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Biomedical subjects

J Danko

Publications and source records attributed to J Danko.

At least 55 records · Page 3Linked to original sources
PubMed1984

Homeostasis of fetal lactate metabolism in late pregnancy and the changes during labor and delivery.

Electrochemical enzymatic measurements of whole blood lactate concentrations were performed in 110 deliveries. In the majority of uncomplicated vaginal deliveries and of elective cesarean sections cord blood levels were higher than maternal concentrations and, as indicated by a positive arterio-venous difference for the cord vessels, lactate is originating in the fetus. In cases with clinical signs of fetal distress production of lactate due to anaerobic glycolysis is markedly increased. Differently from some other studies with uncomplicated vaginal deliveries, maternal lactate concentrations remained below fetal levels in almost 80%, which is explained by a conservative management of the second stage of labor with active pushing being restricted to the final phase of expulsion. The question whether also in late pregnancy the undisturbed human fetus in utero produces lactate or makes use of placental lactate as a substrate for its oxidative metabolism - as has been shown for some animal species - cannot be answered from the presently available evidence.

Energy Metabolism↗
PubMed1979

Combined regional chemotherapy and radiation therapy in the treatment of epidermoid carcinoma in the oro-facial region.

Followed treatment of oro-facial epidermoid carcinoma by combined chemo- and radiation therapy with eventual surgical intervention. Cytostatic drugs were applied intraarterially. After a monocytostatic treatment trial with Methotrexat (MTX), a combined cytostatic program was worked out utilizing two cytostatic drugs, viz. MTX and Bleomycin (BLM) in a cyclic alternation. Usefulness of chemotherapy and its inclusion into the treatment of epidermoid carcinoma in the oro-facial region was found justified principally in the case of combined therapy. However, the selected intraarterial mode of cytostatic administration is attended by certain drawbacks, mainly of a technical nature and is not suitable for routine application. For this reason, the authors have abandoned the i. a. mode of cytostatic administration in epidermoid oro-facial carcinoma and have adopted systemic application and this in combination with radiation, eventually surgical therapy with the utilization of chemotherapy.

Bleomycin↗