Search PubMed⌕ Search

Biomedical subjects

J D Hare

Publications and source records attributed to J D Hare.

51 records · Page 3Linked to original sources
PubMed1967

Analysis of hamster tumor cell lines isolated from single colonies soon after induction by polyoma strains differing in transplant antigen production.

Tumor cell colonies, arising after the infection of hamster embryo cells with two strains of polyoma virus (PV) which differed in their capacity to induce the PV-specific transplant antigen, were isolated and studied for their transplant and tumor or "T" antigen content and growth characteristics in vitro and in vivo. Four of four tumor lines induced by the transplant immunogenic 3049 strain contained the transplant antigen, while only one of seven lines induced by the immunogenically deficient sp-D strain showed direct evidence for this antigen. T antigen was not detected by immunofluorescence in three tumor lines induced by the 3049 virus which contained the polyoma transplant antigen. No differences in growth capacity on plastic, in agar, or in the hamster subcutaneous tissue were apparent in spite of significant differences in transplant antigen content among the clones.

Animals↗
PubMedDate not supplied

Transplant immunity in hamsters treated with ultrasound.

Hamsters with subcutaneous fibrosarcomas were treated by excision and by exposure to 5-MHz ultrasound for six minutes at an intensity of 3 W/sq cm. Rates for successful elimination of the tumors were between 80% and 90% and were not significantly different for the two methods of treatment. After 30 days, the animals were challenged with the same tumor cells. Animals successfully treated with ultrasound or excision required at least 10 times as many cells to produce a tumor as controls, indicating that eradication of the tumor by ultrasound induced a level of transplant immunity at least as good as that resulting from surgical excision.

Animals↗