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J D Farley

Publications and source records attributed to J D Farley.

16 recordsLinked to original sources
PubMed1996

Back-projection and sensitivity analysis of the HIV-AIDS epidemic in the Caribbean.

In this study we estimated past human immunodeficiency virus (HIV) incidence in 19 nations in the primarily English-speaking Caribbean and projected the course of the epidemic to the year 1999. We compared the results obtained from several different models of HIV incidence and different assumed incubation distributions. Linear and nonlinear optimization methods were used to fit several models (power, logistic, spline, and step) to adult (age 15 years or older) AIDS incidence data derived from our existing surveillance system. All four models tested gave good fits to the data, with estimates of cumulative HIV incidence in 1993 ranging from 16,504 to 21,732. An increase in the assumed median of the AIDS incubation distribution by one year increased the estimates of current cumulative adult HIV incidence by approximately 12%; these estimates varied by as much as 6% between models. An adjustment of the data for possible reporting delay increased the estimates by approximately 7% and for underreporting by 25%. Despite their sensitivity to underlying assumptions, back-projection estimates provide useful insights into the patterns of HIV and AIDS incidence. The models indicate that HIV and AIDS incidences in the English-speaking Caribbean have been rising steadily, with adult HIV prevalence in the general population still less than 1%.

Acquired Immunodeficiency Syndrome↗
PubMed1992

Ataxia-telangiectasia in a child with vaccine-associated paralytic poliomyelitis.

Vaccine-acquired poliomyelitis developed in a nonimmunized 10-month-old boy. At age 4 years, ataxia-telangiectasia was recognized. We conclude that the occurrence of vaccine-related poliomyelitis warrants a detailed assessment of immunity, and that, in patients with ataxia-telangiectasia, the use of live vaccines may be hazardous, even in those with apparently normal immunity.

Ataxia Telangiectasia↗
PubMed1988

Endemic institutional salmonellosis due to lactose-fermenting Salmonella newport in Nova Scotia.

We report two outbreaks of salmonellosis due to lactose-fermenting Salmonella newport in a Halifax nursing home in August 1983 and July 1986 that we believe were related. The relative rarity of this serotype and other epidemiologic evidence suggest that the organism was endemic in the institution for at least 3 years. Persistent carriers as well as ill and convalescing patients presumably were responsible for propagation of the outbreak. We recommend adequate microbiologic follow-up of infected residents and implementation of surveillance and infection control measures for nursing homes and special care institutions.

Carrier State↗
PubMed1988

Primary hypothyroidism presenting as growth delay and pituitary enlargement.

We report the case of a young boy being considered for pituitary surgery because of pituitary enlargement found during assessment of growth delay. There was no goitre but he was hypothyroid clinically and biochemically. The finding of an elevated TSH suggested primary thyroid disease with thyrotroph hyperplasia. Treatment with L-thyroxine resulted in prompt resolution of his pituitary enlargement and improvement in his visual fields.

Child↗
PubMed1986

Pericarditis and ulcerative colitis.

We report an 18-year-old man with a pericardial effusion complicating idiopathic ulcerative colitis. Circulating immune complexes were absent. He responded to sulfasalazine and prednisone, with resolution of the pericarditis and improvement in the symptoms of his inflammatory bowel disease (IBD). We recommend looking for pericardial effusion or pericarditis in patients with IBD and chest symptoms, and for IBD in obscure cases of these cardiac disorders.

Adolescent↗
PubMed1976

Phylogenetic adaptations and the genetics of psychosis.

There is evidence that many social skills and responses which are of adaptive value are under a significant degree of genetic control. It is suggested that in states of hyper-arousal these skills are displayed in inappropriate and incomplete forms and that such behaviour constitutes psychosis. Genetic variation in these skills, under polygenic control, appears to be a determinant of the adaptiveness of the personality, with individuals at the extremes of the distribution tending to be maladjusted, chronically overaroused, and vulnerable to psychotic breakdown. Since the individual subjects's psychotic symptomatology will relflect the make-up of his genotype, the hypothesis is consistent with observed familial occurence of the different froms of functional psychosis. The hypothesis explains many of the characteristic manifestations of psychosis, including those in symptomatic psychosis, and also the genetic association with personality disorder. Evidence for the hypothesis and some predictions it generates are briefly reviewed.

Adult↗
PubMedDate not supplied

A swimming pool-associated outbreak of Cryptosporidiosis in British Columbia.

An outbreak of Cryptosporidiosis occurred over three months in a British Columbia community, peaking in December 1990. Results of the case-control study and illness surveys support the hypothesis that transmission occurred in a public children's pool at the local recreation centre. Analysis using lab-confirmed cases revealed a matched odds ratio of 4.5 [95% CI 0.97, 20.83], and using clinical cases an unmatched odds ratio of 12.8 [95% CI 3.68, 46.77], associated with swimming in the children's pool within two weeks prior to onset of illness. Other risk factors were not significant. Attack rates in various groups of children's pool users ranged from 8% to 78%. The children's pool was closed for steam cleaning and disinfection. Unusually frequent defecations including liquid stools had occurred before and during the outbreak. Improvements were instituted for removal of feces and superchlorination of pool water.

Adolescent↗