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Biomedical subjects

J D Moore

Publications and source records attributed to J D Moore.

At least 433 records · Page 24Linked to original sources
PubMed1986

Acute effects of smoking marijuana on hormones, subjective effects and performance in male human subjects.

Four healthy male subjects smoked two marijuana cigarettes or one marijuana cigarette and one placebo cigarette, or two placebo cigarettes on separate days in a random order crossover design. Each marijuana cigarette contained 2.8% delta-9-tetrahydrocannabinol (THC). Plasma hormones and THC were measured before and after each smoking session. Plasma LH was significantly depressed and cortisol was significantly elevated after smoking marijuana. Nonsignificant depressions of prolactin, FSH, testosterone and free testosterone and elevation of GH also occurred. Concurrent measures of subjective effects via subscales of the Addiction Research Center Inventory, Single Dose Questionnaire and a Visual Analog Scale were generally elevated. Significant impairment on a psychomotor performance task paralleled elevations in subjective effects, hormone effects and peak THC determinations. Although all the hormone effects were within normal basal ranges, interactions between these systems, and their effects on behavior cannot be discounted.

Adrenocorticotropic Hormone↗
PubMed1985

Morphofunctional investigations on spontaneous pituitary tumors in Wistar rats.

Adenoma of the pituitary gland represents one of the commonest spontaneous tumors in strains of laboratory rats. In a retrospective survey of pituitary glands from 2165 albino Wistar rats, the total number of pituitary adenomas was 501, representing an overall incidence of 23% with females showing a higher incidence (32%) than males (13%). Pituitary adenoma was rare from 6-52 weeks of age and accounted for only 0.2% of the total incidence. The first pituitary tumors in this series were observed at 32 weeks in 2 female rats and at 40 weeks in a male rat. From 52-85 weeks of age, incidence remained low, and then increased progressively in animals that died from 85-110 weeks of age. In a series of 200 Wistar rats, detailed evaluation was completed for neoplastic and hyperplastic lesions of the pituitary gland. The immunocytochemical characteristics of the pituitary adenoma were investigated using markers for prolactin, growth hormone, and thyrotropic hormone. Positive immunoperoxidase staining revealed an incidence of 59% prolactinomas in both male and female rats. Forty-one percent of pituitary adenomas did not stain for prolactin, thyrotropic, or growth hormone and showed no specific morphologic differences from prolactinomas. The application of immunoperoxidase-staining techniques offers a useful tool for characterizing secretory activity of pituitary adenomas and evaluating histopathologic changes of the pituitary gland.

Adenoma↗
PubMed1982

Biofeedback treatment of dysmenorrhea.

Nine dysmenorrheic women were run in EMG and thermal biofeedback procedures with concurrent autogenic relaxation practice. Significant reductions in subjective estimates of symptomology associated with dysmenorrhea were noted in all subjects. EMG levels correlated positively with the reductions in symptoms. Thermal levels did not correlate with EMG. In fact no consistent patterns in thermal measures were noted. However, thermal biofeedback cannot be ruled out as an effective treatment for dysmenorrhea since reductions in symptoms occurred during thermal biofeedback training. Another significant aspect of the present study is the effectiveness of long treatment procedures. A six month period was employed and significant reductions in symptoms were noted following two months of biofeedback treatment. Finally, the importance of beginning biofeedback treatment prior to onset of menstrual symptoms is indicated.

Adult↗
PubMed1982

Onset of puberty in heifers of diverse beef breeds and crosses.

Puberty traits of straightbred and crossbred heifers (n = 301) were evaluated under pasture conditions. Breed groups represented were straightbred Hereford and Red Poll, reciprocal crosses of these two breeds, Angus X Hereford, Angus X Charolais-Cross, Brahman X Hereford and Brahman X Angus. Breed group was an important (P less than .01) source of variation in heifer weights and in age at puberty. Straight-bred Red Poll and Red Poll cross heifers were youngest at puberty, Angus X Hereford and Angus X Charolais-Cross were intermediate, and straightbred Hereford and Brahman crosses were oldest at the onset of puberty. At the beginning of their first mating season at 19.5 mo of age, 96% of the straightbred Red Polls, 95% of Red Poll crosses, 81% of Angus X Herefords, 89% of Angus X Charolais-Crosses, 68% of straightbred Herefords, 48% of Brahman X Herefords and 74% of the Brahman X Angus had attained puberty. Results of a diallel analysis of Hereford-Red Pool matings indicated that maternal influence of the Red Poll breed was superior (P less than .01) to Herefords for body weight up to 24 mo of age and incidence of puberty at 11.5 mo. Red Polls also exceeded Herefords in direct effects for puberty percentage at 11.5, 15 and 19.5 mo of age. Heterosis was significant for puberty percentage and weight. Breed group differences in pregnancy rate at 24 mo were not significantly.

Animals↗
PubMed1981

Effects of EMG and thermal feedback training on tinnitus: a case study.

This case report describes a patient who exhibited the usual complaints of frustration, annoyance, and lack of sleep associated with severe tinnitus. After 2 months of weekly biofeedback sessions along with home training with a portable thermal biofeedback unit, the patient was relieved of the psychological symptoms associated with the tinnitus. A 1-year follow-up demonstrated that the patient remained complaint-free of psychological symptoms although the subjective loudness of the ringing was judged to be the same as at the onset of the tinnitus. The results indicate that biofeedback is a useful procedure in the treatment of severe tinnitus.

Adolescent↗
PubMed1979

REM sleep deprivation increases preference for novelty in rats.

As a further test of the hypothesis that REM deprivation decreases fear, the behavior of 40 male rats was measured in a Y-maze adapted to test for preference for novelty. Prior to this test, the animals were exposed for 4 days to one of four treatments, i.e., either a dry environment control, a wet environment control, a 2-day REM deprivation period or a 4-day REM deprivation period. During the test both number of grid crossing in the novel and non-novel arms of the Y-maze and three indices of emotionality were recorded. The results were congruent with data we had reported earlier and offered convincing evidence in support of the hypothesis.

Animals↗