Biomedical subjects

J D Gass

Publications and source records attributed to J D Gass.

At least 163 records · Page 9Linked to original sources

PubMed1976

Sarcoidosis with optic nerve and retinal involvement.

A patient with the typical funduscopic changes of sarcoidosis died following an accident. The histopathological findings in one eye were correlated with the ophthalmoscopic observations made several days prior to death. Gross and histopathological examination revealed that the characteristic whitish-yellow focal retinal exudates, the perivascular exudates with an appearance like candle wax drippings, the preretinal and intravitreal nodules, and the localized tumefactions on the inner surface of the retina and optic nerve head noted ophthalmoscopically were a result of the nodular proliferation of epithelioid cells. These cells appeared to be derived primarily from blood vessels in the retina and optic nerve head. Although subpigment epithelial granulomas were found, there were no granulomas present within the choroid or elsewhere within the uvea.

Adult↗

PubMed1976

Subretinal tracks in ophthalmomyiasis.

Three cases of presumed infestation of the human globe by the maggot of a true fly (order of Diptera) are presented. In each case, migration of the maggot through the subretinal space produced widespread ophthalmoscopic and fluorescein angiographic changes that are believed to be pathognomonic of subretinal ophthalmomyiasis. Despite extensive changes in the retinal pigment epithelium, each of the three patients expressed few symptoms and manifested minimal visual deficit.

Adolescent↗

PubMed1976

Contraction of a perifoveal epiretinal membrane simulating a macular hole.

Four patients observed for a three- to four-year period had a hole in an epiretinal membrane overlying the macula that mimicked a macular hole. In two patients the clinical appearance remained essentially constant. In one, the epiretinal membrane contracted further, reducing the apparent macular hole to a slit and causing the typical appearance of a macular pucker. In the fourth patient, the epiretinal membrane peeled spontaneously causing the apparent hole to disappear. None of the patients had static perimetric findings that suggested a true macular hole. All of the patients had normal or nearly normal visual acuity when first seen. This was maintained except in the patient who suffered further membrane contraction. Fluorescein angiography demonstrated a slight fluorescence in the base of the hole in three of the four patients; however, it was not as pronounced as one sees in true macular holes. Lamellar macular holes characteristically show no fluorescence in the area of the hole.

Aged↗

PubMed1976

The late stage of serpiginous (geographic) choroiditis.

Serpiginous and geographic choroiditis, one and the same disease, is characterized by episodic involvement of the pigment epithelium and choroid. Each new lesion passes through an acute phase into an atrophic and scarring one. We observed 20 patients, some with long-term follow-up; some had eventual widespread involvement of both posterior poles. There was no basis for the disease, and treatment did not affect its course. In the patients with long-term disease there was widespread atrophy of the choroid and pigment epithelium and variable amounts of pigment clumping and subretinal fibrous tissue deposition. In nine patients discrete peripheral patches of atrophy were also found. In some eyes the atrophy at the posterior pole had become so confluent that the condition could have been mistaken superficially for a primary choroidal dystrophy. The uninvolved areas appeared to be normal. The electroretinogram and electrooculogram were only affected when extensive disease was present.

Adrenal Cortex Hormones↗

PubMed1976

Fundus flavimaculatus and Stargardt's disease.

Of 42 patients studied who had fundus flavimaculatus and Stargardt's disease, most had reduced visual acuity due to an atrophic macular lesion. Family histories were consistent with autosomal-recessive inheritance. In some young patients, the yellow-white flecks developed with time, while in some older patients the flecks faded, pari passau with increasing retinal pigment epithelial atrophy. Fluorescein angiography showed that most white flecks were largely or totally nonfluorescent. Even after the flecks had faded from view, the sites where they had been usually remained nonfluorescent. In patients with lesions confined to the posterior pole, the electroretinogram and electro-oculogram were usually normal; in patients with widespread lesions, one or both tests were usually abnormal. Affected members of any one family had a similar distribution of fundus lesions.

Adolescent↗

PubMed1976

Acquired arterial macroaneurysms of the retina.

Fifteen patients with acquired arterial macroaneurysms of the retina, and an additional woman patient with some 18 aneurysms of the temporal retinal arterial tree of one eye, are described. Acquired aneurysms occur in patients in their sixth decade and older, are usually unilateral, and occur on the major arterial branches posterior to the equator. Customarily only one or two aneurysms are present. Most patients have a history of poorly controlled systemic hypertension or a raised blood pressure at the time of discovery of the macroaneurysm. Focal embolic damage to arterial walls should be considered in the investigation of these patients. In patients with decreased vision from macular oedema and circinate retinopathy, photocoagulation of the macroaneurysm may hasten the improvement in visual acuity.

Aged↗

PubMed1975