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Biomedical subjects

J D Rose

Publications and source records attributed to J D Rose.

At least 91 records · Page 5Linked to original sources
PubMed1981

Shrinkage of the gastric antrum following gastroenterostomy.

Radiological and endoscopic shrinkage of the antrum of the stomach may occur in the elderly and following gastroenterostomy. We describe this in 18 subjects, of whom 17 had a gastroenterostomy with or without vagotomy. Shrinkage can appear within two years of operation and is usually associated with a well-functioning stoma. Reflux biliary gastritis occurred in almost all and in nine out of ten tested the acid secretion in response to pentagastrin was virtually nil. Dyspepsia and bile vomiting were frequent indications for endoscopy. No patient had jejunal ulceration. In the majority radiological interpretation was correct.

Adult↗
PubMed1980

Paraquat poisoning.

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Acute Kidney Injury↗
PubMed1979

Preparation and purification of L-(+/-)-5-formyl-5,6,7,8-tetrahydrofolic acid.

Reinvestigation of the conversion of folic acid to leucovorin [L-(+/-)-5-CHO-THF] led to improved methods for the synthesis of this drug, which is suitable for clinical use. Also, methods were developed for the chromatographic and nonchromatographic purification of less pure samples of L-(+/-)-5-CHO-THF.

Chromatography, Liquid↗
PubMed1977

Echophonocardiographic diagnosis of left ventricular pseudoaneurysm.

We report the presence of an unusual systolic murmur associated with a traumatic left ventricular pseudoaneurysm. Echophonocardiographic studies showed the murmur to begin at the first heart sound, but end well before the second heart sound. It seems likely that the murmur is caused by the systolic flow of blood from the left ventricle into the relatively noncompliant pseudoaneurysm. The echocardiographic scan of the left ventricle demonstrated a relatively echo-free space posterior to the left ventricular wall, supporting the diagnosis of pseudoaneurysm, which has confirmed with angiographic studies and at surgery. These findings indicate that a combination of noninvasive techniques is useful in establishing this diagnosis.

Adult↗
PubMed1976

Routine blood cultures from febrile outpatients. Use in detecting bacteremia.

Of 565 febrile patients examined in the emergency room of a metropolitan hospital, 210 had blood samples cultured (37.1%). Bacteremia was present in 9 of 86 patients who were admitted to the hospital but in only one of 124 patients who were not admitted (P less than .005). Thus, approximately 5% of febrile adult outpatients had bacteremia, and these patients were usually admitted before the results of the culture were known. Since positive cultures were found so infrequently in patients not admitted and were, therefore, of little value in guiding the treatment of these patients, we conclude that use of routine blood cultures to screen for bacteremia in unnecessary for febrile adult outpatients who are not admitted to the hospital.

Adult↗
PubMed1975

Response properties and anatomical organization of pontine and medullary units responsive to vaginal stimulation in the cat.

The response properties and anatomical organization in the brain stem of 234 pontine and 60 medullary genitally sensitive (GS) neurons were studied by single-unit recording in acutely prepared estrous and anestrous cats which were decerebrated under sodium pentothal or anesthetized with urethane. Pontine unit responses to vaginal probing were very pronounced and stimulus-bound, and involved a variety of response patterns. Most of the pontine GS neurons also responded to nociceptive stimuli and to a lesser degree, to innocuous somatic, extragenital visceral, and auditory stimuli. Among pontine GS cells recorded in estrous cats, responsiveness to innocuous somatosensory stimuli was more prevalent than among units in anestrous preparations (71% vs. 40%), and on the average, the units in estrous cats responded to stimulation of more regions of the body than did comparable units in anestrous animals. In recordings from the medulla in the decerebrate preparations, exclusive responsiveness to vaginal stimulation was observed in 22% of the GS neurons, contrasting with earlier results from urethane-anesthetized animals in which a greater degree of specificity was found. A close anatomical proximity existed between some medullary GS neurons and cells of nucleus ambiguus, including antidromically identified recurrent laryngeal nerve motor neurons, and between pontine cells and the trigeminal motor nuclei. Antidromic responses of GS neurons to stimulation of the brain stem revealed a projection from medullary GS neurons to the lateral tegmental field of the pons. Relatively few pontine GS neurons projected to the ipsilateral medulla. A strong synaptic influence upon medullary GS neurons, possibly or midbrain origin, descends from the lateral tegmental field of the pons.

Animals↗