Search PubMed⌕ Search

Biomedical subjects

J D Langdon

Publications and source records attributed to J D Langdon.

At least 19 recordsLinked to original sources
PubMed1994

Frequent deletion of chromosome 3p in oral squamous cell carcinoma.

Evidence suggests that the accumulation of genetic lesions in dominant oncogenes and tumour suppressor genes is involved in the development of human cancers. We have used restriction fragment length polymorphism analysis to identify chromosomal deletions which may indicate the location of potential tumour suppressor genes. Deletion of chromosome 3p was found in 17/21 (81%) of informative primary oral squamous cell carcinoma (SCC) using a polymorphic probe recognising the D3F15S2 locus (3p21). Loss of heterozygosity (LOH) was not confined to patients exposed to recognised risk factors such as heavy smoking or alcohol consumption and was present at an early stage in the disease suggesting that this genetic alteration may be a fundamental event for oral cancer.

Adult↗
PubMed1994

Repair of the radial forearm flap donor site with a full-thickness graft.

A method of closing the radial forearm free flap donor site defect with a defatted, full-thickness skin graft is described. Its advantages of improved patient mobilization, protection of tendons, and cosmesis are discussed with reference to 16 consecutive patients treated over a period of 1 year.

Abdomen↗
PubMed1992

Expression of the tumour suppressor gene p53 in oral cancer.

In this preliminary series, the product of the tumour suppressor gene p53 was detected in 12/15 cases of oral squamous cell carcinoma (SCC) and in two cases of leukoplakia. The tumours either expressed the mutant form of p53 throughout the specimen or contained focal areas of positive cells. p53 expression was commonly observed in tumours obtained from patients who were heavy smokers and drinkers suggesting that alterations in the p53 gene may be one of the sites of genetic damage in this group of patients.

Alcohol Drinking↗
PubMed1992

Infantile fibromatosis with involvement of the mandible.

Two unusual cases of infantile fibromatosis involving the mandible occurring in 2-year-old children are described. These tumours, though initially highly aggressive, underwent spontaneous regression in the absence of definitive treatment.

Cell Nucleus↗
PubMed1991

A simple method for fixation of post-condylar cartilage grafts.

The use of the post-condylar cartilage graft for the treatment of retrognathia in adolescent patients has in the past been complicated by spontaneous displacement of the graft. Although a reliable method of fixation has evolved, the technique is not simple. The method described here is simple and provides secure immobilisation of the graft in the post-condylar space. A prospective study is needed to evaluate the long term success of this technique.

Bone Screws↗
PubMed1991

Titanium mesh (TiMesh) osteosynthesis: a fast and adaptable method of semi-rigid fixation.

Titanium mesh has been used in the USA for the fixation of fractures of the facial skeleton since the Vietnam war. Despite the increasing use of titanium mesh osteosynthesis for trauma, orthognathic and reconstructive surgery in the USA, it is only in recent years that it has gained acceptance in Europe. This paper appraises the original titanium mesh osteosynthesis system (TiMesh) in a wide range of surgical contexts in the maxillofacial region. It has been found to be quick and reliable in placement, highly adaptable and to have considerably reduced the operating time. Its further potential advantages in reducing stress-shielding and improving functional bone healing due to its semi-rigid nature are discussed.

Bone Screws↗
PubMed1991

Complications of pharyngostomy.

An account is given of a fatal complication following the use of a pharyngostomy feeding tube. The literature on this topic is reviewed with regard to complications. Of the 671 patients that have been reported previously there have been no fatal or serious complications and minor complications were reported in only 42 patients. We regard the technique of pharyngostomy to be safe but recommendations are made to avoid the complication reported here.

Aged↗
PubMed1991

Temporomandibular joint eminence augmentation by down-fracture and inter-positional cartilage graft. A new surgical technique.

A new surgical technique for the treatment of recurrent temporomandibular joint subluxation or dislocation is described. Following a horizontal osteotomy and down-fracture of the articular eminence an inter-positional bovine cartilage xenograft is inserted in order to augment the vertical height of the eminence. The procedure combines simplicity with minimal post-operative morbidity. The increase in eminence height is both predictable and stable.

Cartilage↗
PubMed1991

The inferiorly based masseter muscle flap: anatomical basis for its use in head and neck reconstructive surgery.

The aim of this study was to investigate and elucidate the anatomical basis for the use of the inferiorly based masseter muscle flap in the reconstruction of oropharyngeal defects after ablative surgery. The anatomy of the masseter muscle, with particular emphasis on its blood supply, was studied using plain and coloured resin injected dissections and a series of digital subtraction angiograms and external carotid arteriograms. Both techniques were demonstrated to be reliable and effective means of anatomical investigation of blood vessels. The vascular anatomy of the masseter muscle and the anatomical and angiological results as well as a case report are described. The masseter muscle, when used as an inferiorly based flap, provides the necessary bulk for reconstruction of moderate size defects in the lateral border of the tongue, posterior floor of the mouth, retromolar trigone, anterior tonsillar pillars and lateral pharyngeal wall. Although the masseter muscle has small dimensions, it offers a reliable method of reconstruction in selected defects without the disadvantages of cosmetic and functional loss.

Angiography, Digital Subtraction↗
PubMed1991

Secondary alveolar bone grafting in clefts of the lip and palate.

A short review of the literature is presented outlining the role of alveolar bone grafting in cleft patients. An analysis of a series of 47 secondary alveolar bone grafts in 34 patients is presented. The age range was 7-24 years. At the time of evaluation, 30 canines were in final occlusion and good alveolar bone levels were present in 83% of patients. Of the 13 bilateral cases (26 clefts), 14 canines were in final occlusion and all cases had good alveolar bone levels. No major complications were encountered. The graft was completely resorbed in 3 cases (6.4%) only.

Adolescent↗
PubMed1990

A preliminary report using oxethazaine--a potential new dental local anaesthetic.

Oxethazaine is the most potent local anaesthetic in use. It is claimed to be 2000 times more potent than lignocaine and 500 times more potent than cocaine as assessed in rabbits eyes. Currently, oxethazaine is used in an antacid preparation for the topical relief of pain in conditions such as hiatus hernia, where the local pH is very low. Since oxethazaine is active in an acidic environment, it was decided to use oxethazaine, in a pilot study of 20 patients requiring minor oral surgery procedures, at a concentration of 0.1% at pH 3, to assess its value in achieving dental local anaesthesia. It was found that the local anaesthesia achieved was sufficient in all patients to allow the operative procedure to proceed. In two of the patients, who presented with acute periapical pathology, satisfactory local anaesthesia was achieved with 0.1% oxethazaine following a failure with lignocaine 2% and 1:80,000 adrenaline. The duration of anaesthesia was found to be similar to the average achieved with lignocaine 2% and 1:80,000 adrenaline.

Adult↗