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Biomedical subjects

J D Mathews

Publications and source records attributed to J D Mathews.

At least 109 records · Page 6Linked to original sources
PubMed1976

Alcohol use, hypertension and coronary heart disease.

1. Male death rates from hypertension and stroke in England and Wales in 1949-53 were highest in those socio-economic and occupational groups with the highest death rates for cirrhosis of the liver (and presumably with highest alcohol intake. 2. In prevalence data from the Busselton population in Western Australia in 1969, there was a significant association between hypertension and a history of heavy drinking. 3. Together with other data, these observations suggest that up to 30% of hypertension in affluent countries may prove to be attributable to the use of alcohol.

Adult↗
PubMed1975

Ischaemic heart-disease: possible genetic markers.

National death-rates from ischaemic heart-disease are significantly correlated with population frequencies of histocompatibility antigen HLA-8 and haplotype 1-8. Serum-cholesterol levels may also be correlated with population frequencies of HLA-8. Inexplicably high death-rates from ischaemic heart-disease and high levels of serum-cholesterol in Finland may be due to the combined effects of HLA-8 and W15. It is suggested that HLA-8 (and possibly W15) are linked to genes which predispose to hypercholesterolaemia and ischaemic heart-disease. These findings provide some support for i-munogenetic hypotheses for vascular disease in man.

Autoimmune Diseases↗