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Biomedical subjects

J Dausset

Publications and source records attributed to J Dausset.

At least 271 records · Page 15Linked to original sources
PubMed1976

[The Atri system. Immunogenetic lymphocytic system associated with ABO and ABH secretory systems].

The antigen Atri can be detected on the lymphocytes of 5.19% of ABH Secretor A individuals. The Atri substance is present in the plasma of the same individuals and can be fixed on group O erythrocytes. It is also found in the saliva of 30/32 A individuals not secreting substance A. Its existence in the saliva of A Secretor individuals, however, cannot be proved due to the presence of both the A and Atri antigens. The Atri substance is neutralized by the soluble substance A extracted from the gastric mucous of a pig. Yet the A and Atri antigens can be shown to be distinct on lymphocytes by redistribution of the corresponding sites and blocking of the A sites by an immune anti-A. On a genetic level, the Atri specificity might belong to a lymphocyte system comprising three alleles: Atri, RB and W100. These three specificities have the common characteristic of being expressed on a certain percentage of the lymphocytes of group A individuals. This system, provisionally named Atri, is functionally associated with the ABO system and secretor system. Nevertheless, the fact that in several families the Atri antigen is not expressed by the parents shows that its expression on lymphocytes requires the intervention of at least one gene in addition to the A and Se genes.

ABO Blood-Group System↗
PubMed1976

A lymphocyte immunogenetic system, Atri, associated with the ABO blood group and the ABH secretor system.

The antigen Atri can be detected on the lymphocytes of 5.19% of A, ABH secretor individuals. The Atri substance is present in the plasma of the same individuals and can be fixed on group O erythrocytes. It is also found in the saliva of 30 out of 32 A non-secretor individuals. Its existence in the saliva of A secretor individuals, however, cannot be proved due to the presence of both the A and Atri antigens. The A AND Atri antigens have been shown to be distinct on lymphocytes by capping and by blocking of the A sites. The fact that in several families the Atri antigen is not expressed by the parents shows that its expression on lymphocytes requires the intervention of at least one gene in addition to ABO and Se.

ABO Blood-Group System↗
PubMed1976

A "natural" anti-HLA-A2 antibody reacting with homozygous cells.

In the serum of a young normal male, never transfused, a cold cytotoxic IgM antibody was found reacting exclusively with A2 homozygous cells on a French panel, as shown by population and family studies. This antibody needs about two to five times more lymphocytes or platelets to be absorbed than an immune anti-A2 of the same titre. The antigen recognized by this antibody seems to be covered by the same molecule as HLA-A2, according to redistribution experiments.

Adult↗
PubMed1975

[Research of an association between HL-A antigens and systemic scleroderma].

49 unrelated subjects suffering from systemic scleroderma were typed for 28 HL-A antigens, without any particular significant association of an antigen with the disease or one of its manifestations being noted. In addition, 13 patients from the same family were genotyped for HL-A. Transmission of the disease through 4 generations does not seem to be linked to a particular haplotype and no pair of sibling HL-A identical patients were seen in the same generation. By contrast, two pairs of sibling patients were HL-A different. Nevertheless, other cases, and in particular familial, will be necessary before an association between the genes of susceptibility to S.S. and a gene in the chromosomal HL-A region may be definitely eliminated.

Adult↗
PubMed1975

[Treatment of bone marrow aplasia by allogenic bone marrow grafts].

Three patients with severe aplastic anemia were treated by bone marrow transplantation using the method described by Santos and Thomas. Two of the patients, both successfully grafted have survived for more than 5 and 6 months respectively. Chimerism was proved by cytogenetic analysis and erythrocytic phenotypes. In one case, a severe graft versus host reaction was cured with ATG and prednisone. Graft rejection in the third case was related to the immunisation caused by many previous transfusions. Although bone marrow grafting is limited by the necessity of using a matched sibling as donor, its success this far is very encouraging and represents a new hope for the treatment of aplastic anemia.

Adolescent↗