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J Dausset

Publications and source records attributed to J Dausset.

472 records · Page 27Linked to original sources
PubMedDate not supplied

[Search for antilymphocytic antibodies in the serum of 67 children with juvenile chronic arthritis].

We sought the presence of lymphocytotoxic antibodies in the serum of 67 children with juvenile rheumatoid arthritis. We demonstrated in the serum of a large number of children (more than 50 %) antibodies reacting mainly with the cells not forming spontaneously rosettes with sheep red cells and/or all the mononuclear cells of the peripheral blood of normal subjects. These antibodies which are more active at 4 degrees C than at 20 degrees C are absorbable on red cells, and/or the platelet pool and present the characteristics of cold lymphocytotoxins. The presence of these antibodies was not correlated with either the clinical form of juvenile rheumatoid arthritis, nor with the duration of the course, nor with the treatment. Generally speaking, such antibodies are found during diseases where regulation of the immune response is modified.

Adolescent↗
PubMedDate not supplied

[HL-A system in psoriasis; study of 31 families (author's transl)].

31 families with at least two psoriatic members, including sometimes three generations (4 families) have been studied looking for HL-A markers. They include 80 affected (45 females, 35 males) and 75 healthy persons. BW 17 has been found present in 58 p. 100 of the unrelated patients, versus 7 p. 100 only in the normal population (p less than 10-9). Relative risk (R.R.) for the people bearing BW 17 is 38.34. Increase of B 13 is slight and non significant. BW 16, BW 37, BW 27 are within normal range. B 12 (R.R. :0.36) seems to have a protecting effect. B 8, B 14 are also decreased. Study of way of genetic transmission favours existence of a dominant gene of susceptibility frequently associated with BW 17 and particularly with haplotype A 1, BW 17. But other genetic or environmental factors may also play a role.

Adolescent↗