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Biomedical subjects

J D Harrison

Publications and source records attributed to J D Harrison.

At least 145 records · Page 8Linked to original sources
PubMed1982

Ocular complications in haemodialysis and renal transplant patients.

115 patients on haemodialysis and 160 renal transplant patients were examined over an eight year period. A high percentage in both groups were found to have ocular complications. These included disorders of the cornea, lens, retina, choroid, and optic nerve. In contrast to other studies on renal transplant patients a relatively large number had symptoms and even required surgery for cataract removal. 65 (40.7%) had posterior sub-capsular cataracts. It is likely that nearly all were caused by the use of prednisone for immunosuppression. Of this number 25 (38.5%) had symptoms and 12 (18.5%) required cataract extraction. Pigmentary disturbances of the retinal pigment epithelium, together with vascular changes in the choroid were found in some. The implication of these relatively unknown complications, together with their possible aetiology, is discussed. The study emphasises the fact that all haemodialysis and renal transplant patients should be monitored for ocular complications.

Adolescent↗
PubMed1982

Tissue dilation during multiple cast restorative techniques.

The advantages and disadvantages of three tissue dilation methods are discussed. There are distinct, identifiable advantages in selecting electrosurgery as the method, since the disadvantages to each method are essentially equal. Electrode use and type are recommended for tissue dilation for the anterior and posterior areas of the mouth. The fully rectified surgical current is suggested since it provides a clean excision of the tissue and controls hemorrhage with a thin layer of coagulum. Illustrations demonstrate electrosurgical techniques with specific electrodes for both anterior teeth and posterior teeth. The margins for full coverage preparation can be finished to the crest of the tissue and a subgingival tissue trough established to the desired depth. This provides a space to refine the preparation margins to the desired sulcular depth prior to making the elastic impression. A number of clinical examples demonstrate effective and safe electrosurgical tissue dilation. Several cases illustrate the combination of tissue recontouring along with tissue dilation. Discipline application of electrosurgery for tissue removal is safe and provides excellent results. This benefits both the patient and the dentist.

Bicuspid↗
PubMed1980

The wound clearance and distribution of plutonium, americium and curium in rodents.

Wound contamination was simulated by the intramuscular injections of either 239Pu, 241Am or 244Cm nitrate in the hamster and by the subcutaneous injection of either 239Pu or 241Am nitrate in the rat. The actinides moved from the hamster muscle at approximately the same rate after injection of 370 Bq of each radionuclide (approximate 80 per cent cleared after 6 months). Similarly, the rates of translocation of 239Pu and 241Am in the rat were the same after injection of 370 Bq of each radionuclide (approximate 80 per cent cleared after 1 month). The clearance of 239Pu in the rat was slower after injection of 14.8 kBq and more rapid after injection of 20 Bq (approximately 40 per cent and 90 per cent moved after 1 month, respectively) while the movement of 241Am showed no dependence on the administered dose over the same range. The mixing of 239Pu and 241Am prior to intramuscular injection appeared to enhance the clearance of both radionuclides. The levels of accumulation of each actinide in the skeleton and liver of both species showed that they reached the circulation predominantly in soluble form. Some uptake of Pu and Am in regional lymph nodes was also observed, indicating that lymphatic clearance of polymeric material also took place.

Americium↗
PubMed1979

Some observations on the phosphatase cytochemistry of the submandibular gland of cat.

The localization of reaction product arising from incubation with thiamine pyrophosphate at pH 7.2 and beta-glycerophosphate or nitrophenylphosphate at pH 5 has been examined in central and demilunar acinar cells, myoepithelial cells, and cells of the striated ducts. Thiamine pyrophosphate reaction product was seen in the inner saccules of the Golgi apparatuses of the different types of cell. beta-Glycerophosphate and nitrophenylphosphate reaction products were seen in lysosomes, and in GERL-like structures in all except the cells of the striated ducts, in which the reaction products were observed in the Golgi apparatus. In central cells, the latter two reactions products were also seen in secretory granules and the cytosol.

Animals↗
PubMed1979

The gastrointestinal absorption of plutonium and americium in the hamster.

Plutonium-239 and americium-241 were administered to adult hamsters in various chemical forms and their absorption from the gut was measured. The results have been compared with published data on other species in order to derive values for the estimated absorption of these actinides in man. On the basis of current knowledge, the best values for adults would appear to be: 0.05% for americium, 0.01% for plutonium ingested in soluble form, and 0.0001% for plutonium ingested as the dioxide. Plutonium dioxide should be considered as soluble if a significant proportion (greater than 5%) of the activity is in particles less than 25 nm in diameter.

Administration, Oral↗
PubMed1979

Prevention of failures in making impressions and dies.

I have attempted to provide information that will help to prevent failures that occur during partial denture construction as a result of unsatisfactory fabrication of crowns. Methods of exposure of the preparation margins, provision of adequate bulk of the elastic impression material, proper selection of die construction, and the removable die technique were discussed.

Aluminum↗
PubMed1978

Experimental studies of the translocation of plutonium from simulated wound sites in the rat.

Wound contamination with plutonium was simulated in rats by injection into either muscle or subcutaneous tissue. The distribution after the injection of plutonium nitrate indicated that: (i) clearance from the contaminated tissue was due mainly to the movement of soluble complexes of plutonium, principally to the skeleton and liver, but also involved slower movement of polymerized, particulate plutonium to lymph nodes; (ii) clearance of soluble plutonium, and hence the overall state of clearance, was dependent on the tissue fluid flow through the contiminated tissue and the mass of plutonium deposited; (iii) lymphatic clearance of particulate plutonium resulted in the release of some particles into the circulation and subsequent uptake by the liver. Intramuscular deposition of small plutonium dioxide particles (approximately 1 nm in diameter) resulted in a greater rate of clearance of plutonium than deposition of the nitrate. Although the solubility of these particles was evident from the level of skeletal uptake of plutonium, a high level of excretion indicated that some plutonium was filtered into the urine in an undissolved form.

Animals↗
PubMed1977

Amalgam tattoos: light and electron microscopy and electron-probe micro-analysis.

A common tattoo occurring in the mouth is caused by the insertion of amalgam filling material into the soft tissues. Fifteen amalgam tattoos were examined. Amalgam or its derivatives were found within macrophages, fibroblasts and multinuclear giant cells. Fine particles were found associated with: the basement-membranes of mucosal epithelium, of striped muscle fibres, and of muscle cells of blood vessels; collagen; elastic tissue; and the connective tissue of nerves. Amalgam consists mainly of mercury, silver and tin. The analytical results suggest that corrosion occurs and that mercury and some tin are lost from the tattoos, leaving silver and tin in macrophages and giant cells, and silver in fibroblasts and in the above-mentioned extracellular sites.

Biopsy↗
PubMed1977

[Not Available].

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Denmark↗