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Biomedical subjects

J D Vince

Publications and source records attributed to J D Vince.

At least 19 recordsLinked to original sources

Low birthweight at a Papua New Guinea highlands hospital.

A prospective case-control study involving 75 low birthweight (LBW) babies and 224 controls was carried out at the Mount Hagen General Hospital over a period of 7 months, from June to December 1997. Identified risk factors for LBW in this population included maternal age (age less than 22 years or over 35 years, p = 0.03), a birth interval of less than 2 years (p = 0.006), no antenatal booking (p = <0.005), low attendance at antenatal clinic (p = <0.005), fever during pregnancy (p = <0.005), PET (p = 0.05), APH (p = <0.015), and maternal smoking during pregnancy (p = 0.008). Other well-established risk factors for LBW, i.e. small stature, low body mass index (BMI), haemoglobin less than 8 g/dl, and low educational attainment, appeared to be more frequent in the mothers of the LBW babies than the controls but differences did not reach statistical significance. The results suggest the need for improved provision of, and efforts to increase the use of, antenatal and family planning services. The results also provide clear evidence of the deleterious effects of smoking during pregnancy in a developing country.

Adult↗

Ten-year experience with paediatric lymph node tuberculosis in Port Moresby.

This is a descriptive study of short-course chemotherapy in children with nodal tuberculosis at Port Moresby General Hospital (PMGH). Between 1 August 1989 and 31 December 1997 5248 children were started on TB treatment. In the retrospective study 427 children were treated for lymph node TB up to 31 December 1996. Of these, 207 definitely completed the treatment and 24 (11.6 per cent) of them were known to have relapsed up to the end of 1997. In the prospective study 179 children with lymph node TB were enrolled between 1 January 1997 and 31 December 1997. Of these, 97 definitely completed the treatment and 10 (10.6 per cent) were known to have relapsed during a follow-up period of between 1 and 2 years.

Adolescent↗

A retrospective review of paediatric lymph node tuberculosis in Port Moresby, Papua New Guinea.

The study aimed to examine the perception that the relapse rate following standard short-course chemotherapy in children with lymph node tuberculosis is greater than in similarly treated children with pulmonary tuberculosis (TB). The treatment records, clinical data and results of investigations of 427 children treated for lymph node TB between 1989 and 1996 were analysed. The results and role of investigations are discussed. The relapse rate was compared with that of 892 children treated for pulmonary TB during the same period. The documented relapse rate for lymph node TB was 2.8% compared with 0.6% in pulmonary TB. This highly significant difference led to a prospective study of outcome of lymph node TB treatment in Port Moresby.

Biopsy, Needle↗

Outcome of neonatal care in Port Moresby, Papua New Guinea: a 19-year review.

The effectiveness of changes in practice can only be determined by comparing outcome before and after their introduction. This report presents and discusses the neonatal statistics from Port Moresby General Hospital (PMGH) over the last 19 years and attempts to determine the effects of changes in practice introduced during the last year of the study period. Neonatal mortality rates have been very constant. However, the changes in practice--having all but the sickest babies nursed with their mothers and encouraging kangaroo care--together with strict adherence to breastfeeding policies, including the use of expressed breastmilk wherever possible, and the close involvement of the local breastfeeding support group in follow-up, appeared to have beneficial effects in reducing the length of stay and increasing the rate of weight gain in the very low birthweight babies.

Cause of Death↗

Kangaroo care in Port Moresby, Papua New Guinea.

Kangaroo care is a simple and highly practical method of care of the low birthweight newborn which has been shown in some studies to significantly improve survival. We describe the introduction of 'kangaroo care' to the special care nursery at Port Moresby General Hospital, discuss the problems encountered and attempt to assess its impact in a 1-year retrospective study, during which it was associated with a reduction in hypothermia and an increased rate of weight gain.

Humans↗

Langerhan cell granulomatosis with unusual FNAC findings.

An interesting case of a multifocal Langerhans cell granulomatosis in an 18-mo-old female child is described. The diagnosis was confirmed by fine-needle aspiration cytology. The unusual findings at the initial stage of the disease and its possible etiopathogenesis are discussed.

