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J D Mull

Publications and source records attributed to J D Mull.

28 records · Page 2Linked to original sources
PubMed1979

Assignment: Arabia.

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PubMed1973

Immunity to chlamydial infections of the eye. II. Studies of passively transferred serum antibody in resistance to infection with guinea pig inclusion conjunctivitis.

Conjunctival infection of guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis confers immunity. However, the mechanism of resistance to this intracellular pathogen is not yet defined. In the study reported here, serum immunoglobulin was passively transferred with resultant titers in excess of those known to be associated with immunity. Nonetheless, when the passive transfer recipients were challenged, they acquired infection which was neither delayed nor attenuated. Eye secretion antibody titers appeared and increased only after 11 days of infection in both passive transfer recipients and control groups, suggesting but not proving de novo local synthesis of secretory antibody. This study suggests that cellular or secretory immune mechanisms may predominate in resistance to this infection.

Animals↗
PubMed1973

Immunity to chlamydial infections of the eye. V. Passive transfer of antitrachoma antibodies to owl monkeys.

Previous studies have shown that owl monkeys which have had a trachoma agent infection were subsequently highly resistant to challenge by both homologous and heterologous organisms. In the present study, passive transfer of owl monkey serum containing antitrachoma antibody from immune monkeys did not protect recipient monkeys from infectious challenge with homologous trachoma. Antibody was not detectable in eye secretions of the recipient monkeys until the intensity of infection was waning, suggesting but not proving that local antibody synthesis rather than simple transudation of serum antibody occurs.

Animals↗
PubMed1970

Immunoglobulins, secretory component, and transferrin in eye secretions of infants in regions with and without endemic trachoma.

Eye secretions were collected from Boston and Saudi Arab infants between 1 day and 6 months of age. These secretions were then tested with monospecific antisera in double diffusion and immunoelectrophoresis for the presence of immunoglobulin (Ig)A, IgM, IgG, secretory component, and transferrin. (The term "secretory component" has been chosen by the World Health Organization to replace the terms "secretory piece" and "transport piece.") Eye secretions of all newborns contained secretory component. IgA was found attached to the secretory component in samples from some infants as young as 8 days of age and in samples from most infants over 3 weeks of age. IgG and transferrin were found in most samples regardless of the age of the infant. The prevalence of the respective proteins in the eye secretions of Boston infants was found to be similar to their prevalence in the eye secretions of Saudi Arab infants, including four who developed trachoma during the study. Specific antibody to trachoma was demonstrated in the eye secretions of those infants with active trachoma, and the immunoglobulin class was determined.

Journal Article↗