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Biomedical subjects

J D North

Publications and source records attributed to J D North.

At least 37 records · Page 2Linked to original sources
PubMed1969

Use of antilymphocyte globulin after cadaveric renal transplantation.

Antilymphocyte globulin (A.L.G.) was prepared by injecting fresh frozen splenic cells subcutaneously into horses. The IgG fraction of the serum was concentrated by a batch technique using diethylaminoethanol-Sephadex. Fourteen patients given this material by intramuscular injection after cadaveric renal transplants, in addition to azathioprine and prednisone, had less evidence of rejection compared with patients previously treated with azathioprine and prednisone only, despite a reduction of the mean daily prednisone dose from 65 to 45 mg. Toxicity, especially local reaction, fever, and hypotension, limited the amount of A.L.G. that was given.

Animals↗
PubMed1968

Reticulum cell sarcoma after renal homotransplantation and azathioprine and prednisone therapy.

Two patients developed reticulum cell sarcomata after they had been treated with azathioprine and prednisone in the course of cadaveric renal transplantation. Both had terminal widespread herpes simplex virus infection.Immunosuppressive therapy could be responsible for an increased risk of malignant lymphomata either directly or by facilitating infection with oncogenic viruses.

Adult↗