Search PubMedSearch

Biomedical subjects

J D Kingham

Publications and source records attributed to J D Kingham.

16 recordsLinked to original sources

Photic maculopathy in young males with intraocular foreign body.

A young male with intraocular foreign body (IOFB) and clear media had successful removal of the IOFB but sustained macular damage and permanent loss of vision secondary to operating microscope phototoxicity. Light damage to the eye can be thermal, mechanical, or photochemical and is dependent on source and wavelength of light, filters, and host factors. Removal of IOFB is important, but surgeons must be aware of potential light damage to the macula in lengthy surgical procedures and take appropriate precautions.

Adult

Removal of preretinal blood during vitrectomy.

To remove preretinal blood from the posterior pole, balanced salt solution is irrigated into the eye through a 21-gauge needle. The needle previously used for infusion is used as a port of exit. I have treated seven patients with this method without harmful effects.

Blood

Myelogenous leukemia and bilateral exudative retinal detachment.

A 47-year-old woman with a diagnosis of myelogenous leukemia presented with poor vision secondary to bilateral exudative retinal detachments. Chemotherapy improved her leukemia status and her vision improved but her retinal pigment epithelium became diffusely mottled and irregular, presumably because of a toxic effect from the exudative subretinal fluid. Clinical and fluorescein findings are presented.

Exudates and Transudates

Retrolental fibroplasia.

Retrolental fibroplasia is more accurately referred to as retinopathy of prematurity. Host factors most clearly incriminated are the maturity of the infant and the time in oxygen therapy. A continuum of retinopathy ranges from abnormal arborization of terminal retinal vessels to a detached retina incorporated in a cicatrix behind the lens. Every high-risk infant should be examined by indirect ophthalmoscopy prior to discharge from the nursery. A thorough knowledge of the natural course of the disease is essential because many cases will resolve spontaneously.

Humans

Reticular dystrophy of the retinal pigment epithelium. A clinical and electrophysiologic study of three generations.

Reticular dystrophy of the retinal pigment epithelium is characterized by a posterior pattern of pigment clumping like a "fishnet with knots." Four patients in three successive generations were seen with typical reticular dystrophy. A fifth patient had abnormal dark adaptation. In this family reticular dystrophy was characterized by the typical reticular pigmentary pattern, good visual acuity, normal electroretinographic findings, abnormal electro-oculographic findings, and abnormal dark adaptation. The pedigree indicates autosomal dominance as the inheritance pattern.

Adolescent

Acute retrolental fibroplasia. II. Treatment by cryosurgery.

Fourteen eyes of 12 infants with acute retrolental fibroplasia were treated with cryotherapy. In only one or possibly two cases was treatment considered to be of positive value. Treatment in the remaining 12 cases was either ineffective or deleterlous. Surgical treatment is rarely, if ever, indicated and spontaneous resolution of retinopathic changes is still the most common course of the natural history of the disease. The role of the ophthalmologist in the perinatal intensive care nursery remains one of advisor to pediatricians and informant to parents of affected children.

Acute Disease

Temporal arteritis.

Temporal (giant cell) arteritis is a disease of older persons that has a variety of clinical presentations. It is a major cause of blindness. The erythrocyte sedimentation rate is almost always markedly elevated. Corticosteroidss in large doses are urgently required. The diagnosis is established by biopsy of an artery. In an 80-year-old women who sudddenly became blind, the signs had been masked by low doses of steroids given for a mistake diagnosis.

Adrenal Cortex Hormones

Acute retrolental fibroplasia.

Three hundred eighty-four premature infants were examined by indirect ophthalmoscopy in a period of 38 months. Sixty-eight were found to have some degree of retrolental fibroplasia. Most pathologic changes resolved spontaneously to normal or near normal. A classification was formulated, based on peripheral vascular changes, to enable observers to interpret and quantitate the amount of disease present. The role of the ophtalmologist in the perinatal intensive care nursery is not to dictate the amount of oxygen administration during the acute phase of respiratory distress syndrome but to monitor peripheral fundus and posterior vascular changes of infants of low birth weight, or who have received oxygen, or both, at a time that is not detrimental to the health of the infant. To evaluate the possible indications and efficacy of surgical intervention, an understanding of the natural course of the disease process is mandatory.

Acute Disease

Vitelliform macular degeneration.

Six patients had macular vitelliform lesions similar to those in Best's vitelliform foveal dystrophy but all had normal electro-oculograms (EOG) and no familial involvement. Two patients had an exudative form of degenerative chroidopathy. The remining four had vitelliform lesions of unknown etiology. Fluorescein angiography demonstrated slight hyperfluorescence through rarefied retinal pigment epithelium but no leakage occurred from perifoveal retinal capillaries. The diagnosis of vitelliform foveal dystrophy should be restricted to those patients who have the morphologic lesions, and abnormal EOG, and a contributory family history.

Adult

Persistent hyaloid with retinal detachment.

An 11-year-old female with acquired traction retinal detachment associated with persistent hyaloid responded with retinal reattachment by intravitreous surgical technique and scleral buckling.

Arteries