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Biomedical subjects

J D Hudson

Publications and source records attributed to J D Hudson.

28 records · Page 2Linked to original sources
PubMed1984

Evaluation of the hemagglutination treponemal test for syphilis.

The sensitivity and specificity of the hemagglutination treponemal test for syphilis (HATTS) was compared with the fluorescent treponemal antibody-absorption test (FTA-ABS) with 491 sera. Medical histories were obtained for 153 patients with seroreactivity in either treponemal test. Overall correlation with patient history was 96.7% for the FTA-ABS and 93.9% for the HATTS. False-negative HATTS occurred in primary, late-latent (greater than 2 years), and treated syphilis. The reproducibility of the HATTS and FTA-ABS is equivalent. HATTS is an acceptable treponemal confirmatory test for syphilis, but the FTA-ABS should be used to resolve diagnostic discrepancies.

Antibodies, Bacterial↗
PubMed1981

SEM of epithelial mediated wound in mice.

Wound edges are drawn together by a process known as wound contraction. Myofibroblasts are thought to mediate this contractile force. However, up to 25% of the surface area of a wound may close in the first few days, long before significant numbers of myofibroblasts appear in the wound bed. This suggests that another contractile force exists in the margins of the wound tissue. This force appears to be mediated by a band comprised of fusiform shaped epidermal cells. These cells are circumferentially distributed with respect to the wound margin. Microfilaments, similar in size to actin filaments and/or tonofilaments, can be observed in these cells. The filaments are aligned with the long axis of the epithelial cells that comprise the contractile band. Thus, wound contraction may in all likelihood be a biphasic phenomenon initially involving epidermal cells followed by the myofibroblasts.

Animals↗
PubMed1981

Morphological studies of experimental wound healing cells in a murine model.

Integument wounds are primarily healed by fibroblasts. These multifunctional cells synthesize collagen and ground substances (acid mucopolysaccharides) from which they fashion fibers and/or laminae. The fibers are formed in the upper layers of the wound by spindle shaped cells which initially grow along fibrin strands. This area of repair eventually becomes the papillary dermis of the scar. Flattened fibroblasts produce stacks of collagen laminae in the deep part of the wound. The laminae are initiated in the subpannicular region several mm behind the wound margin. The laminae grow centripetally and mature (thicken by collagen and ground substance deposition which is effected by subsequent fibroblast activity). The laminae become the reticular layer of the scar dermis. Thus, the collagenous architecture of a scar's connective tissue appears to be related to the shape of the cells involved in assembly.

Animals↗