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Biomedical subjects

J D Gradon

Publications and source records attributed to J D Gradon.

44 records · Page 3Linked to original sources

Massive hepatic enlargement with fatty change associated with ketoconazole.

Several forms of hepatic toxicity have been described with the antifungal agent ketoconazole. We report a case of massive liver enlargement with fatty infiltration presenting as gastric compression. This occurred in a young woman with AIDS taking ketoconazole as maintenance therapy for cryptococcal meningitis. This is the first reported case of ketoconazole causing fatty change in the liver.

Adult↗

Severe hypomagnesemia associated with pentamidine therapy.

A case of severe hypomagnesemia in a patient with AIDS that manifested as changes in mental status is presented. The hypomagnesemia was due to renal wasting of magnesium, most probably caused by pentamidine-induced renal tubular injury. This entity has been reported once before and should be considered in the differential diagnosis of altered mental status in patients with AIDS.

Acquired Immunodeficiency Syndrome↗