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Biomedical subjects

J D Mathews

Publications and source records attributed to J D Mathews.

130 records · Page 8Linked to original sources
PubMedDate not supplied

Vasoactivity generated from platelets by immune complexes in pre-eclampsia.

Circulating immune complexes in excess of the equivalent of 20 micrograms/ml heat-aggregated IgG were found in fourteen out of twenty patients diagnosed as having preeclampsia. Only six of the nineteen controls tested had similar levels of immune complexes. Recent studies have established that concentrations of heat aggregated IgG in excess of 20 micrograms/ml activate human platelets to release sufficient concentrations of vasoactive agents to constrict a human blood vessel in vitro. It is therefore suggested that in vivo platelet activation by circulating immune complexes may release sufficient concentrations of vasoactive agents to contribute to the hypertension in pre-eclampsia.

Antigen-Antibody Complex↗
PubMedDate not supplied

Analysis of variation in blood lead levels in Melbourne families.

Blood lead levels were measured in 651 subjects, aged from six to 91 years, from 83 Melbourne families. Lead levels were higher in males than in females, and increased with age (to 60 years), with haematocrit, and with cigarette smoking. Blood lead levels tended to increase with levels of blood pressure, and this weak positive correlation persisted after adjusting for age and sex differences. Blood lead levels were similar in members of the same family; the familial correlation was greatest for siblings during childhood, and least for spouses. This suggests that shared (home) environment has a greater influence on blood lead levels in young people than on those in adults. Over all, our findings highlight the importance of environmental factors as causes of variation in blood lead levels, and the importance of quality control in studies of blood lead.

Adolescent↗