Biomedical subjects
Publications and source records attributed to J D Jansen.
We present the case of a patient who died of thymoma-induced immunological dysfunction. The neoplasm was unsuspected antemortem because of its location adjacent to the right hemidiaphragm. This appears to be the most caudad ectopic position yet encountered for a thymoma.
The characteristics of the rat epidydimal adipocyte beta-adrenoceptor have been examined using lipolysis and cyclic AMP accumulation in adipocytes as well as adenylate cyclase activity in fat cell membranes. The pA2 values corrected for binding to bovine serum albumin of the selective antagonists betaxolol (beta 1-selective) and ICI 118.551 (beta 2-selective) against noradrenaline or fenoterol-stimulated lipolysis were indicative of an atypical beta-adrenoceptor associated with the lipolytic response. Antagonism of isoprenaline-stimulated cyclic AMP accumulation in whole cells and adenylate cyclase activity in membranes yielded pA2 values to betaxolol, ICI 118.551 and (-)-propranolol, which suggested that the atypical beta-adrenoceptor was coupled to adenylate cyclase. Comparisons of the Ki values obtained in binding studies using [125I]-cyanopindolol with pA2 values obtained in adenylate cyclase experiments suggest that the typical beta 1-receptor identified with radioligand binding studies is not the only receptor site mediating stimulation of adenylate cyclase activity and lipolysis.
Careful, independent scientific reviews of issues of importance in mutagenesis and carcinogenesis evaluations have been made over the past seven years by a group of leading members of several environmental mutagen societies. The International Commission for Protection against Environmental Mutagens and Carcinogens (ICPEMC) supports five main committees concerned with general principles and has published working papers and reports on an unbiased scientific basis. The work and goals of the Commission are described and future plans outlined.
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