Biopsy, Needle↗

Anthropometrical antecedents of non-insulin dependent diabetes mellitus: an age and sex matched comparison study of anthropometric indices in schoolchildren from a high prevalence Port Moresby community.

Anthropometrical indices of 66 school children aged between 7 and 9 years from a community with a very high prevalence of non-insulin dependent diabetes mellitus (NIDDM) were compared with those of age and sex matched school children from two low prevalence communities. Two way analysis of variance indicated that case children of both sexes were significantly lighter (P < 0.001), shorter (P < 0.001) and had lower body mass indices (BMI) (P < 0.001) than their comparisons but had greater triceps skinfold thickness (TSFT) (P = 0.01). These differences may be a reflection of subtle changes in metabolism in children destined, without intervention, to develop NIDDM. Anthropometrical indices may therefore have a role to play in the prediction of future disease. Although not the prime objective of the study, an analysis of available birth weights indicated a lower mean birth weight for the cases than the controls (difference of means, 0.35 kg; 95% confidence intervals (CI95%). 0.13-0.57). This finding is consistent with the theory that impaired intrauterine growth may predispose to NIDDM.

Body Constitution↗

The management of asthma in children in Papua New Guinea.

In the last decade advances in knowledge of the aetiology and pathogenesis of asthma, and the availability of metered-dose inhalers and nebulisers, has led to a change in emphasis in both the preventive and curative aspects of the management of children with asthma. Metered-dose inhalers are available in Papua New Guinea, and can be used successfully, with spacing devices, even in children less than 2 years of age. Inhaled beta-sympathomimetics, now widely available and relatively inexpensive, may be all that is required for the majority of children with infrequent episodic asthma. For those with frequent episodic and chronic asthma, preventive therapy with inhaled steroids is available and should be given wherever practicable. In the management of acute severe asthma inhaled beta-sympathomimetics should be combined with a short course of oral or parenteral steroids (covered with isoniazid in areas where tuberculosis is prevalent). Whilst asthma classically presents with wheeze, medical personnel should be aware of its other presentations. It is possible, and should be the aim, to achieve a very high level of control for the majority of asthmatic children using currently available therapy.

Anti-Asthmatic Agents↗

Diarrhoea in children in Papua New Guinea.

National data for diarrhoeal disease in children can only be used as a very rough guide to morbidity and mortality, since they are based on incomplete reporting. Furthermore, when only one diagnosis per attendance, admission or cause of death is recorded, the true importance of diarrhoea as a cause of morbidity and mortality may be obscured. This may in part explain discrepancies between figures recorded in national and hospital statistics and those recorded in detailed studies of diarrhoeal admissions. While there appear to be quite marked differences in the relative importance of diarrhoea in different parts of the country, and while diarrhoeal disease is less of a scourge than in some other parts of the world, it is nevertheless a major cause of attendance at health facilities, the second or third most common cause of admission to many of the hospitals in the country, and a significant and often preventable cause of death. Limited studies of diarrhoeal aetiology indicate the major importance of rotavirus, Shigella and enteropathogenic and enterotoxigenic Escherichia coli. The control of diarrhoeal diseases in children is based not only on early and appropriate treatment, but also on preventive strategies. These include breastfeeding (which has saved the lives of many thousands of Papua New Guinean children and which is once again under threat), ensuring good host defence by good nutrition, immunization and early treatment of childhood illness, and ensuring satisfactory sanitation and hygiene. Increasing fluid intake to prevent dehydration remains the most important part of the early management of acute diarrhoeal disease. In the management of children with dehydration, UNICEF glucose-based oral rehydration therapy is widely available but not used as well as it should be. There are significant advantages in cereal-based oral rehydration solutions, and the use of such solutions, locally prepared, should be encouraged. Breastfeeding should be continued during episodes of diarrhoea, unless there is the specific contraindication of lactose intolerance. In all events the child's nutritional intake should be maintained and if possible increased during episodes of diarrhoea. There are specific indications for the use of antibiotics in the management of children with diarrhoea. They should not be used, and may be harmful, in the absence of these indications. Persistent diarrhoea--lasting more than 14 days--is associated with a high mortality and severe malnutrition. It is therefore important that children whose diarrhoea is prolonged for more than 7 days are managed appropriately, using the standard guidelines.

