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Biomedical subjects

J D Smith

Publications and source records attributed to J D Smith.

At least 325 records · Page 18Linked to original sources
PubMed1980

Evidence of Rickettsia prowazekii infections in the United States.

From January 1976 through January 1979 serum specimens from 1,575 individuals were received at the Center for Disease Control and tested for antibodies to rickettsiae. Of these, sera from eight persons gave serological results indicative of recent infections with epidemic typhus rickettsiae (Rickettsia prowazekii). Five of the persons were from Georgia, and one each was from Tennessee, Pennsylvania and Massachusetts. The illnesses occurred during the winter, chiefly in persons living in a rural environment. The clinical picture was compatible with louse-borne epidemic typhus. There was no apparent contact with human body or head lice, and no cases occurred in patient contacts, indicating that infection was not associated with the classic man-louse-man cycle of epidemic typhus. Two of the eight patients had contact with flying squirrels suggesting that they became infected from this known extrahuman reservoir of R. prowazekii.

Adolescent↗
PubMed1979

Low- and high-dose intravenous insulin therapy for diabetic ketoacidosis.

We compared low-dose, continuous insulin infusion with a conventional high-dose intravenous bolus method of insulin administration in 18 episodes of diabetic ketoacidosis. The average rate of reduction in serum glucose concentration was 9.5 +/- 3.8%/hr in the continuous infusion group and 10.7 +/- 4.7%/hr in the bolus group. Arterial blood pH was corrected to 7.35 by 9.9 +/- 2.6/hours in the continuous infusion group and by 10.4 +/- 3.2/hours in the bolus group. The above means are not significantly different between groups. By the time pH was corrected to 7.35, patients in the continuous infusion group had received 121 +/- 44 units of insulin, whereas those in the bolus group had received 326 +/- 152 units. The continuous low-dose insulin infusion method is as safe and efficacious as the conventional high-dose intravenous bolus method.

Blood Glucose↗
PubMed1979

The purification and characterization of ADP-glucose pyrophosphorylase A from developing maize seeds.

ADPglucose pyrophosphorylase A (ATP:alpha-D-glucose-1-phosphate adenylyltransferase, EC 2.7.7.27) from developing maize (Zea mays) endosperm was purified 129 fold to apparent homogeneity. The molecular weight estimated by gel filtration and by polyacrylamide gel electrophoresis was 375 000 and 400 000, respectively. The preparation gave a single protein band after SDS-polyacrylamide gel electrophoresis suggesting a monomer mol. wt. of 96 000. It was concluded that ADPglucose pyrophosphorylase A in maize endosperm is a tetramer of four similar molecular weight subunits. Values for the Km for glucose 1-phosphate and ATP were 3.8 . 10(-5) and 1.8 . 10(-4) M, respectively (using the homogeneous preparation).

Adenosine Diphosphate Glucose↗
PubMed1979

Phospholipids of the differentiating bacterium Caulobacter crescentus.

The phospholipid composition of the stalked and swarmer cell types of the differentiating, Gram-negative bacterium Caulobacter crescentus was determined. The phospholipid composition of the stalked cell type was 86.5% phosphatidylglycerol, 10.4% lysylphosphatidylglycerol, and 3.0% cardiolipin; that of the swarmer cell type was 84.1, 11.4, and 4.4% respectively. Phosphatidylethanolamine, which is a major phospholipid component of most Gram-negative bacteria, was totally absent.

Bacterial Physiological Phenomena↗
PubMed1979

Practice effects within a multiple-phase Bender administration.

Practice effects within a multiple-phase administration of the Bender Visual-motor Gestalt Test were investigated. The addition of a 5-sec. Flash phase prior to the standard presentation did not significantly influence performance on the standard presentation. Students who attempted both the Flash and standard administration prior to a recall phase remembered significantly more designs than students receiving only the standard administration prior to recall. Those skills possibly measured by the multiple phase Bender format are discussed and the need for research using the three-phase method is suggested.

Age Factors↗
PubMed1979

The dimension of adaptive behavior in mental retardation research: an analysis of recent practices.

The dimension of adaptive behavior has been accepted by many professionals as an important component of identification in mental retardation since the definitions of Heber (1961) and Grossman (1973). In order to investigate the impact of this more comprehensive concept of mental retardation on research practices, we analyzed the use of adaptive behavior in the selection and description of subjects. This investigation was based in research articles published in the Americal Journal of Mental Deficiency from 1974 through 1978. In a significant percentage of the articles reviewed, the researchers had not attended to adaptive behavior and used only measures of intellectual functioning for descriptive purposes. These results were discussed in light of the validity of research on mental retardation. Recommendations were included for future research practices.

Adaptation, Psychological↗
PubMed1978

Control of phosphonic acid and phosphonolipid synthesis in Tetrahymena.

The phosphonolipid content of the protozoan Tetrahymena pyriformis was increased by growing the organism on a medium containing increasing amounts of 2-aminoethylphosphonic acid. With levels of 0, 1, 5 and 10 mM 2-amino-ethylphosphonic acid, the phosphonolipid content was 23, 25, 31 and 37% of the total cellular phospholipids, respectively. This increase was accompanied by a reciprocal decrease in phosphatidylethanolamine. With 32Pi in the growth medium along with the 2-aminoethylphosphonic acid, the incorporation of the radioactivity into new molecules of 2-aminoethylphosphonic acid was almost totally inhibited, indicating a feedback control on phosphonic acid synthesis.

Animals↗
PubMed1978

Auricular and Periauricular surgery.

Various surgical procedures are described for common disorders on and about the ear. Photographs are presented to show how they are performed. Applicable surgical subtleties and precautions are discussed.

Ear, External↗
PubMed1978

Herpes simplex virus and human cytomegalovirus replication in WI-38 cells. III. Cytochemical localization of lysosomal enzymes in infected cells.

Cytochemical localization of the lysosomal enzymes acid phosphatase and arylsulfatase in cells infected by herpes simplex virus (HSV) or human cytomegalovirus (CMV) showed the following interactions between viruses and host cell lysosomes: (i) many enveloped progeny viruses were located within cytoplasmic vacuoles containing lysosomal enzyme activity; (ii) naked cytoplasmic capsids appeared to acquire an envelope by budding directly into lysosomes; and (iii) many of the cytoplasmic dense bodies that are characteristic of CMV-infected cells and are thought to represent noninfectious aggregates of CMV structural proteins (I. Sarov and I. Abady, Virology 66:464-473, 1975) also acquired a limiting membrane by budding into lysosomes. Autophagy of other cytoplasmic elements was not observed, suggesting that there is some specificity involved in the association of viral particles and CMV dense bodies with lysosomes. Despite the presence of potentially destructive hydrolases, there was little evidence of significant morphological damage to intralysosomal viruses, and high titers of infectious particles were released into the medium. It would therefore appear that significant levels of HSV and CMV infectivity normally persist even though many progeny particles are directly exposed to lysosomal enzymes.

Acid Phosphatase↗