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Biomedical subjects

J D Guieu

Publications and source records attributed to J D Guieu.

113 records · Page 7Linked to original sources
PubMedDate not supplied

Study of circadian melatonin secretion pattern at different stages of Parkinson's disease.

To explore changes in melatonin secretion patterns and biologic rhythms in Parkinson's disease patients with or without levodopa-related motor complications (LDRMCs), the authors investigated, in an observational study, circadian rhythms of central temperature, motor activity, plasma cortisol, and melatonin in three groups: de novo untreated patients (group I), patients treated with levodopa + dopamine agonist and without LDRMCs (group II), and patients treated with levodopa + dopamine agonist and with LDRMCs (group III). There were no differences among the three groups for the rhythm of temperature, motor activity, or plasma cortisol. There was a significant (p < 0.05) phase advance in plasma melatonin secretion in patients receiving a dopaminergic treatment compared with untreated patients. The daytime area under the curve (AUC) was increased significantly in group III, and the nighttime AUC-to-daytime AUC ratio of melatonin secretion decreased significantly in group III, suggesting that the nychthemeral pattern of melatonin secretion was changed in patients with LDRMCs. Comparison of the three groups suggests a slight but insignificant phase advance and amplitude decrease of circadian melatonin secretion related to both evolution and treatment of Parkinson's disease. Despite the lack of a global desynchronization in other circadian biologic rhythms, the circadian secretion pattern of melatonin is modified in patients with LDRMCs.

Aged↗
PubMedDate not supplied

[Fratricide occurring during a nocturnal episode of somnambulism: a case report].

Occasionally, some people developed violent acts during their sleeping. Fortunately, these acts remain virtual and do not have serious life consequences. However, the execution of the dramatical act may happen in setting automatic activities. The manifestations of these acts are exceptional but very often misappreciated. Among them, we have been confronted to a case of "fratricide expertise" in the north of France. The person concerned is a teenager of 17, accused of the murder of his young brother, by several stabs, in the night. This homicide could be the consequence of multitude of factors. Though he hasn't shown clinical somnambulism, the results of electroencephalogram tracing were symptoms of predisposing factors. We can also imagine the facilitating effect of other factors, ephedrine, more particularly. The rapport with the relevant documents follows an expert's report and can be added to the cases published in the literature in which it was shown that the automatic activity may be at the origin of the medico-legal act of somnambulistic patients. Finally, we have been able to deduce two classes of factors, which may be responsible for violent act execution.

Adolescent↗
PubMedDate not supplied

[Femoral neuropathy with deafferentation pain. Complications of a hematoma during anticoagulant treatment].

A case of femoral palsy associated with chronic pain sensible to Carbamazepine, secondary to iliacus haematoma during anticoagulant therapy is reported. Late femoral nerve decompression followed by transcutaneous neurostimulation permit the normalization of the sensory nerve conduction and a complete clinical recovery. The localizations of hemorrhage and nervous compression are discussed. The necessity of a nerve decompression when features of nervous conduction persist is emphasized. Clinical symptomatology, Carbamazepine and transcutaneous neurostimulation efficacity, electrophysiological features are correlated with a central deafferentation state caused by an incomplete and heterogeneous lesion of the sensory nerve conduction pathways.

Carbamazepine↗