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Biomedical subjects

J D Oriel

Publications and source records attributed to J D Oriel.

At least 37 records · Page 2Linked to original sources
PubMed1988

Efficacy of ofloxacin in the treatment of non-gonococcal urethritis in men and genital infections caused by Chlamydia trachomatis in men and women.

The efficacy of ofloxacin was evaluated in 30 men with non-gonococcal urethritis (NGU) and 17 women with Chlamydia trachomatis infection of the cervix. All were treated with ofloxacin 200 mg twice daily for seven days. Before treatment, Ch. trachomatis was isolated from 11 (37%) of the 30 men with NGU. Of these 30 men, the symptoms and signs of urethritis were eliminated in 20 (67%) two weeks after completion of ofloxacin therapy. Ch. trachomatis was not re-isolated from any of the 11 men with positive isolation before treatment. All of the group of 17 women with Ch. trachomatis infection of the cervix had complete cure two weeks after completion of ofloxacin treatment. Ofloxacin appears to be an effective treatment for lower genital tract infections with Ch. trachomatis in men and women and its efficacy in NGU appears to be comparable to standard tetracycline therapy.

Adolescent↗
PubMed1988

Isolation of Chlamydia trachomatis from endometriums of women with and without symptoms.

Chlamydia trachomatis was isolated from the endometrial cavities of three out of 19 women with positive cervical cultures, who were all symptomless sexual contacts of men with non-gonococcal urethritis (NGU). C trachomatis was recovered from the endometrial cavities of four out of 14 women with pelvic inflammatory disease (PID), three of whom had positive cervical cultures. Although endometrial biopsy is probably not justifiable as a routine procedure, it may be a useful adjunct to endocervical investigations for managing women with PID.

Chlamydia trachomatis↗
PubMed1988

Subclinical penile human papillomavirus infection and dysplasia in consorts of women with cervical neoplasia.

Fifty men whose sexual partners were 50 women with histologically proved cervical intraepithelial neoplasia (CIN) grade III (severe dysplasia or carcinoma in situ) were studied. A further 25 men whose current regular sexual partners were 25 women with chlamydial cervicitis were recruited as controls. If either of the partners in either group had genital condylomata acuminata or a known history of similar lesions, the couple was excluded from the study. Abnormal penile epithelium, which was detected by colposcopy after application of 5% acetic acid to the penile skin, was reported in 25 men in the study group compared with three in the control group. Histologically proved subclinical penile infection with human papillomavirus (HPV) was present in 23 men in the study group compared with three in the control group (p less than 0.01). Of the 50 men in the study group, four had histologically proved severe penile dysplasia or carcinoma in situ with evidence of HPV infection, the disease being subclinical in each case and diagnosed on histology of a specimen obtained by colposcopically directed biopsy. HPV DNA was detected on filter hybridisation of penile scrapes from 15 of the 23 men in the study group with histologically proved penile HPV infection, HPV16 DNA being detected in 10 of them. HPV DNA was detected on DNA-DNA hybridisation of biopsy material in seven of 18 men with histologically proved penile HPV infection. Five of these biopsy specimens were positive for HPV16 DNA. Only one man in the control group had HPV DNA detected in a penile scrape. This patient had histologically proved subclinical penile HPV infection. Such lesions may represent an important male reservoir of HPV types implicated in genital squamous carcinogenesis in both sexes.

Adult↗
PubMed1987

Detection of Trichomonas vaginalis antigen in women by enzyme immunoassay.

An enzyme immunoassay (EIA) was developed for the detection of Trichomonas vaginalis antigen in vaginal swabs. Four hundred and eighty two women attending a sexually transmitted disease (STD) clinic were tested; 44 (9.1%) were positive by culture, 32 (6.6%) were positive by wet film examination, and 54 (11.2%) were considered to be positive for trichomonal antigen by EIA. Taking culture as the reference method, the EIA had a sensitivity of 93.2% and a specificity of 97.5%. The predictive value of a positive test was 82% and that of a negative test was 99.3%.

Antibody Specificity↗
PubMed1986

Ciprofloxacin in the treatment of gonorrhoea and non-gonococcal urethritis.

The treatment of gonococcal infections by quinolones is reviewed. Acrosoxacin is effective, but side effects are relatively common. Ciprofloxacin is effective in single dosage against urogenital gonococcal infections, and probably also against rectal and pharyngeal infections. It is effective against infections by penicillinase-producing Neisseria gonorrhoeae. In vitro, ciprofloxacin is active against Chlamydia trachomatis, and preliminary results indicate that this drug may be of value in the treatment of non-gonococcal urethritis and chlamydial infection. No major side effects of ciprofloxacin therapy in patients with these infections have been reported.

4-Quinolones↗
PubMed1986

Aetiology of urinary symptoms in sexually active women.

Two hundred and fifty six unselected women, 50 of whom had urinary symptoms (frequency of urination or dysuria, or both), and who were attending a department of genitourinary medicine, were investigated. The urinary symptoms were associated both with pyuria and the isolation of undoubted pathogens from midstream urine (MSU) specimens. No associations were found between urinary symptoms and the isolation of Neisseria gonorrhoeae or Chlamydia trachomatis from the urethra or cervix; the recovery of Mycoplasma hominis from the urethra, cervix, or MSU; the recovery of Trichomonas vaginalis or Candida albicans from the vagina; or the presence of bacterial vaginosis. Urethral leucocytosis was associated with the isolation of T vaginalis but not with the recovery of N gonorrhoeae, C trachomatis, C albicans, or urinary pathogens. Pyuria was associated with the isolation of urinary pathogens and with the presence of trichomoniasis; it was not associated with the recovery of C trachomatis or M hominis.

Adolescent↗