Search PubMed⌕ Search

Biomedical subjects

J Dangoumau

Publications and source records attributed to J Dangoumau.

48 records · Page 3Linked to original sources

[Effect of temperature on the kinetics of propranolol, theophylline, phenytoin and digoxin in rats (author's transl)].

1. The effect of chronic hyperthermia (35 degree C for 1 month) on the kinetics of propranolol, theophylline, diphenylhydantoin and digoxin was studied in groups of male Wistar rats. 2. Each compound was administered by intravenous injection, dosage being 2 mg/kg for propranolol, 3 mg/kg for theophylline, 10 mg/kg for phenytoin, and 0.01 mg/Kg for digoxin. 3. Total body clearance was diminished, mainly by an increase in the elimination half-life, for propranolol, theophylline, and digoxin. That of phenytoin remained unchanged. 4. Distribution volume increased slightly with propranolol, theophylline, digoxin.

Animals↗