Biomedical subjects
Publications and source records attributed to J D White.
Teratomas of the tongue are extremely rare neoplasms, with only five reported cases in the literature. We report an additional case here and review the literature on this rare entity.
Random source dogs were anesthetized and cooled by immersion in ice water to a stable core temperature of 25 degrees C and subsequently rewarmed with either normal saline peritoneal lavage (43 degrees C, 175 ml/kg/h) or warmed humidified inhalation (43 degrees C, 450 ml/kg/min ventilation). The time required for core rewarming to 30 degrees C was 192 +/- 61 minutes for lavage and 331 +/- 96 minutes for inhalation therapy (P less than 0.03). These data suggest that peritoneal lavage is superior to inhalation therapy for core rewarming of rapidly induced immersion hypothermia.
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The antiviral drug ribavirin (1, beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) produced significant hematologic effects when administered to rhesus monkeys by intramuscular injection over 10 days in doses of 30 or 100 mg/kg/day. The monkeys developed dose-related progressive anemia and thrombocytosis associated with marrow erythroid hypoplasia and megakaryocyte hyperplasia. In addition, bone marrow examination revealed phagocytosis of erythroid elements by histiocytes; vacuolization of erythroid precursors, and to a lesser extent precursors of other cell types; and occasional erythroid precursors with megaloblastoid appearance. The alterations were transient and disappeared on discontinuation of the drug.
A growing body of literature suggests that oxytocin (OXY) and arginine-vasopressin (AVP), in addition to their neuroendocrine roles, may serve as neuromodulators within the central nervous system of mammals. The present study investigated the biosynthesis of OXY, AVP, and their associated neurophysins in the paraventricular nucleus of the hypothalamus (PVN) and the transport of these peptides to the neural lobe and the nucleus of the solitary tract (NTS) in the brainstem of the rat. Rats were cannulated bilaterally in the PVN, and 24 hr later a 2-hr pulse of [35S]cysteine was administered using an Alzet minipump delivery system. After a 10-hr chase period, the neural lobe was removed and the PVN and NTS were punched. Tissue homogenates were adsorbed to and eluted from octadecyl-silica cartridges and analyzed by linear high performance liquid chromatography (HPLC) gradient elution, chemical and enzymatic modification, and exponential gradient HPLC elution followed by linear HPLC gradient analysis using an ion-pairing buffer system. This rigorous approach has allowed us to identify 35S-labeled material which co-purifies with OXY and AVP from the PVN, neural lobe, and NTS samples. Specific transport of the nonapeptides to the NTS was demonstrated when a unilateral transection of the hypothalamic fibers resulted in a unilateral depletion of the radiolabeled peptides from the NTS samples. Additionally, each of the neurophysins was purified from the neural lobe and NTS samples after linear HPLC gradient analysis, ion-pairing buffer linear gradient analysis, then tryptic digestion followed by exponential gradient HPLC analysis.(ABSTRACT TRUNCATED AT 250 WORDS)
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Anesthetized random source dogs were cooled by ice water immersion to a stable core temperature of 25 degrees C and subsequently rewarmed with warm humidified inhalation (43 degrees C, 450 cc of min ventilation X kg-1) or radio-frequency induction hyperthermia (4-6 watts X kg-1). The mean time required for core rewarming to 30 degrees C was 280 +/- 114 min for ventilation and 58 +/- 13 min for radio wave therapy (p less than 0.001). There was no evidence of tissue damage with either modality. These data suggest radio wave heating is superior to warm humidified inhalation therapy for core rewarming of rapidly induced immersion hypothermia.
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A total of 139 patients had transthoracic pacemakers introduced via a subxiphoid approach for asystole during advanced CPR in the emergency department of a large urban teaching hospital over a calendar year. Two groups were examined retrospectively, A) 34 patients who presented asystolic, and B) 99 patients who presented with ventricular fibrillation that became asystole. Age, sex, and etiologies for cardiac arrest were similar in both groups; there were no survivors. The mean duration of asystole before pacemaker insertion was 4 min (group A) to 7 min (group B). Temporary electrical capture was obtained in six patients from group B, but electrical-mechanical association could not be achieved in any of these patients.
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A study was conducted to assess the effects of personality schemata on attentional allocation, impressions, and memory among observers of a complex social interaction. Subjects were first primed with schematic descriptions of an actor, and then they listened to an audiotape in which that actor and another participated in several separate conversations, with the primed actor either in the foreground or in the background. Other subjects could throw a switch to shift either actors' conversations into the foreground. As predicted, subjects in this last group shifted their attention away from the primed actor after determining that his behavior did not violate the schema they had been given and shifted their attention back when the primed actor acted in a schema-inconsistent manner. Analyses of all three attentional conditions revealed that the less attention subjects were able to pay to the primed actor, the more they relied on their schemata in making impression judgments, the more confident they were in the occurrence of schema-consistent "false alarm" behaviors, and the less confident they were in the occurrence of schema-inconsistent and schema-irrelevant behaviors. These results are discussed in terms of subject strategies in dealing with information overload when processing complex stimuli.
Conditions for the preparation, purification, and maintenance of karyoplasts which could regenerate to reform whole viable cells were defined. Results of biochemical analyses of such karyoplasts at various times during regeneration indicated that a reproducible biosynthetic program was followed. Thus, an examination of the polypeptides made during regeneration by two-dimensional gel electrophoresis showed that the pattern of radiolabeled polypeptides synthesized at each time studied was specific and was significantly different from that observed at other times during regeneration. Polypeptides associated with three major cellular fractions--nuclear, cytoskeletal-microtrabecular, and soluble--were among the most dramatically regulated molecules. Other polypeptides, such as the major components of microfilaments and intermediate filaments, were synthesized at relatively constant rates and were assembled into structures throughout regeneration. Likewise, microtubules appeared to be reformed throughout regeneration, even in the absence of identifiable centriole-associated organizing centers. Finally, analysis of DNA synthesis by autoradiography showed that, even when prepared from whole cells synchronized at the G1/S interface, karyoplasts could not begin making DNA until they had regenerated an almost complete complement of cytoplasm.
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Spherical to oval particles with a unit membrane and subunit surface structure were demonstrated by negative-contrast staining of supernatant fluids of A-549 cell cultures infected with strain 76-118 of Hantaan virus. The particles had an average diameter of about 95 nm, with a range of 80 to 110 nm. Similar particles were isolated by buoyant density fractionation in sucrose gradients. In four separate experiments, infectivity cosedimented with 95 nm particles at buoyant densities from 1.15 to 1.18 g/ml. Immunoaggregation of the virions was specifically produced by antisera obtained after Hantaan virus infection of man and rabbit. The known physicochemical and morphological properties of these particles are compatible with those generally reported for the Bunyaviridae family of viruses.