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Biomedical subjects

J D Price

Publications and source records attributed to J D Price.

64 records · Page 4Linked to original sources
PubMed1966

Glomerulonephritis: a review based on 52 renal biopsies.

The pathological findings in 52 renal biopsies are described, with emphasis on the changes seen in glomerulonephritis. There were 12 cases of poststreptococcal glomerulonephritis, eight of idiopathic membranous glomerulonephritis, and 10 of lipoid nephrosis. Poststreptococcal glomerulonephritis is subdivided into acute and persistent phases, and the latter is further defined as subacute, latent or chronic. The characteristic but not specific lesion of post-streptococcal glomerulonephritis is the development of mesangial scars. In lipoid nephrosis there are subendothelial deposits in the glomerulus. Membranous glomerulonephritis is characterized by massive heterogeneous deposits on the outside surface of the basement membrane. It is concluded that there are three well-defined types of glomerulonephritis, and although future studies may reveal interrelationships, the clinical and pathological evidence to date is sufficient to warrant their separate classification.

Adolescent↗
PubMedDate not supplied

In vitro studies using ion exchange resins as potential phosphate binders for renal failure patients.

The uptake of phosphate [expressed as phosphorus (P)] by the anion exchange resins, Dowex 1-X8, Dowex SBR, and Bio-Rex 5, aluminum hydroxide, and sucralfate tablets was evaluated. The maximum uptake capacities (in mg P per gram of "wet" resin or solid) were 56, 49, and 84 mg for Dowex SBR, Dowex 1-X8, and Bio-Rex 5 resins, respectively, and 164-168 mg for aluminum hydroxide and sucralfate. At a concentration of P considered to approximate that encountered in the stomach (0.3 mg/ml), Bio-Rex 5 resin, aluminum hydroxide, and sucralfate bound similar amounts of P. Physiologic concentrations of bicarbonate or chloride and simulated gastric or intestinal fluids caused small changes in P uptake by Bio-Rex 5 resin. The resins bound large quantities of taurocholic (TA) and glycocholic (GA) acids. However, when Bio-Rex 5 was converted to the taurocholate form, it bound the same amount of P as the original chloride-form resin, and the binding of TA was prevented.

Aluminum↗