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Biomedical subjects

J D House

Publications and source records attributed to J D House.

44 records · Page 3Linked to original sources

Elevated blood neutrophil concentration in mania.

Total, differential, and absolute blood cell counts were compared in 66 untreated manics and 178 untreated schizophrenics. Mania was associated with significantly higher total leukocyte counts (p less than .001), accounted for by a significant increase (p less than .0001) in the number of neutrophils. There were no significant differences between the two groups in any other blood cell elements. Using normative values, manic patients had significantly higher frequencies of both leukocytosis (25.8% vs. 12.4%) and neutrophilia (34.8% vs. 12.4%) than the schizophrenic group. These data suggest a significant association between leukocytosis, neutrophilia, and mania.

Adult↗

Depression, cortisol metabolism and lymphocytopenia.

Depression is often associated with hypercortisolemia. Because high levels of cortisol influence the distribution of different types of leukocytes in the blood stream, we examined the percentages and absolute numbers of circulating neutrophils and lymphocytes in 29 depressed patients who were nonsuppressors on the Dexamethasone Suppression Test (DST), 28 depressed patients who were suppressors on the DST, and 52 schizophrenic controls. We found no significant differences in either RBC or WBC counts in the 3 groups. There were, however, significant differences in the percentages of both neutrophils and lymphocytes as well as the absolute number of lymphocytes among the groups. These differences were mostly due to significantly lower lymphocyte percentages and absolute counts in the depression-nonsuppressor group. We also found a significant negative association between post-dexamethasone plasma cortisol concentrations and blood lymphocyte counts. These data suggest a close interaction between cortisol metabolism and lymphocyte regulation in major depression.

Depressive Disorder↗

The effect of taking a sexual history on the notation of sexually related diagnoses.

Many patients have questions or concerns about sex, but few talk directly about the subject with their physician. Including a sexual history during the physician-patient encounter is one way to indicate to the patient that discussing sexual concerns is appropriate. We observed that physicians at the University of Iowa Family Practice Center were divided into two groups: those who routinely include a sexual history with a new patient and those who do not. Those physicians who claimed to routinely take a sexual history reported 33.3% of their patients had some type of sexual question, concern, or problem; those who claimed they do not include such a history reported only 9.5% had a sexual concern (P less than 0.05). Female physicians were less apt to take a sexual history than male physicians (11.8% v. 60%; P less than 0.001). We conclude that education in sexual history taking is an important part of the family practice curriculum for resident training.

Family Practice↗

Relationships between attitudes and use of adult-learning teaching activities by medical faculty.

This study examined teaching behaviors of medical faculty and their attitudes toward adult learners. A number of studies have examined characteristics of adult learners and found that certain teaching activities produce more effective learning in adults. Adult learners tend to be more self-directed and bring a variety of experiences to the educational setting; they also profit more from collaborative curriculum planning, learning activities, and evaluation of progress.

Attitude↗