the year; the rate increases as the pig grew older and there was a marked seasonal increase in the infection rate in the period from November to January. This coincided with the seasonal major population peak of Culex tritaeniorhynchus following intense breeding of this mosquito prior to rice planting. It is suggested that, in Sarawak, the pig acts as a maintenance host of Japanese encephalitis in a cycle involving C. gelidus mosquitoes and also acts as an important amplifier host towards the end of the year in a cycle involving C. tritaeniorhynchus. It is further suggested that Getah virus is maintained in a similar cycle between C. tritaeniorhynchus and pigs.
The aetiology of hypocalcaemia in acute pancreatitis.
Plasma calcitonin, glucagon and parathyroid hormone were measured in patients with acute pancreatitis. Plasma calcitonin was not detectable in 6 specimens obtained from the hypocalcaemic patients. Plasma glucagon values were similar in patients with acute pancreatitis and control subjects and were unrelated to hypocalcaemia, which was not even induced by glucagon infusion. High or rising parathyroid hormone levels were noted in association with hypo-and normocalcaemia, suggesting that parathyroid hormone rises and maintains plasma calcium within normal limits. Plasma parathyroid hormone was, however, undetectable in 8 patients with prolonged hypocalcaemia. Deficiency of parathyroid hormone due to its destruction by proteolytic enzymes or because of parathyroid gland exhaustion is suggested as the major factor inducing persistent hypocalcaemia in acute pancreatitis. Administration of parathyroid hormone should, therefore, be considered in patients with acute pancreatitis when hypocalcaemia does not respond to intravenous calcium therapy.
Memory for orientation of forms as a function of their meaningfulness and complexity.
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Arbovirus infections in Sarawak, October 1968-February 1970: human serological studies in a land Dyak village.
449 human sera collected in a Land Dyak village were tested for antibodies to 11 arboviruses. Japanese encephalitis and dengue virus antibodies were particularly prevalent. The rates of infection with these viruses were estimated to be 5-2% per annum for Japanese encephalitis, 8-8% for dengue 1 and 4-3% for dengue 2. Chikungunya virus antibodies were quite common with an annual infection rate of the order of 5% per annum. Infections with other Group A and B and Bunyamwera group viruses were generally at a low level.
Large scale irrigation and arbovirus epidemiology, Kano Plain, Kenya. II. Preliminary serological survey.
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