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Biomedical subjects

J D Woodruff

Publications and source records attributed to J D Woodruff.

At least 73 records · Page 4Linked to original sources
PubMed1983

Microinvasive cervical cancer after five negative Papanicolaou smears.

In view of the controversy regarding the appropriate frequency for cytologic screening, a 28-year-old woman who developed microinvasive carcinoma of the cervix less than one year after her fifth negative Papanicolaou smear is described. The lesion was found not high in the endocervical canal, but at the squamocolumnar junction well out on the portio of the cervix. This case documents that the risk of less frequent screening is not zero.

Adult↗
PubMed1982

Leiomyosarcoma of the uterus.

A series of 43 cases of uterine leiomyosarcoma was reviewed. Forty-one of the 43 patients were followed up 2 or more years. The overall 5-year survival was 73%. Favorable prognostic features included the premenopausal status of the patient, the confinement of the tumor within a myoma, the low mitotic count (less than four mitotic figures in any one high-power field or less than four mitotic figures per 10 high-power fields), the absence of necrosis, and the presence of hyalinization in the adjacent tissue suggesting confinement. Special cases such as those in which only myomectomy was performed and those receiving adjunctive chemotherapy are discussed. The differential in survival between patients with primary myosarcoma and those with lesions arising in a leiomyoma is stressed.

Adult↗
PubMed1982

Mixed Mullerian tumors of the uterus: clinical and pathologic correlations.

The 10-year experience at The Johns Hopkins Hospital with 61 cases of mixed Mullerian tumors were reviewed. The patients had a mean age of 63.7 years and the similar constitutional factors of diabetes mellitus, hypertension and nulliparity of endometrial adenocarcinoma. Only one patient had estrogen exposure. Eighteen percent had had prior exposure to pelvic radiation. The life table survival of the 61 patients was 41.1% at 5 years. The 2-year life table survival was 76% for disease confined to the uterus and 16.5% for extrauterine disease. There was no difference in survival between homologous and heterologous tumors. The surgical staging and the autopsies reviewed documented widely disseminated disease even when the tumor appeared to be confined to the uterus. It thus appears essential in order to improve survival these patients require aggressive staging and consideration of systemic adjuvant chemotherapy.

Adult↗
PubMed1982

Uterine stromatosis: a report of 33 cases.

Uterine stromatosis is an uncommon intramyometrial lesion. The present study reviews the clinicopathologic aspects of 33 cases, 9 of which were treated at The Johns Hopkins Hospital, whereas 24 were referred to the gynecologic pathology laboratory. In the series it was noted that progesterone therapy was able to control the spread of the condition and to cause regression of extrauterine disease for periods up to 9 years. Criteria for the diagnosis of malignancy in stromatosis are discussed.

Adult↗
PubMed1982

Verrucous carcinoma of the vulva: study of 24 cases.

The clinicopathologic features of 24 cases of vulvar verrucous carcinoma were reviewed. Based on the absence of lymph node metastasis in 27 patients who underwent radical vulvectomy with lymph node dissection (10 in previous series, 17 in present series), a conservative approach consisting of wide local excision is suggested. Radiotherapy did not aid in prolonging survival.

Adult↗
PubMed1981

Atypical epithelial proliferations in the fallopian tube.

Between the years 1950 and 1979, thirty-nine diagnoses of "atypical epithelial proliferation in the fallopian tube" were made in the Gynecologic Pathology Laboratory at The Johns Hopkins Hospital. In this discussion, the criteria for histopathologic diagnosis of such alterations are described. This series demonstrated an association of the tubal proliferations with malignancy in the upper genital canal and exogenous or endogenous estrogen stimulation. However, progression of these proliferative conditions to invasive tubal cancer was not documented.

Epithelium↗
PubMed1981

Leiomyomatosis in pelvic lymph nodes.

A decidual reaction may occur in the pelvic lymph nodes during normal pregnancy. This reaction may be replaced by the same type of benign metaplastic reaction that gives rise to leiomyomatosis peritonealis disseminata. The occurrence of this apparent smooth muscle in the pelvic lymph nodes may result in an erroneous diagnosis of metastatic leiomyosarcoma, or of benign metastasizing leiomyoma.

Adult↗
PubMed1981

Dysgerminoma: a review of 158 cases from the Emil Novak Ovarian Tumor Registry.

One hundred and fifty-eight dysgerminomas from the Emil Novak Ovarian Tumor Registry and the Gynecologic Pathology Laboratory of The Johns Hopkins Hospital were reviewed. Five-year follow-up was available for 82% and 10-year follow-up was available for 65%, with survival rates of 83% and 74% for pure tumors, respectively. Survival was related to stage of disease and presence of other germ cell elements. Patients treated by unilateral adnexectomy alone for stage IA pure dysgerminoma had a 95% 5-year survival. Survival of these patients was not affected by tumor size.

Adolescent↗