Anti-Bacterial Agents↗

Age-specific prevalence of hepatitis B surface antigenaemia in hospitalized children at Port Moresby, Papua New Guinea (a cross-sectional study with implications for the Hepatitis B Control Programme).

A cross-sectional analysis of the prevalence of hepatitis B surface antigenaemia in cord blood from 50 newborn babies and in blood from 415 children admitted to the children's ward of Port Moresby General Hospital indicates that perinatal vertical transmission is likely to be important and that there is a high rate of horizontal transmission in the 1st few years of life. Thirteen per cent of infants aged 3-5 months and 29-30% of those over 2 years of age were strongly positive for hepatitis B surface antigen. Open sores and poor hygiene are likely to play a significant role in the high level of horizontal transmission of hepatitis B virus (HBV) in our context. Our findings give support and urgency to the current active immunization policy against HBV, beginning as soon as possible after birth.

Child↗

Tourniquet injury in a Papuan snakebite victim.

We report a case of snake bite complicated by tourniquet induced ischaemic damage and rhabdomyolysis causing acute renal failure. The case highlights the dangers of tourniquet use and of sudden release. We outline measures which can be taken to minimize morbidity in such patients.

Acute Kidney Injury↗

Purulent meningitis in children: outcome using a standard management regimen with chloramphenicol.

We report a prospective study of 108 children aged from 2 weeks to 10 years with purulent meningitis admitted to the children's wards of Port Moresby General Hospital, 105 of whom were treated with a standard management regimen using chloramphenicol (given intramuscularly initially) as the only antibiotic. The case fatality rate of 16.7% and the apparently low morbidity rate were felt to be very satisfactory in a high risk population. The medical officers' compliance with the standard antibiotic regimen was good, but was disappointing for the use of anticonvulsants. The presence of convulsions before admission or at any time in the illness, coma on admission, and a history of illness of more than 3 days duration prior to admission were strongly associated with death. We believe phenobarbitone should be given prophylactically to children less than 2 years of age who have meningitis. Further improvements in outcome are likely to be achieved not by changes in antibiotic policy but by improving early diagnosis and basic supportive care, and by preventing convulsions.

Bacteria↗

Malaria in children in Papua New Guinea.

Malaria is a major problem in children in many parts of Papua New Guinea; it has a high mortality and, if observations from other countries are applicable, significant long-term morbidity. Standard treatment regimens are the backbone of management of malaria throughout the country, but these must continue to be reviewed and updated in the face of changing patterns of parasite drug sensitivity. Diagnosis of malaria will for practical purposes remain primarily clinical for the foreseeable future. There is a need for uniform reporting of malaria statistics using the established definitions of uncomplicated, treatment failure and severe malaria, in order to assess incidence and outcome throughout the country, and to compare malaria patterns and outcome in Papua New Guinea with those in other parts of the world. Congenital malaria should always be considered in a febrile or ill neonate. Awareness of the complications of severe malaria, particularly hypoglycaemia, needs to be increased. Methods for the diagnosis and facilities for treatment of hypoglycaemia should be widely available. The characteristics of those children most at risk from hypoglycaemia need elucidation, and the current standard management regimen for severe malaria needs to be assessed for its propensity both to cause and to prevent hypoglycaemia. It would be reasonable to incorporate phenobarbitone prophylaxis of convulsions into the standard management regimen for cerebral malaria.

Antimalarials↗

Hepatitis B surface and e antigen seropositivity in mothers and cord blood at Port Moresby General Hospital: implications for a control program.

Analysis of 100 unselected paired maternal and cord blood samples showed 11 mothers to be HBsAg positive and 6 of these to be also HBeAg positive. 5 cord blood samples were HBsAg positive and 3 were HBeAg positive. Assuming a protective efficacy rate of 75%, the present plasma-derived hepatitis B virus vaccine control program is likely to prevent the perinatal acquisition of the hepatitis B virus carrier state in 27 per 1000 children. The addition of immunoglobulin prophylaxis would be likely to reduce this by another 5 per 1000, but its use does not appear practicable at the present time.

Adult↗