Three-dimensional (3D) fast spin-echo (FSE) imaging can produce contiguous thin sections for high-quality multiplanar reconstructions. Such reformatted images may be useful in the evaluation of three-dimensionally complex, curvilinear anatomic structures such as the hippocampus. The authors describe a 3D FSE protocol for T2-weighted imaging of the hippocampus. The protocol uses an overlapping-multiple-slab imaging strategy to decrease imaging times and a modified refocusing radio-frequency pulse train to improve the reformatted images. The authors describe their parameter optimization, discuss the benefits and limitations of the new sequence, and present representative images of healthy volunteers.

Artifacts↗

PubMedDate not supplied

Secondary alexithymia: an empirical validation.

Alexithymia is described as both a primary personality trait and a secondary state reaction to medical illness. To empirically study secondary alexithymia, a series of medically ill patients seen in psychiatric consultation were compared with a healthy control population. Measured by the Toronto Alexithymia Scale (TAS), the medically ill were more alexithymic than the healthy population. Alexithymia was best predicted by both depressed mood and lowered quality of life, rather than by the categorical ranking of the severity of the medical illness. Alexithymia did appear to be separate from self-reported mood. These data support the concept of secondary alexithymia.

Activities of Daily Living↗

PubMedDate not supplied

Spontaneous and mutagen-induced sister chromatid exchange in motor neurone disease.

Spontaneous and mutagen-induced sister-chromatid exchange frequencies have been studied in the peripheral blood lymphocytes of 6 patients with motor neurone disease. Their values were compared with those obtained in age- and sex-matched healthy controls. No significant differences were observed between the 2 groups. These results do not support the hypothesis of a defect in the repair of DNA damage as the primary abnormality in the development of the disease.

Amyotrophic Lateral Sclerosis↗

PubMedDate not supplied

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