Biomedical subjects
J D Johnson
Publications and source records attributed to J D Johnson.
Proper respect.
There is no reason the expect that governmental and other efforts to regulate medical practice in the interest of cost containment will abate even though there is general skepticism that it will produce meaningful savings. In this situation, multispecialty group practices should continue to exploit the comparatively favorable climate that they now enjoy by insisting that their incentives and performances should replace outmoded models as benchmarks of efficiency and quality for the national agenda, especially as the sentiment for some sort of national health care system increases.
Toward efficacy, appropriateness and equity.
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Some questions of ethics.
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A new surgical needle for periodontology.
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The Canadian health care systems: lessons for American dentists.
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Toxoplasmosis and heart transplantation.
Our experience of toxoplasmosis in a series of 33 heart transplant cases was reviewed. One fatal infection was observed in a "mismatched" seronegative recipient of a heart from a seropositive donor. Two similar mismatched cases were given pyrimethamine prophylaxis and remained well. One organ recipient was found to have primary toxoplasmosis during the immediate preoperative assessment. The patient was treated with conventional therapy and remained asymptomatic in the postoperative period. Secondary reactivation of chronic infection and diagnostic confusion caused by passively acquired antibody associated with blood transfusion were not recorded. False reactions were noted in dye and latex agglutination test results.
Managing minor trauma during pregnancy.
While major trauma during pregnancy is usually managed in intensive-care units by critical-care nurses, obstetric nurses often care for patients who have experienced minor trauma. Obstetric nurses must understand the mechanisms of traumatic injury and the potential deleterious effects on mother and fetus. Nursing care of the pregnant victim of minor trauma is the focus of this article.
Schwannoma of the fifth digit.
The authors have presented a rare case of benign solitary schwannoma of the fifth digit. A case study involving this digit has not been reported previously. The lesion was simple to excise and provided no postoperative complications. Schwannomas may produce pain, parasthesia, hypesthesia, and occasionally motor and sensory deficits. Because the lesion is a nerve sheath tumor, it usually can be separated from the nerve. Simple excision is recommended because the tumor rarely becomes malignant. The tumor should be diagnosed correctly in order to rule out neurofibromatosis-1, neurofibroma, or malignant schwannoma. This can be performed during biopsy by observing for the presence of Antoni type A or type B cells, and through other distinguishing characteristics, such as encapsulation, singularity of the tumor, and lack of skin pigmentation changes. Benign schwannomas rarely recur.
Recognition and management of personality styles and disorders in dental practice.
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Pharmacokinetic analysis of potassium cyanate in mice using whole blood and expired air.
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Treatment of chronic atrophic oral candidiasis with ketoconazole (Nizoral): a case report.
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Studies on the effects of dansylcadaverine and related compounds on receptor-mediated endocytosis in cultured cells.
It has been suggested that cellular transglutaminases may play an important role in the process of receptor-mediated endocytosis. We have examined this premise by investigating the receptor-mediated endocytosis of two proteins, epidermal growth factor and alpha 2 macroglobulin in cells that are deficient in transglutaminases. We find that endocytic activity is normal in these cells, ruling out an obligatory role for transglutaminases in endocytosis. We do find, however, that dansylcadaverine is not an inhibitor of endocytosis in cells that lack transglutaminase activity. Immunofluorescent localization of dansylcadaverine in dansylcadaverine-treated cells demonstrates incorporation of the amino into endocytic vesicles. We believe that covalent coupling of dansylcadaverine to cellular membranes may account for its ability to interfere with endocytosis in certain susceptible cells.
Biotransformation and elimination of 14C-flecainide acetate in humans.
The metabolism of 14C-flecainide acetate, a new antiarrhythmic, was investigated in four healthy human subjects, after a single, 200-mg oral dose. The cumulative recovery of radioactivity ranged from 81 to 90% (mean, 86%) in urine and from 4 to 6% (mean, 5%) in feces; thus, flecainide does not appear to undergo extensive biliary excretion, unless reabsorption occurs after biliary elimination. The cumulative excretion in urine of unchanged flecainide ranged from 35 to 50% (mean, 42%) of the dose and was essentially complete by 72 hr postdose. Peak plasma levels of radioactivity (524 to 848 ng eq/ml) and of unchanged flecainide (214 to 281 ng/ml) were attained at 2 to 3 hr postdose. The average half-life for the disappearance of unchanged flecainide from plasma was about 16 hr; disappearance of total metabolites from plasma was only slightly slower. Radiomonitored TLC analysis showed that urine contained two major metabolites and two or three minor ones; both major metabolites were extensively conjugated. By TLC, NMR, and mass spectral comparisons to reference compounds, the two major urinary metabolites were shown to be meta-O-dealkylated flecainide and the meta-O-dealkylated lactam of flecainide. Most of the radioactivity in urine was accounted for by flecainide and the two major metabolites.
Forensic odontology in the 1980's. Dental evidence of medicolegal and criminological significance.
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Concurrent ankle and subtalar joint arthrodesis.
The authors report on a new method for arthrodesing both the subtalar and ankle joints simultaneously. The technique uses a cannulated screw driven from the plantar aspect of the calcaneus and directed proximally through the subtalar and ankle joints. An inverted strut graft further supports and reinforces the ankle component anteriorly. Although one patient fractured the calcaneal-talar-tibial screw at 13 months postoperative, overall results of the five cases evaluated were excellent. Patient follow-up ranged from four to 54 months, with an average of 26 months.
Accessory peroneus brevis muscle.
The authors report an anomalous tendon during routine cadaver dissection. This accessory peroneus brevis tendon arose with the peroneus brevis muscle. The tendon passed through a channel in the peroneus tertius and inserted into the extensor hood apparatus of the fifth digit.